4-Methyl-1-oxaspiro[5.5]undecene (CAS 68228-06-08) — Woody Base Note Fragrance Ingredient
4-Methyl-1-oxaspiro[5.5]undecene
CAS 68228-06-08
What Is 4-Methyl-1-oxaspiro[5.5]undecene?
4-Methyl-1-oxaspiro[5.5]undecene is a synthetic fragrance ingredient used to add woody, ambery nuances to perfumes. You’ll find it in modern amber and woody fragrances where it contributes depth and warmth. This molecule matters because it helps create sophisticated, long-lasting fragrance bases without relying solely on natural materials, making scents more consistent and sustainable.
Safety Profile
GENERALLY SAFEWhat Does 4-Methyl-1-oxaspiro[5.5]undecene Smell Like?
A complex woody-amber note with intriguing duality. Opens with a crisp, almost ozonic top that quickly unfolds into a warm, slightly nutty heart reminiscent of toasted cedar. The dry-down reveals a sophisticated ambery base with whisper-like hints of vanilla and leather. Unlike traditional amber materials, it carries an airy, modern quality – like sunlight filtering through aged wooden beams in a minimalist loft.
In Famous Fragrances
Fragrance associations may not reflect actual formulations.
Used as a modern amber enhancer, adding lift to the traditional amber accord while maintaining depth.
Provides a contemporary woody facet to the flinty mineral accord, bridging citrus top to vetiver base.
Chemistry, Properties & Perfumer Guide
The Chemistry
A synthetic oxaspiro compound belonging to the cyclic ether class. The spiro structure (two rings sharing one carbon atom) creates unique conformational rigidity that influences its odor properties. Typically synthesized through acid-catalyzed cyclization of appropriate diol precursors. The methyl group at position 4 introduces subtle steric effects that modify its volatility and scent profile compared to unsubstituted analogs.
Physical & Chemical Properties
| Appearance | Colorless to pale yellow liquid |
|---|---|
| Odor Threshold | 0.003 ppm in air (estimated) |
Perfumer Guide
| Application | Typical % | Range | Notes |
|---|---|---|---|
| Fine Fragrance | 1-3% | Up to 5% | Base note modifier |
| Home Fragrance | 0.5-2% | Up to 3% | Amber accord component |
Classic Accords
Tip: Use with ionones to create a seamless transition between floral heart and woody base notes.
Alternatives & Comparisons
More marine/dry ambery character, better for fresh applications but lacks the woody depth.
Safety, Regulatory & Sustainability
⚠ Regulatory Disclaimer
General reference only. Consult current IFRA Standards Library before formulating.
IFRA Status
Not currently restricted under IFRA standards.
RIFM Assessment
Under evaluation by RIFM as of 2023.
Sustainability
As a synthetic material, production can be optimized for minimal environmental impact through green chemistry principles. Doesn’t rely on natural resource extraction, though energy inputs for synthesis should be considered. Biodegradability studies pending.
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References
- Frater et al. (1998). Synthesis and Olfactory Properties of Spirocyclic Ethers. Helvetica Chimica Acta.
Data: PubChem (NIH), PubMed, RIFM, IFRA. Last reviewed: Apr 2026.
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