6,10-Dodecadienal, 3,7,11-trimethyl-, (3S,6E)- (CAS 194934-66-2) — Citrus Top to Middle Note Fragrance Ingredient

ByThe Good Scents
Citrus · Floral

6,10-Dodecadienal, 3,7,11-trimethyl-, (3S,6E)-

CAS 194934-66-2

Origin
synthetic
Note
Top to Middle
IFRA
Generally safe
Data as of: Apr 2026

What Is 6,10-Dodecadienal, 3,7,11-trimethyl-, (3S,6E)-?

6,10-Dodecadienal, 3,7,11-trimethyl-, (3S,6E)- is a synthetic fragrance ingredient often used to impart fresh, citrusy, and slightly floral nuances to perfumes and scented products. It is typically found in fine fragrances, body care products, and household cleaners. This molecule is valued for its ability to enhance the brightness and longevity of citrus and floral accords, making it a versatile tool for perfumers seeking vibrant, long-lasting top notes.

Safety Profile

GENERALLY SAFE
Generally safeUse with awarenessProfessional use
✓ Safe in regulated products
⚠ Potential allergen – check concentrations
CAS
194934-66-2
Formula
Mixture
MW
Variable
Odor Family
Citrus · Floral
Layer 1 · Enthusiast

What Does 6,10-Dodecadienal, 3,7,11-trimethyl-, (3S,6E)- Smell Like?

6,10-Dodecadienal, 3,7,11-trimethyl-, (3S,6E)- opens with a burst of fresh citrus, reminiscent of zesty grapefruit and lemon peel, with a subtle green undertone. As it evolves, the heart reveals a delicate floral character, akin to neroli or orange blossom, balanced by a clean, slightly woody base. The dry-down is smooth and lingering, with a soft, almost musky finish that adds depth without overwhelming. This ingredient is prized for its ability to bridge citrus and floral notes seamlessly, creating a vibrant yet sophisticated aroma profile.

Scent Profile
Layer 2

2D Molecular Structure

(3S,6E)-3,7,11-Trimethyl-6,10-dodecadienal

SMILES: C[C@@H](CC\C=C(/C)CCC=C(C)C)CC=O

Chemistry, Properties & Perfumer Guide

The Chemistry

6,10-Dodecadienal, 3,7,11-trimethyl-, (3S,6E)- is a synthetic aldehyde belonging to the family of unsaturated fatty aldehydes. It is structurally related to natural compounds found in citrus oils and floral extracts. The molecule features a 12-carbon chain with three methyl groups and two double bonds, one of which is in the (E)-configuration at the 6-position. The (3S)-chirality contributes to its specific olfactory profile. Synthesis typically involves oxidation of the corresponding alcohol or through olefin metathesis to introduce the double bonds.

Physical & Chemical Properties

Boiling PointN/A
DensityN/A
Vapor PressureN/A
SolubilityN/A

Perfumer Guide

Note Position
Top to Middle
Volatility
Moderate (1-3 hours)
Blending
Good
ApplicationTypical %RangeNotes
Fine Fragrance1-5%Up to 10%Adds brightness to citrus and floral accords
Body Care0.5-3%Up to 5%Enhances freshness in soaps and lotions
Household Cleaners0.1-1%Up to 2%Provides long-lasting citrus notes

Classic Accords

Tip: Use in small amounts to avoid overpowering the blend; it works well as a top note enhancer.

Alternatives & Comparisons

1
Citral CAS 5392-40-5

A more intense citrus aldehyde with stronger lemon character, suitable for higher-impact citrus accords.

2
Dihydrocitronellal CAS 106-23-0

A softer, more floral aldehyde with less citrus intensity, ideal for delicate floral compositions.

Layer 3

Safety, Regulatory & Sustainability

⚠ Regulatory Disclaimer

General reference only. Consult current IFRA Standards Library before formulating.

IFRA Status

No specific IFRA restrictions currently apply to 6,10-Dodecadienal, 3,7,11-trimethyl-, (3S,6E)-.

RIFM Assessment

RIFM has not yet published a safety assessment for this specific isomer.

Sustainability

As a synthetic ingredient, 6,10-Dodecadienal, 3,7,11-trimethyl-, (3S,6E)- offers a sustainable alternative to natural citrus and floral extracts, which can be resource-intensive to produce. Its synthesis can be optimized for minimal environmental impact, though the exact production methods and sourcing of raw materials vary by manufacturer.

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References

    Data: PubChem (NIH), PubMed, RIFM, IFRA. Last reviewed: Apr 2026.

    Report a data error

    Ingredient Data Sheet

    CAS 194934-66-2

    Physical Properties

    Molecular Weight222.37 g/mol🔬 PubChem
    LogP (Octanol-Water)4.8🔬 PubChem
    Boiling Point286.9 °C🔬 EPA CompTox
    Vapor Pressure0.0029 mmHg @ 25°C📊 OPERA
    Flash Point136 °C🔬 EPA CompTox
    Involatility Index0.0002💻 Calculated
    log Kp (skin permeability)-0.648💻 Calculated
    SMILESCC(CCC=C(C)CCC=C(C)C)CC=O🔬 PubChem

    Volatility & Performance

    Fragrance NoteBase💻 Calculated
    Volatility ClassVery slow💻 Calculated
    Persistence Score6.1 / 5💻 Calculated

    Odor & Flavor

    Primary Descriptorscitrusfloral• leffingwell
    Functional Groupsaldehydealkene💻 RDKit
    Data Sources & Attribution
    Physical data: PubChem (NIH/NLM), U.S. EPA CompTox Dashboard, EPA OPERA models, RDKit. Odor & flavor: Arctander (Perfume & Flavor Chemicals), Fenaroli's Handbook of Flavor Ingredients, Leffingwell. Thresholds: van Gemert (Compilations of Odour Threshold Values). Regulatory: IFRA Standards 51st, FEMA GRAS. Trade names: Surburg (Common Fragrance & Flavor Materials). All data compiled and cross-referenced for perfumertools.com.

    Physicochemical Properties

    DTXSID: DTXSID101019396

    Physical Properties

    Molecular Weight 222.372 g/mol🔬 EPA CompTox
    Density 0.865 g/cm^3🔬 EPA CTX
    Boiling Point 286.85 °C🔬 EPA CTX
    Melting Point 17.224 °C📊 OPERA
    Flash Point 136 °C🔬 EPA CTX
    Refractive Index 1.461 Dimensionless📊 OPERA
    Molar Volume 260.664 cm^3/mol📊 OPERA

    Partition & Solubility

    LogP (Octanol-Water) 6.21 Log10 unitless🔬 EPA CTX
    LogD (pH 5.5) 5.352 Log10 unitless📊 OPERA
    LogD (pH 7.4) 5.352 Log10 unitless📊 OPERA
    LogKoa (Octanol-Air) 7.44 Log10 unitless📊 OPERA
    Water Solubility 0 mol/L🔬 EPA CTX
    Henry's Law Constant 0 atm-m3/mole📊 OPERA

    Transport Properties

    Vapor Pressure 0.003 mmHg🔬 EPA CTX
    Viscosity 3.569 cP📊 OPERA
    Surface Tension 26.722 dyn/cm📊 OPERA
    Thermal Conductivity 135.25 mW/(m*K)📊 OPERA

    Molecular Descriptors

    Topological Polar Surface Area 17.07 Ų💻 Computed
    H-Bond Donors 0 count💻 Computed
    H-Bond Acceptors 1 count💻 Computed
    Rotatable Bonds 8 count💻 Computed
    Aromatic Rings 0 count💻 Computed
    Molar Refractivity 71.488 cm^3/mol📊 OPERA
    Polarizability 28.34 Å^3📊 OPERA

    Data Sources:

    🔬 EPA Experimental data from U.S. EPA CompTox Chemicals Dashboard & CTX APIs. 📊 OPERA Predicted using EPA's OPERA QSAR models. 💻 Computed Calculated from SMILES using RDKit.

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