alpha-Methyl-cyclohexanepropanol (CAS 10528-67-3) — Woody Middle to base Note Fragrance Ingredient
alpha-Methyl-cyclohexanepropanol
CAS 10528-67-3
What Is alpha-Methyl-cyclohexanepropanol?
Alpha-Methyl-cyclohexanepropanol is a synthetic fragrance ingredient used in perfumes and personal care products. It contributes a woody, musky character often found in modern floral and oriental fragrances. This molecule matters because it adds depth and longevity to scent compositions, helping bridge volatile top notes with deeper base notes in contemporary perfumery.
Safety Profile
GENERALLY SAFEWhat Does alpha-Methyl-cyclohexanepropanol Smell Like?
Alpha-Methyl-cyclohexanepropanol presents a complex olfactory profile that evolves beautifully on skin. Initially, there’s a crisp woody character reminiscent of freshly split cedar, quickly softening into a rounded muskiness akin to warm skin after sun exposure. The dry-down reveals subtle floral undertones that linger close to the skin, behaving like a whisper of sandalwood infused with violet petals. Its tenacity allows it to serve as an excellent fixative, subtly amplifying surrounding notes without overpowering them.
In Famous Fragrances
Fragrance associations may not reflect actual formulations.
Used as a woody-musky bridge between the prominent sandalwood accord and spicy cardamom notes, adding diffusion and skin-scent warmth.
Provides subtle woody depth beneath the amber-saffron accord, enhancing the fragrance’s radiant yet intimate character.
2D Molecular Structure
SMILES: CC(O)CCC1CCCCC1
Chemistry, Properties & Perfumer Guide
The Chemistry
Alpha-Methyl-cyclohexanepropanol belongs to the cyclohexanol family, characterized by its substituted cyclohexane ring structure. As a synthetic material, it’s typically produced through hydrogenation of corresponding aromatic precursors or via Grignard reactions. The methyl substitution at the alpha position creates steric hindrance that influences both its odor profile and evaporation rate. While not found in nature, its structural analogs occur in various woody and ambery materials.
Physical & Chemical Properties
| Appearance | Colorless to pale yellow liquid |
|---|---|
| Boiling Point | ~250 °C (estimated) |
| Density | ~0.95 g/cm³ (estimated) |
Perfumer Guide
| Application | Typical % | Range | Notes |
|---|---|---|---|
| Fine Fragrance | 1-3% | Up to 5% | Woody-musky modifier |
| Functional Fragrance | 0.5-1% | Up to 2% | Fabric conditioner base |
Classic Accords
Tip: Use to add diffusion and warmth to woody accords without excessive sweetness.
Alternatives & Comparisons
More pronounced woody character with less muskiness, suitable when cleaner wood notes are desired.
Safety, Regulatory & Sustainability
⚠ Regulatory Disclaimer
General reference only. Consult current IFRA Standards Library before formulating.
IFRA Status
Not currently restricted by IFRA standards.
RIFM Assessment
Under evaluation by RIFM, preliminary data suggests low sensitization potential.
Sustainability
As a synthetic material, alpha-Methyl-cyclohexanepropanol offers consistent quality without natural sourcing constraints. Production typically uses petrochemical precursors, though green chemistry approaches are being explored. Its efficiency in formulations reduces overall material requirements compared to some natural alternatives.
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References
- Bauer, K. et al. (2001). Common Fragrance and Flavor Materials. Wiley-VCH.
Data: PubChem (NIH), PubMed, RIFM, IFRA. Last reviewed: Apr 2026.
Report a data errorIngredient Data Sheet
CAS 10528-67-3Physical Properties
| Molecular Weight | 156.26 g/mol🔬 PubChem |
| LogP (Octanol-Water) | 3.4🔬 PubChem |
| Boiling Point | 233.5 °C🔬 EPA CompTox |
| Vapor Pressure | 0.5475 mmHg @ 25°C📊 OPERA |
| Flash Point | 98 °C🔬 EPA CompTox |
| Involatility Index | 0.0472💻 Calculated |
| log Kp (skin permeability) | -1.239💻 Calculated |
| SMILES | CC(CCC1CCCCC1)O🔬 PubChem |
Volatility & Performance
| Fragrance Note | Heart💻 Calculated |
| Volatility Class | Slow💻 Calculated |
| Persistence Score | 0.5 / 5💻 Calculated |
Odor & Flavor
| Primary Descriptors | muskywoody• leffingwell |
| Functional Groups | alcohol💻 RDKit |
Physical data: PubChem (NIH/NLM), U.S. EPA CompTox Dashboard, EPA OPERA models, RDKit. Odor & flavor: Arctander (Perfume & Flavor Chemicals), Fenaroli's Handbook of Flavor Ingredients, Leffingwell. Thresholds: van Gemert (Compilations of Odour Threshold Values). Regulatory: IFRA Standards 51st, FEMA GRAS. Trade names: Surburg (Common Fragrance & Flavor Materials). All data compiled and cross-referenced for perfumertools.com.
Physicochemical Properties
DTXSID: DTXSID30884491
Physical Properties
| Molecular Weight | 156.269 g/mol🔬 EPA CompTox |
| Density | 0.903 g/cm^3🔬 EPA CTX |
| Boiling Point | 233.5 °C🔬 EPA CTX |
| Melting Point | 12.159 °C📊 OPERA |
| Flash Point | 98 °C🔬 EPA CTX |
| Refractive Index | 1.458 Dimensionless📊 OPERA |
| Molar Volume | 174.922 cm^3/mol📊 OPERA |
Partition & Solubility
| LogP (Octanol-Water) | 3.3 Log10 unitless🔬 EPA CTX |
| LogD (pH 5.5) | 3.004 Log10 unitless📊 OPERA |
| LogD (pH 7.4) | 3.004 Log10 unitless📊 OPERA |
| LogKoa (Octanol-Air) | 7.57 Log10 unitless📊 OPERA |
| Water Solubility | 0.002 mol/L🔬 EPA CTX |
| Henry's Law Constant | 0 atm-m3/mole📊 OPERA |
Transport Properties
| Vapor Pressure | 0.63 mmHg🔬 EPA CTX |
| Viscosity | 9.787 cP📊 OPERA |
| Surface Tension | 32.147 dyn/cm📊 OPERA |
| Thermal Conductivity | 142.488 mW/(m*K)📊 OPERA |
Molecular Descriptors
| Topological Polar Surface Area | 20.23 Ų💻 Computed |
| H-Bond Donors | 1 count💻 Computed |
| H-Bond Acceptors | 1 count💻 Computed |
| Rotatable Bonds | 3 count💻 Computed |
| Aromatic Rings | 0 count💻 Computed |
| Molar Refractivity | 47.756 cm^3/mol📊 OPERA |
| Polarizability | 18.932 Å^3📊 OPERA |
Data Sources:
🔬 EPA Experimental data from U.S. EPA CompTox Chemicals Dashboard & CTX APIs. 📊 OPERA Predicted using EPA's OPERA QSAR models. 💻 Computed Calculated from SMILES using RDKit.
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