Vanillin propylene glycol acetal (CAS 68527-74-2) — Sweet Middle Note Fragrance Ingredient
Vanillin propylene glycol acetal
CAS 68527-74-2
What Is Vanillin propylene glycol acetal?
Vanillin propylene glycol acetal is a synthetic fragrance ingredient that subtly enhances vanilla-like aromas in perfumes, candles, and baked goods. It’s often found in gourmand and oriental fragrance compositions. This molecule matters because it provides a more stable vanilla character than natural vanillin, with less volatility and better resistance to oxidation in formulations.
Safety Profile
GENERALLY SAFEWhat Does Vanillin propylene glycol acetal Smell Like?
A warm, creamy vanilla core wrapped in soft balsamic undertones, with none of vanillin’s sharp edges. The opening is surprisingly diffusive – like vanilla sugar dusting rising from a freshly baked pastry. As it settles, reveals a plush, almost lactonic quality reminiscent of vanilla custard. The dry-down lingers as a skin-like sweetness, blending seamlessly with amber and musk bases without overpowering.
In Famous Fragrances
Fragrance associations may not reflect actual formulations.
Used as a vanilla modifier that adds creaminess without the phenolic sharpness of natural vanillin. Provides the ‘baked’ quality that makes this fragrance smell like vanilla extract aging in oak barrels.
Employed here for its diffusive top note qualities, creating the illusion of vanilla beans freshly split open. The acetal bridges the citrus opening to the woody base.
Forms the core ‘white vanilla’ accord, contributing a powdered sugar effect that makes this fragrance smell like vanilla-infused confectioner’s sugar.
Used judiciously to soften the frankincense notes, creating a ‘vanilla incense’ effect where the sweetness never becomes cloying.
Provides the ‘steamed milk’ facet of this tea-infused vanilla, blending with the bergamot to create a London Fog latte effect.
Chemistry, Properties & Perfumer Guide
The Chemistry
Vanillin propylene glycol acetal belongs to the acetals class, formed by reacting vanillin with propylene glycol. This protects the aldehyde group, increasing stability while modifying olfactive properties. The molecule retains vanillin’s aromatic methoxy and hydroxy substitutions but gains enhanced hydrophobicity from the acetal formation. Industrial synthesis typically involves acid-catalyzed condensation under controlled conditions to prevent polymerization.
Physical & Chemical Properties
| Appearance | Colorless to pale yellow liquid |
|---|---|
| Solubility | Soluble in alcohol, insoluble in water |
Perfumer Guide
| Application | Typical % | Range | Notes |
|---|---|---|---|
| Fine Fragrance | 0.5-2% | Up to 5% | Vanilla modifier |
| Candles | 1-3% | Up to 8% | Heat-stable vanilla |
| Bakery Flavors | 10-50 ppm | Up to 100 ppm | Creamy vanilla note |
Classic Accords
Tip: Use as a bridge between citrus top notes and vanilla bases to prevent harsh transitions.
Alternatives & Comparisons
When stronger vanilla impact is needed, though lacks the creamy subtlety of the acetal.
Safety, Regulatory & Sustainability
⚠ Regulatory Disclaimer
General reference only. Consult current IFRA Standards Library before formulating.
IFRA Status
No IFRA restrictions. Not classified as an allergen.
RIFM Assessment
Considered safe for current fragrance use levels based on RIFM evaluation.
Sustainability
Synthetic production avoids vanilla crop sustainability issues. Manufacturing involves controlled chemical processes with high atom economy. Being more potent than natural vanillin, it reduces material requirements per unit of fragrance.
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References
- Bauer et al. (2001). Common Fragrance and Flavor Materials. Wiley-VCH.
- Sell, C. (2006). The Chemistry of Fragrances. RSC Publishing.
Data: PubChem (NIH), PubMed, RIFM, IFRA. Last reviewed: Apr 2026.
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