Benzene, 1,2,3-trimethoxy- (CAS 634-36-6) — Woody Middle Note Fragrance Ingredient

ByThe Good Scents
Woody · Spicy

Benzene, 1,2,3-trimethoxy-

CAS 634-36-6

Origin
synthetic
Note
Middle
IFRA
Use with awareness
Data as of: Apr 2026

What Is Benzene, 1,2,3-trimethoxy-?

Benzene, 1,2,3-trimethoxy- is a synthetic aromatic compound used in fragrance formulations. It imparts a warm, spicy, and slightly woody scent. This ingredient is typically found in niche perfumes and industrial fragrances. Its unique profile makes it valuable for creating complex accords, especially in oriental and woody compositions.

Safety Profile

USE WITH AWARENESS
Generally safeUse with awarenessProfessional use
⚠ Potential skin irritant
⚠ Use in diluted form
CAS
634-36-6
Formula
Mixture
MW
Variable
Odor Family
Woody · Spicy
Layer 1 · Enthusiast

What Does Benzene, 1,2,3-trimethoxy- Smell Like?

Benzene, 1,2,3-trimethoxy- offers a warm, spicy aroma with subtle woody undertones. The scent evolves from a sharp, slightly medicinal top note to a smoother, more rounded heart. The dry-down reveals a lingering, slightly sweet woody character, making it versatile in perfumery.

Scent Profile
Layer 2

Chemistry, Properties & Perfumer Guide

The Chemistry

Benzene, 1,2,3-trimethoxy- is a synthetic aromatic compound belonging to the benzene derivatives class. It is typically synthesized through the methylation of catechol derivatives. The compound’s structure features three methoxy groups attached to a benzene ring, contributing to its unique olfactory profile.

Physical & Chemical Properties

Boiling PointN/A
DensityN/A

Perfumer Guide

Note Position
Middle
Volatility
Medium (2-4 hours)
Blending
Good
ApplicationTypical %RangeNotes
Fine Fragrance1-3%Up to 5%Adds warmth and complexity
Industrial Fragrance0.5-2%Up to 3%Used for spicy woody notes

Classic Accords

Tip: Use sparingly to avoid overpowering other notes.

Alternatives & Comparisons

1
Eugenol CAS 97-53-0

A natural alternative with similar spicy notes, but less woody.

2
Isoeugenol CAS 97-54-1

Offers a smoother, less harsh spicy note compared to benzene derivatives.

Layer 3

Safety, Regulatory & Sustainability

⚠ Regulatory Disclaimer

General reference only. Consult current IFRA Standards Library before formulating.

IFRA Status

No specific IFRA restrictions noted.

GHS Classification

H315 Skin irritation H319 Eye irritation

RIFM Assessment

No RIFM safety assessment found.

Sustainability

As a synthetic compound, benzene, 1,2,3-trimethoxy- is produced through chemical synthesis, which may involve petrochemical feedstocks. Environmental impact depends on manufacturing processes and waste management.

Explore Benzene, 1,2,3-trimethoxy-

Browse essential oils and aroma compounds.

Browse on iHerb →

Affiliate disclosure: we may earn a small commission at no extra cost to you.

References

  1. PubChem Compound Summary for Benzene, 1,2,3-trimethoxy- PubChem

Data: PubChem (NIH), PubMed, RIFM, IFRA. Last reviewed: Apr 2026.

Report a data error

Similar Posts