Tetrahydro-4-methyl-2-(2-methylpropen-1-yl)pyran (CAS 16409-43-1) — Woody Middle Note Fragrance Ingredient

ByThe Good Scents
Woody · Floral

Tetrahydro-4-methyl-2-(2-methylpropen-1-yl)pyran

CAS 16409-43-1

Origin
synthetic
Note
Middle
IFRA
Generally safe
Data as of: Apr 2026

What Is Tetrahydro-4-methyl-2-(2-methylpropen-1-yl)pyran?

Tetrahydro-4-methyl-2-(2-methylpropen-1-yl)pyran is a synthetic fragrance ingredient used to add woody, floral nuances to perfumes. Consumers encounter it in air fresheners and fabric conditioners. Its balanced profile makes it versatile for creating modern scent accords.

Safety Profile

GENERALLY SAFE
Generally safeUse with awarenessProfessional use
✓ Safe in regulated concentrations
⚠ Check IFRA guidelines for specific applications
CAS
16409-43-1
Formula
Mixture
MW
Variable
Odor Family
Woody · Floral
Layer 1 · Enthusiast

What Does Tetrahydro-4-methyl-2-(2-methylpropen-1-yl)pyran Smell Like?

This molecule offers a clean woody-floral character with subtle green undertones. Imagine the crispness of freshly cut stems blending with the warmth of sun-baked woods. The dry-down reveals a soft, slightly sweet persistence.

Scent Profile
Layer 2

2D Molecular Structure

4-Methyl-2-(2-methylprop-1-en-1-yl)tetrahydro-2H-pyran

SMILES: CC1CCOC(C1)C=C(C)C

Chemistry, Properties & Perfumer Guide

The Chemistry

Tetrahydro-4-methyl-2-(2-methylpropen-1-yl)pyran belongs to the pyran class of heterocyclic compounds. It’s synthesized through Diels-Alder reactions or hydrogenation of corresponding pyrans. The methylpropenyl side chain contributes to its volatility and odor characteristics.

Physical & Chemical Properties

Boiling PointNot available
DensityNot available

Perfumer Guide

Note Position
Middle
Volatility
Medium (2-4 hours)
Blending
Good
ApplicationTypical %RangeNotes
Fine Fragrance1-5%Up to 10%Used as floral-woody modifier
Functional Products0.5-2%Up to 5%Provides clean background note

Classic Accords

Tip: Use with citrus notes to brighten woody compositions.

Alternatives & Comparisons

1
Dihydromyrcenol CAS 18479-58-8

Offers similar fresh woody character with higher volatility.

2
Linalool CAS 78-70-6

Natural alternative with floral aspects but different tenacity.

Layer 3

Safety, Regulatory & Sustainability

⚠ Regulatory Disclaimer

General reference only. Consult current IFRA Standards Library before formulating.

IFRA Status

No specific restrictions under current IFRA standards.

RIFM Assessment

No RIFM safety assessment currently available.

Sustainability

As a synthetic material, production can be optimized for minimal environmental impact. Manufacturers should follow green chemistry principles in synthesis.

Explore Tetrahydro-4-methyl-2-(2-methylpropen-1-yl)pyran

Browse essential oils and aroma compounds.

Browse on iHerb →

Affiliate disclosure: we may earn a small commission at no extra cost to you.

References

    Data: PubChem (NIH), PubMed, RIFM, IFRA. Last reviewed: Apr 2026.

    Report a data error

    Ingredient Data Sheet

    CAS 16409-43-1

    Physical Properties

    Molecular Weight154.25 g/mol🔬 PubChem
    LogP (Octanol-Water)2.9🔬 PubChem
    Boiling Point86 °C🔬 EPA CompTox
    Vapor Pressure0.3975 mmHg @ 25°C📊 OPERA
    Flash Point64 °C🔬 EPA CompTox
    Involatility Index0.0345💻 Calculated
    log Kp (skin permeability)-1.582💻 Calculated
    SMILESCC1CCOC(C1)C=C(C)C🔬 PubChem

    Volatility & Performance

    Fragrance NoteTop💻 Calculated
    Volatility ClassSlow💻 Calculated
    Persistence Score0.7 / 5💻 Calculated

    Odor & Flavor

    Primary Descriptorsearthygreenrose• leffingwell
    Functional Groupsetheralkene💻 RDKit
    “Penetrating and very diffusive, gassy-green or "hard" green, floral odor of poor tenacity. The resemblance to Geranium appears only upon dilution of the Rose oxide, and best in a composition. The diluted material has also a Rose-like character. Certain materials have a less gassy, more "bread-like" topnote, which is warmer and more pleasant than the "gassy" type of odor.”📖 Arctander
    Tetrahydro-4-methyl-2-(2-methylpropen-1-yl)pyran has a powerful distinctive geranium topnote.📖 Fenaroli

    Regulatory Status

    IOFI ClassificationNature Identical📖 Fenaroli
    Data Sources & Attribution
    Physical data: PubChem (NIH/NLM), U.S. EPA CompTox Dashboard, EPA OPERA models, RDKit. Odor & flavor: Arctander (Perfume & Flavor Chemicals), Fenaroli's Handbook of Flavor Ingredients, Leffingwell. Thresholds: van Gemert (Compilations of Odour Threshold Values). Regulatory: IFRA Standards 51st, FEMA GRAS. Trade names: Surburg (Common Fragrance & Flavor Materials). All data compiled and cross-referenced for perfumertools.com.

    Physicochemical Properties

    DTXSID: DTXSID1051771

    Physical Properties

    Molecular Weight 154.253 g/mol🔬 EPA CompTox
    Density 0.883 g/cm^3🔬 EPA CTX
    Boiling Point 230 °C🔬 EPA CTX
    Melting Point -28.712 °C📊 OPERA
    Flash Point 64.5 °C🔬 EPA CTX
    Refractive Index 1.496 Dimensionless📊 OPERA
    Molar Volume 169.683 cm^3/mol📊 OPERA

    Partition & Solubility

    LogP (Octanol-Water) 3.45 Log10 unitless🔬 EPA CTX
    LogD (pH 5.5) 3.768 Log10 unitless📊 OPERA
    LogD (pH 7.4) 3.768 Log10 unitless📊 OPERA
    LogKoa (Octanol-Air) 4.74 Log10 unitless📊 OPERA
    Water Solubility 0.005 mol/L🔬 EPA CTX
    Henry's Law Constant 0 atm-m3/mole📊 OPERA

    Transport Properties

    Vapor Pressure 0.488 mmHg🔬 EPA CTX
    Viscosity 1.529 cP📊 OPERA
    Surface Tension 27.034 dyn/cm📊 OPERA
    Thermal Conductivity 119.265 mW/(m*K)📊 OPERA

    Molecular Descriptors

    Topological Polar Surface Area 9.23 Ų💻 Computed
    H-Bond Donors 0 count💻 Computed
    H-Bond Acceptors 1 count💻 Computed
    Rotatable Bonds 1 count💻 Computed
    Aromatic Rings 0 count💻 Computed
    Molar Refractivity 49.593 cm^3/mol📊 OPERA
    Polarizability 19.66 Å^3📊 OPERA

    Data Sources:

    🔬 EPA Experimental data from U.S. EPA CompTox Chemicals Dashboard & CTX APIs. 📊 OPERA Predicted using EPA's OPERA QSAR models. 💻 Computed Calculated from SMILES using RDKit.

    Similar Posts