Cyclohexadecenone (CAS 88642-03-09) — Musky Base Note Fragrance Ingredient
Cyclohexadecenone
CAS 88642-03-09
What Is Cyclohexadecenone?
Cyclohexadecenone is a synthetic musk compound used in modern perfumery. It’s found in laundry detergents, fabric softeners, and some prestige fragrances. This ingredient matters because it provides long-lasting muskiness without animal-derived materials, making it vegan-friendly while delivering the warmth we associate with clean laundry and skin.
Safety Profile
USE WITH AWARENESSWhat Does Cyclohexadecenone Smell Like?
Cyclohexadecenone unfolds as a velvety musk with surprising complexity. Initially presenting a clean, soapy character reminiscent of freshly laundered linen, it gradually reveals warmer facets – imagine sun-warmed skin after a shower. The dry-down is particularly noteworthy, leaving a subtle trail that blends seamlessly with skin chemistry, creating an intimate ‘your skin but better’ effect. Unlike some musks that dominate, this molecule plays well with florals and woods, adding depth without overpowering.
In Famous Fragrances
Fragrance associations may not reflect actual formulations.
Used as the musk backbone that makes this celebrity scent so wearable, providing clean warmth that lasts through the dry-down.
The synthetic musk mimics freshly dried laundry, creating the signature ‘just washed’ effect that defines this line.
Chemistry, Properties & Perfumer Guide
The Chemistry
Cyclohexadecenone belongs to the macrocyclic musk family, synthetic alternatives to natural muscone. These large-ring ketones mimic animal musks without ethical concerns. The synthesis typically involves ring-closing metathesis of long-chain dienes, followed by selective hydrogenation. Unlike nitro musks, macrocyclics like cyclohexadecenone are more environmentally persistent but show lower bioaccumulation potential.
Physical & Chemical Properties
| Appearance | Colorless to pale yellow liquid |
|---|---|
| Molecular Weight | 236.39 g/mol |
Perfumer Guide
| Application | Typical % | Range | Notes |
|---|---|---|---|
| Fine Fragrance | 1-3% | Up to 5% | Musk foundation |
| Laundry Care | 0.1-0.5% | Up to 1% | Clean fabric impression |
Classic Accords
Tip: Use with citrus top notes to create dynamic contrast between freshness and warmth.
Alternatives & Comparisons
More affordable macrocyclic musk with similar properties but slightly sweeter character.
Safety, Regulatory & Sustainability
⚠ Regulatory Disclaimer
General reference only. Consult current IFRA Standards Library before formulating.
IFRA Status
No restrictions under IFRA standards. Approved for all fragrance categories.
RIFM Assessment
RIFM assessment confirms safe use at current industry levels with adequate margin of safety.
Sustainability
As a synthetic musk, cyclohexadecenone avoids the ecological impact of animal-derived musks. However, like all macrocyclic musks, it shows moderate persistence in waterways. Manufacturers are developing biodegradable variants to address this. The synthetic production has consistent quality control and doesn’t rely on harvesting from nature.
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References
- IFRA Standards Library. 2023. Macrocyclic Musks. IFRA Standards
Data: PubChem (NIH), PubMed, RIFM, IFRA. Last reviewed: Apr 2026.
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