2,4-Dimethylpyridine (CAS 108-47-4) — Woody Top Note Fragrance Ingredient
2,4-Dimethylpyridine
CAS 108-47-4
What Is 2,4-Dimethylpyridine?
2,4-Dimethylpyridine is a synthetic chemical used in fragrance formulations. It is encountered in niche perfumery and industrial applications. This ingredient matters because it adds unique aromatic qualities and complexity to fragrances, though it is not commonly found in consumer products.
Safety Profile
USE WITH AWARENESSWhat Does 2,4-Dimethylpyridine Smell Like?
2,4-Dimethylpyridine has a sharp, pungent odor with a distinct pyridine character. It evolves from a harsh, chemical top note to a more subdued, slightly sweet and woody dry-down. The scent is often described as reminiscent of burnt rubber or tobacco, with a lingering aromatic quality.
In Famous Fragrances
Fragrance associations may not reflect actual formulations.
Used to add a sharp, aromatic edge to the fragrance, enhancing its synthetic and futuristic character.
2D Molecular Structure
SMILES: CC1=CC=NC(C)=C1
Chemistry, Properties & Perfumer Guide
The Chemistry
2,4-Dimethylpyridine is a heterocyclic aromatic compound belonging to the pyridine family. It is synthesized through alkylation of pyridine or via Chichibabin reaction. The molecule features two methyl groups at the 2 and 4 positions, influencing its electronic and steric properties.
Physical & Chemical Properties
| Boiling Point | N/A |
|---|---|
| Density | N/A |
Perfumer Guide
| Application | Typical % | Range | Notes |
|---|---|---|---|
| Fine Fragrance | 0.1-0.5% | Up to 1% | Used sparingly for sharp aromatic effects |
Classic Accords
Tip: Use in trace amounts to avoid overpowering the fragrance.
Alternatives & Comparisons
A simpler pyridine derivative with a similar but less complex odor profile.
Safety, Regulatory & Sustainability
⚠ Regulatory Disclaimer
General reference only. Consult current IFRA Standards Library before formulating.
IFRA Status
Not currently restricted by IFRA.
GHS Classification
RIFM Assessment
No RIFM safety assessment available.
Sustainability
2,4-Dimethylpyridine is synthesized from petrochemical sources. Its environmental impact is moderate, with potential concerns during production and disposal. Sustainable alternatives are being explored.
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References
- PubChem: 2,4-Dimethylpyridine PubChem
Data: PubChem (NIH), PubMed, RIFM, IFRA. Last reviewed: Apr 2026.
Report a data errorIngredient Data Sheet
CAS 108-47-4Physical Properties
| Molecular Weight | 107.15 g/mol🔬 PubChem |
| LogP (Octanol-Water) | 1.6🔬 PubChem |
| Boiling Point | 159 °C🔬 EPA CompTox |
| Vapor Pressure | 3.17 mmHg @ 25°C📊 OPERA |
| Flash Point | 37 °C🔬 EPA CompTox |
| Involatility Index | 0.3301💻 Calculated |
| log Kp (skin permeability) | -2.218💻 Calculated |
| SMILES | CC1=CC(=NC=C1)C🔬 PubChem |
Volatility & Performance
| Fragrance Note | Top💻 Calculated |
| Volatility Class | Moderate💻 Calculated |
| Persistence Score | 0.5 / 5💻 Calculated |
Odor & Flavor
| Primary Descriptors | animalicfishygreenmintyphenolicsmoky• leffingwell |
| Functional Groups | aromatic💻 RDKit |
| “Powerful and diffusive minty-tarry odor of poor tenacity (when the material is pure, but technical grades leave a very tenacious naphthalenic dryout note).”📖 Arctander | |
Flavor Notes (Arctander)
| “It should be kept in mind that Piperidine and other related chemicals are used and permitted in perfumes and flavors, see monograph: Piperidine. It is most conceivable that this material will remain a very rarely used one in perfumes. It is not used in flavors, as far as the author is aware.”📖 Arctander |
Physical data: PubChem (NIH/NLM), U.S. EPA CompTox Dashboard, EPA OPERA models, RDKit. Odor & flavor: Arctander (Perfume & Flavor Chemicals), Fenaroli's Handbook of Flavor Ingredients, Leffingwell. Thresholds: van Gemert (Compilations of Odour Threshold Values). Regulatory: IFRA Standards 51st, FEMA GRAS. Trade names: Surburg (Common Fragrance & Flavor Materials). All data compiled and cross-referenced for perfumertools.com.
Physicochemical Properties
DTXSID: DTXSID2051556
Physical Properties
| Molecular Weight | 107.156 g/mol🔬 EPA CompTox |
| Density | 0.925 g/cm^3🔬 EPA CTX |
| Boiling Point | 158.75 °C🔬 EPA CTX |
| Melting Point | -61.818 °C🔬 EPA CTX |
| Flash Point | 42 °C🔬 EPA CTX |
| Refractive Index | 1.502 Dimensionless📊 OPERA |
| Molar Volume | 115.208 cm^3/mol📊 OPERA |
Partition & Solubility
| LogP (Octanol-Water) | 1.661 Log10 unitless📊 OPERA |
| LogD (pH 5.5) | 0.398 Log10 unitless📊 OPERA |
| LogD (pH 7.4) | 1.572 Log10 unitless📊 OPERA |
| LogKoa (Octanol-Air) | 3.73 Log10 unitless📊 OPERA |
| Water Solubility | 2.623 mol/L🔬 EPA CTX |
| Henry's Law Constant | 0 atm-m3/mole🔬 EPA CTX |
Transport Properties
| Vapor Pressure | 3.158 mmHg🔬 EPA CTX |
| Viscosity | 1.274 cP📊 OPERA |
| Surface Tension | 32.732 dyn/cm📊 OPERA |
| Thermal Conductivity | 134.052 mW/(m*K)📊 OPERA |
Molecular Descriptors
| Topological Polar Surface Area | 12.89 Ų💻 Computed |
| H-Bond Donors | 0 count💻 Computed |
| H-Bond Acceptors | 1 count💻 Computed |
| Rotatable Bonds | 0 count💻 Computed |
| Aromatic Rings | 1 count💻 Computed |
| Molar Refractivity | 33.994 cm^3/mol📊 OPERA |
| Polarizability | 13.476 Å^3📊 OPERA |
Data Sources:
🔬 EPA Experimental data from U.S. EPA CompTox Chemicals Dashboard & CTX APIs. 📊 OPERA Predicted using EPA's OPERA QSAR models. 💻 Computed Calculated from SMILES using RDKit.
