epsilon-Dodecalactone (CAS 16429-21-3) — Mid Note Fragrance Ingredient

ByThe Good Scents



gourmand

epsilon-Dodecalactone

CAS 16429-21-3

Note
mid
Volatility
low
MW
198.3
Data as of: Jun 2026

What Is epsilon-Dodecalactone?

epsilon-Dodecalactone (CAS 16429-21-3) is an aroma chemical used as a fragrance and flavour ingredient. Its odour is described as fatty, buttery and creamy, placing it within the gourmand family as a mid note with low volatility. With a molecular weight of 198.3 (formula C12H22O2), it is handled by perfumers as a building block for compositions where a fatty character is desired. The data below is compiled from public chemical and regulatory sources.

Safety Profile

GENERALLY SAFE

Generally safeUse with awarenessProfessional use
CAS
16429-21-3
Formula
C12H22O2
MW
198.3
InChIKey
FRTMRFCNTDDSOB-UHFFFAOYNA-N
epsilon-Dodecalactone 2D structure

epsilon-Dodecalactone
C12H22O2
Layer 1 · Enthusiast

What Does epsilon-Dodecalactone Smell Like?

The odour profile of epsilon-Dodecalactone is reported as fatty, buttery, creamy, milky, sweet, peach. The dominant facet is its fatty character, with the remaining notes adding nuance and complexity. As a mid note it contributes to the heart of a fragrance. Perceived intensity and exact character depend on concentration, the carrier and the surrounding accord.

Scent Profile

Profile derived from public odour-descriptor data; relative, not absolute.

Layer 2

Chemistry & Properties

The Chemistry

epsilon-Dodecalactone has the molecular formula C12H22O2 and a molecular weight of 198.3 g/mol. Its canonical SMILES representation is CCCCCCC1CCCCC(=O)O1. Its reported log P (XLogP) of 3.44 indicates a lipophilic, oil-soluble molecule, which informs how it partitions in a formula. Physical constants below are drawn from PubChem and EPA CompTox public datasets.

Physical & Chemical Properties

Molecular Weight 198.3 g/mol
Boiling Point 277.2 °C
Melting Point 13.11 °C
Flash Point 115.4 °C
Density 0.95 g/cm³
Vapor Pressure 0.001835 mmHg
Water Solubility 0.001 g/L
XLogP 3.44

Perfumer Guide

Note Position
Mid
Volatility
Low
Primary Odour
Fatty

Alternatives & Comparisons

Ingredients occupying a similar odour space — useful as substitutes or companions when epsilon-Dodecalactone is unavailable or restricted.

1
3-dodecyloxolan-2-one CAS 73263-36-2

Shares floral, sweet, buttery character — a candidate substitute or companion in the same odour space.

2
4-Methyl-2,3-Pentanedione CAS 7493-58-5

Shares pungent, buttery, sweet character — a candidate substitute or companion in the same odour space.

3
2-Undecenenitrile CAS 22629-48-7

Shares sweet, cucumber, fatty character — a candidate substitute or companion in the same odour space.

Layer 3

Safety & Regulatory

⚠ Regulatory Disclaimer

General reference only. IFRA, REACH and EU Cosmetics Regulation standards update periodically. Consult the current IFRA Standards Library before formulating. Not legal or regulatory advice.

IFRA Status

No IFRA restriction recorded in the data set. This is not a guarantee of unrestricted status — always confirm against the current IFRA Standards Library.

Odour detection threshold (air): 0.02 ppb — a literature-curated value indicating its potency in the vapour phase.

Formulating with epsilon-Dodecalactone?

Open epsilon-Dodecalactone in Fragrance Studio (Pro) for the calibrated vapour-pressure curve, the modelled odour-threshold estimate, and the substitute-matching engine across 2,900+ aromachemicals.

Open in Fragrance Studio →

Free · Web-based · No install required

References & Sources

  1. PubChem Compound Summary (NIH) — search by InChIKey
  2. EPA CompTox Chemicals Dashboard — physicochemical & fate data
  3. IFRA Standards Library (49th / 51st Amendment)
Sources: PubChem (NIH) · EPA CompTox · IFRA Standards Library · public GHS classification. Odour descriptors are original editorial summaries of public profiles, not reproduced from any single proprietary source.

Data: PubChem (NIH), EPA CompTox, IFRA. Last reviewed: Jun 2026.

Report a data error

Similar Posts