Ethanone, 1-[(1R,2S)-1,2,3,4,5,6,7,8-octahydro-1,2,8,8-tetramethyl-2-naphthalenyl]-, rel- (CAS 185429-83-8) — Musky Base Note Fragrance Ingredient
Ethanone, 1-[(1R,2S)-1,2,3,4,5,6,7,8-octahydro-1,2,8,8-tetramethyl-2-naphthalenyl]-, rel-
CAS 185429-83-8
What Is Ethanone, 1-[(1R,2S)-1,2,3,4,5,6,7,8-octahydro-1,2,8,8-tetramethyl-2-naphthalenyl]-, rel-?
This synthetic ingredient is a specialized musk compound used in modern perfumery. It creates subtle, long-lasting animalic nuances in premium fragrances. Found in niche perfumes, it provides sophisticated base notes that enhance depth and sensuality without using natural animal-derived musks.
Safety Profile
USE WITH AWARENESSWhat Does Ethanone, 1-[(1R,2S)-1,2,3,4,5,6,7,8-octahydro-1,2,8,8-tetramethyl-2-naphthalenyl]-, rel- Smell Like?
A warm, intimate musk with velvety textures reminiscent of sun-warmed skin. Opens with soft powdery nuances that transition into a creamy, slightly animalic heart. The dry-down reveals remarkable tenacity – like the lingering memory of a lover’s scent on fabric. Compared to traditional musks, it’s more refined than crude animalics but more complex than clean white musks.
In Famous Fragrances
Fragrance associations may not reflect actual formulations.
Used here to amplify the animalic signature while maintaining modern perfumery standards. Provides the ‘living skin’ effect that makes this fragrance legendary.
Modern reformulations use this to replace original animal musks while preserving the erotic, slightly sweaty base note complexity.
2D Molecular Structure
SMILES: C[C@@H]1C2=C(CCCC2(C)C)CC[C@]1(C)C(C)=O
Chemistry, Properties & Perfumer Guide
The Chemistry
A synthetic macrocyclic musk belonging to the tetralin family. Developed as an alternative to nitro musks and animal-derived muscone. The stereochemistry at positions 1 and 2 creates its unique odor profile. Typically synthesized through Diels-Alder reactions followed by selective hydrogenation and oxidation steps.
Physical & Chemical Properties
| Appearance | Colorless to pale yellow viscous liquid |
|---|---|
| Boiling Point | Estimated 300-320°C |
| Flash Point | >100°C |
| Vapor Pressure | <0.01 mmHg at 25°C |
Perfumer Guide
| Application | Typical % | Range | Notes |
|---|---|---|---|
| Fine Fragrance | 0.5-2% | Up to 3% | Provides sensual depth without overpowering |
| Fabric Conditioners | 0.1-0.5% | Up to 1% | Leaves subtle lingering scent on textiles |
| Luxury Soaps | 0.3-1% | Up to 2% | Stable in alkaline formulations |
Classic Accords
Tip: Pre-dilute to 10% in DEP or IPM before incorporating into bases to ensure even distribution.
Alternatives & Comparisons
When a cleaner, more laundry-musk effect is desired. Less animalic but similarly tenacious.
For more diffusive musk effects with radiant lift. The delta variant has superior odor strength.
Safety, Regulatory & Sustainability
⚠ Regulatory Disclaimer
General reference only. Consult current IFRA Standards Library before formulating.
IFRA Status
Not currently restricted under IFRA standards. Listed on Annex II of EU Cosmetics Regulation as permitted with proper documentation.
EU Allergen Declaration
Not listed as EU allergen. Does not require declaration under current regulations.
GHS Classification
RIFM Assessment
RIFM-reviewed with favorable safety profile at current industry usage levels.
Sustainability
Synthetic production avoids ethical concerns of animal-derived musks while allowing precise quality control. The multi-step synthesis has moderate environmental impact, offset by the material’s extreme potency requiring minimal quantities per formulation.
Explore Ethanone, 1-[(1R,2S)-1,2,3,4,5,6,7,8-octahydro-1,2,8,8-tetramethyl-2-naphthalenyl]-, rel-
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References
- IFRA Standards Library (2023). Restricted Materials List. IFRA
- Sell CS (2006). The Chemistry of Fragrances. RSC Publishing.
Data: PubChem (NIH), PubMed, RIFM, IFRA. Last reviewed: Apr 2026.
Report a data errorPhysicochemical Properties
DTXSID: DTXSID4051821
Physical Properties
| Molecular Weight | 234.383 g/mol🔬 EPA CompTox |
| Density | 0.944 g/cm^3📊 OPERA |
| Boiling Point | 296.05 °C📊 OPERA |
| Melting Point | 40.835 °C📊 OPERA |
| Flash Point | 135.487 °C📊 OPERA |
| Refractive Index | 1.493 Dimensionless📊 OPERA |
| Molar Volume | 246.33 cm^3/mol📊 OPERA |
Partition & Solubility
| LogP (Octanol-Water) | 4.836 Log10 unitless📊 OPERA |
| LogD (pH 5.5) | 4.836 Log10 unitless📊 OPERA |
| LogD (pH 7.4) | 4.836 Log10 unitless📊 OPERA |
| LogKoa (Octanol-Air) | 7.43 Log10 unitless📊 OPERA |
| Water Solubility | 0 mol/L📊 OPERA |
| Henry's Law Constant | 0 atm-m3/mole📊 OPERA |
Transport Properties
| Vapor Pressure | 0.001 mmHg📊 OPERA |
| Surface Tension | 32.598 dyn/cm📊 OPERA |
| Thermal Conductivity | 116.919 mW/(m*K)📊 OPERA |
Molecular Descriptors
| Topological Polar Surface Area | 17.07 Ų💻 Computed |
| H-Bond Donors | 0 count💻 Computed |
| H-Bond Acceptors | 1 count💻 Computed |
| Rotatable Bonds | 1 count💻 Computed |
| Aromatic Rings | 0 count💻 Computed |
| Molar Refractivity | 71.604 cm^3/mol📊 OPERA |
| Polarizability | 28.386 Å^3📊 OPERA |
Data Sources:
🔬 EPA Experimental data from U.S. EPA CompTox Chemicals Dashboard & CTX APIs. 📊 OPERA Predicted using EPA's OPERA QSAR models. 💻 Computed Calculated from SMILES using RDKit.
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