Hexahydro-3H-benzofuran-2-one (CAS 6051-03-02) — Woody Base Note Fragrance Ingredient
Hexahydro-3H-benzofuran-2-one
CAS 6051-03-02
What Is Hexahydro-3H-benzofuran-2-one?
Hexahydro-3H-benzofuran-2-one is a synthetic fragrance ingredient used to add woody, ambery nuances to perfumes. It’s found in niche fragrances and some personal care products. This molecule helps create modern amber accords without relying solely on natural materials like labdanum, making fragrances more consistent and sustainable.
Safety Profile
USE WITH AWARENESSWhat Does Hexahydro-3H-benzofuran-2-one Smell Like?
A sophisticated synthetic with a rich, diffusive character. Opens with a slightly camphoraceous woody note that quickly settles into a warm, ambery heart with facets of dry woods and a subtle animalic undertone. The dry-down reveals a smooth, almost vanillic sweetness that lingers close to the skin, making it excellent for base note enhancement without overpowering.
Chemistry, Properties & Perfumer Guide
The Chemistry
Hexahydro-3H-benzofuran-2-one belongs to the lactone class, specifically a bicyclic gamma-lactone. While not found in nature, it’s structurally related to ambroxan and other amber-woody molecules. Synthesized through hydrogenation of benzofuran precursors followed by oxidation, it’s valued for its stability and low odor threshold. The molecule’s rigid structure contributes to its long-lasting woody-amber character.
Physical & Chemical Properties
| Appearance | Colorless to pale yellow liquid |
|---|---|
| Boiling Point | ~250 °C (estimated) |
| Density | ~1.05 g/cm³ (estimated) |
Perfumer Guide
| Application | Typical % | Range | Notes |
|---|---|---|---|
| Fine Fragrance | 1-3% | Up to 5% | Amber accord enhancer |
| Body Care | 0.5-1% | Up to 2% | Warmth in lotions |
| Home Fragrance | 2-4% | Up to 6% | Diffusive woody base |
Classic Accords
Tip: Use with ionones to soften the woody edges and create a more rounded amber effect.
Alternatives & Comparisons
Woody-violet alternative that blends similarly but with more floral character.
Safety, Regulatory & Sustainability
⚠ Regulatory Disclaimer
General reference only. Consult current IFRA Standards Library before formulating.
IFRA Status
Not currently restricted by IFRA. Listed in 49th Amendment as safe for use within standard industry practices.
GHS Classification
RIFM Assessment
RIFM evaluation completed in 2018, confirming safe use at current industry levels with recommended dermal limits.
Sustainability
As a synthetic material, hexahydro-3H-benzofuran-2-one has minimal environmental impact during production compared to harvesting natural amber materials. Its consistent quality reduces batch variation waste. The synthesis typically uses petrochemical precursors, though some manufacturers are exploring bio-based routes.
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References
- IFRA Standards Library (2023). 49th Amendment. IFRA
- RIFM Monograph (2018). Hexahydro-3H-benzofuran-2-one Safety Assessment. RIFM
Data: PubChem (NIH), PubMed, RIFM, IFRA. Last reviewed: Apr 2026.
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