l-Menthol ethylene glycol carbonate (CAS 156324-78-6) — Green Base Note Fragrance Ingredient

ByThe Good Scents
Green · Citrus

l-Menthol ethylene glycol carbonate

CAS 156324-78-6

Origin
synthetic
Note
Base
IFRA
Generally safe
Data as of: Apr 2026

What Is l-Menthol ethylene glycol carbonate?

l-Menthol ethylene glycol carbonate is a synthetic cooling agent used in personal care products like lip balms and muscle rubs. It provides a sustained cooling sensation without the volatility of regular menthol. This ingredient matters because it offers longer-lasting effects than traditional cooling compounds, making it valuable in products designed for prolonged relief or sensory experiences.

Safety Profile

GENERALLY SAFE
Generally safeUse with awarenessProfessional use
✓ Safe in regulated products
⚠ Avoid contact with eyes
CAS
156324-78-6
Formula
Mixture
MW
Variable
Odor Family
Green · Citrus
Layer 1 · Enthusiast

What Does l-Menthol ethylene glycol carbonate Smell Like?

l-Menthol ethylene glycol carbonate delivers a clean, crisp cooling sensation reminiscent of fresh winter air. Unlike traditional menthol, its effect is more gradual and sustained, evolving from an initial sharp chill to a lingering coolness. The absence of strong odor allows it to blend seamlessly into formulations without overpowering other notes.

Scent Profile

In Famous Fragrances

Fragrance associations may not reflect actual formulations.

Cool Wave(Generic, 2010)

Used for its prolonged cooling effect in aftershaves and body sprays, providing a refreshing sensation without strong menthol odor.

Layer 2

Chemistry, Properties & Perfumer Guide

The Chemistry

l-Menthol ethylene glycol carbonate is a synthetic derivative of menthol, created by reacting menthol with ethylene glycol carbonate. This modification enhances its stability and prolongs its cooling effect. The compound retains the stereochemistry of l-menthol, which is crucial for its cooling properties.

Physical & Chemical Properties

AppearanceColorless to pale yellow liquid
Boiling PointNot available
Melting PointNot available

Perfumer Guide

Note Position
Base
Volatility
Low
Blending
Good
ApplicationTypical %RangeNotes
Personal Care1-3%Up to 5%Provides sustained cooling
Medicinal2-5%Up to 10%Used in muscle rubs and analgesic creams

Classic Accords

Tip: Use in combination with other cooling agents for synergistic effects.

Alternatives & Comparisons

1
Menthol CAS 89-78-1

Traditional cooling agent with stronger initial impact but shorter duration.

2
WS-3 CAS 39711-79-0

Synthetic coolant with similar properties but different chemical structure.

Layer 3

Safety, Regulatory & Sustainability

⚠ Regulatory Disclaimer

General reference only. Consult current IFRA Standards Library before formulating.

IFRA Status

Not restricted by IFRA.

RIFM Assessment

No specific RIFM assessment found.

Sustainability

As a synthetic compound, its production is controlled and does not rely on natural resources. However, the environmental impact depends on the manufacturing process and waste management.

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References

  1. PubChem PubChem

Data: PubChem (NIH), PubMed, RIFM, IFRA. Last reviewed: Apr 2026.

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