1-Cyclopropylmethyl-4-methoxybenzene (CAS 16510-27-3) — Woody Middle Note Fragrance Ingredient
1-Cyclopropylmethyl-4-methoxybenzene
CAS 16510-27-3
What Is 1-Cyclopropylmethyl-4-methoxybenzene?
1-Cyclopropylmethyl-4-methoxybenzene is a synthetic fragrance ingredient used in modern perfumery. It’s found in niche and experimental fragrances, often as a modifier for aromatic compositions. This molecule matters because it offers perfumers a unique aromatic profile that bridges herbal and woody notes, creating depth in contemporary scent designs.
Safety Profile
GENERALLY SAFEWhat Does 1-Cyclopropylmethyl-4-methoxybenzene Smell Like?
1-Cyclopropylmethyl-4-methoxybenzene presents a crisp, aromatic opening with a herbal-woody character reminiscent of crushed eucalyptus leaves and fresh pine needles. The initial sharpness mellows into a warm, slightly sweet heart note with subtle spicy undertones. In dry-down, it reveals a clean, almost camphoraceous quality that blends well with woody bases. The overall effect is reminiscent of a sun-warmed herb garden with a modern, slightly metallic edge.
In Famous Fragrances
Fragrance associations may not reflect actual formulations.
Used as a structural element to create an avant-garde aromatic foundation, lending both freshness and depth to this conceptual fragrance.
Provides a crisp counterpoint to sandalwood and vetiver, adding dimension to the woody accord without overwhelming the composition.
2D Molecular Structure
SMILES: COC1=CC=C(CC2CC2)C=C1
Chemistry, Properties & Perfumer Guide
The Chemistry
1-Cyclopropylmethyl-4-methoxybenzene belongs to the class of aromatic ethers, specifically a methoxybenzene derivative with a cyclopropylmethyl substituent. The molecule features a benzene ring with methoxy group at the para position and a cyclopropylmethyl group at the opposite position. Synthesis typically involves Williamson ether synthesis or Friedel-Crafts alkylation of anisole. The cyclopropyl ring introduces steric constraints that influence both the molecule’s volatility and odor characteristics.
Physical & Chemical Properties
| Appearance | Colorless to pale yellow liquid |
|---|---|
| Molecular Weight | 162.23 g/mol |
Perfumer Guide
| Application | Typical % | Range | Notes |
|---|---|---|---|
| Fine Fragrance | 1-3% | Up to 5% | Used as aromatic modifier |
| Functional Fragrance | 0.5-2% | Up to 3% | Adds freshness to cleaning products |
Classic Accords
Tip: Use sparingly in woody compositions to add lift without dominating the blend.
Alternatives & Comparisons
Anisic floral alternative with similar aromatic properties but sweeter profile.
Safety, Regulatory & Sustainability
⚠ Regulatory Disclaimer
General reference only. Consult current IFRA Standards Library before formulating.
IFRA Status
Not currently restricted by IFRA.
RIFM Assessment
No RIFM assessment found for this specific compound.
Sustainability
As a synthetic material, 1-Cyclopropylmethyl-4-methoxybenzene has minimal environmental impact in production compared to natural extracts. Its efficient synthesis reduces resource consumption, though like all synthetic aromatics, petrochemical feedstocks are typically required. The material’s potency allows for low usage levels, further reducing environmental burden.
Explore 1-Cyclopropylmethyl-4-methoxybenzene
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References
- Burdock, G.A. (2010). Fenaroli’s Handbook of Flavor Ingredients. CRC Press.
Data: PubChem (NIH), PubMed, RIFM, IFRA. Last reviewed: Apr 2026.
Report a data errorPhysicochemical Properties
DTXSID: DTXSID1051773
Physical Properties
| Molecular Weight | 162.232 g/mol🔬 EPA CompTox |
| Density | 0.99 g/cm^3🔬 EPA CTX |
| Boiling Point | 234.85 °C🔬 EPA CTX |
| Melting Point | -23.15 °C🔬 EPA CTX |
| Flash Point | 113 °C🔬 EPA CTX |
| Refractive Index | 1.552 Dimensionless📊 OPERA |
| Molar Volume | 155.543 cm^3/mol📊 OPERA |
Partition & Solubility
| LogP (Octanol-Water) | 3.698 Log10 unitless📊 OPERA |
| LogD (pH 5.5) | 3.698 Log10 unitless📊 OPERA |
| LogD (pH 7.4) | 3.698 Log10 unitless📊 OPERA |
| LogKoa (Octanol-Air) | 5.8 Log10 unitless📊 OPERA |
| Water Solubility | 0 mol/L🔬 EPA CTX |
| Henry's Law Constant | 0 atm-m3/mole📊 OPERA |
Transport Properties
| Vapor Pressure | 0.008 mmHg🔬 EPA CTX |
| Viscosity | 4.426 cP📊 OPERA |
| Surface Tension | 35.81 dyn/cm📊 OPERA |
| Thermal Conductivity | 129.412 mW/(m*K)📊 OPERA |
Molecular Descriptors
| Topological Polar Surface Area | 9.23 Ų💻 Computed |
| H-Bond Donors | 0 count💻 Computed |
| H-Bond Acceptors | 1 count💻 Computed |
| Rotatable Bonds | 3 count💻 Computed |
| Aromatic Rings | 1 count💻 Computed |
| Molar Refractivity | 49.68 cm^3/mol📊 OPERA |
| Polarizability | 19.695 Å^3📊 OPERA |
Data Sources:
🔬 EPA Experimental data from U.S. EPA CompTox Chemicals Dashboard & CTX APIs. 📊 OPERA Predicted using EPA's OPERA QSAR models. 💻 Computed Calculated from SMILES using RDKit.
