2-(1,1,2,3,3-Pentamethylindan-5-yl)-1-propanol (CAS 1217-08-09) — Musky Base Note Fragrance Ingredient

Musky · Woody

2-(1,1,2,3,3-Pentamethylindan-5-yl)-1-propanol

CAS 1217-08-09

Origin
synthetic
Note
Base
IFRA
Use with awareness
Data as of: Apr 2026

What Is 2-(1,1,2,3,3-Pentamethylindan-5-yl)-1-propanol?

2-(1,1,2,3,3-Pentamethylindan-5-yl)-1-propanol is a synthetic musk compound used in modern perfumery. It’s found in laundry detergents, fabric softeners, and personal care products where long-lasting fragrance is desired. This ingredient matters because it provides a clean, musky backbone to fragrances, enhancing their longevity without the environmental concerns of some traditional musks.

Safety Profile

USE WITH AWARENESS
Generally safeUse with awarenessProfessional use
Approved for use in consumer products
Potential bioaccumulation concerns
CAS
1217-08-09
Formula
Mixture
MW
Variable
Odor Family
Musky · Woody
Layer 1 · Enthusiast

What Does 2-(1,1,2,3,3-Pentamethylindan-5-yl)-1-propanol Smell Like?

This synthetic musk presents as a clean, soft, and slightly powdery odor with subtle woody undertones. Unlike animalic musks, it lacks the heavy sweat nuances, instead offering a laundry-fresh character that evolves into a skin-like warmth during dry-down. The scent profile is linear with excellent tenacity, making it ideal for base note applications where subtle persistence is desired.

Scent Profile
Layer 2

Chemistry, Properties & Perfumer Guide

The Chemistry

2-(1,1,2,3,3-Pentamethylindan-5-yl)-1-propanol belongs to the indane musk family, a class of synthetic musks developed as alternatives to nitro musks. Its structure features a pentamethylindane core with a propanol side chain, creating a compact yet voluminous molecule. Synthesis typically involves Friedel-Crafts alkylation of indane derivatives followed by side chain modifications. The multiple methyl groups contribute to its volatility profile and odor characteristics.

Physical & Chemical Properties

Perfumer Guide

Note Position
Base
Volatility
Very low (days)
Blending
Good
ApplicationTypical %RangeNotes
Fine Fragrance1-3%Up to 5%Base note fixative
Laundry Care0.5-1.5%Up to 2%Fabric substantivity
Personal Care0.1-0.5%Up to 1%Skin-friendly musk

Classic Accords

Tip: Use as a base note blender to add subtle muskiness without overwhelming other ingredients.

Alternatives & Comparisons

1
Galaxolide CAS 1222-05-5

A more potent white musk with higher substantivity, used when stronger musk presence is needed.

2
Ethylene Brassylate CAS 105-95-3

Softer, more floral musk alternative for delicate formulations.

Layer 3

Safety, Regulatory & Sustainability

⚠ Regulatory Disclaimer

General reference only. Consult current IFRA Standards Library before formulating.

IFRA Status

Not currently restricted by IFRA. Included in 51st Amendment for monitoring.

RIFM Assessment

Under review by RIFM for environmental persistence assessment.

Sustainability

As a synthetic musk, this compound avoids the ethical concerns of animal-derived musks but raises questions about environmental persistence. Manufacturers are developing biodegradable variants while maintaining performance. Current production uses petrochemical feedstocks, though bio-based routes are being explored.

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References

    Data: PubChem (NIH), PubMed, RIFM, IFRA. Last reviewed: Apr 2026.

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