Methyl 2,4-dihydroxy-m-toluate (CAS 33662-58-7) — Woody Middle to Base Note Fragrance Ingredient
Methyl 2,4-dihydroxy-m-toluate
CAS 33662-58-7
What Is Methyl 2,4-dihydroxy-m-toluate?
Methyl 2,4-dihydroxy-m-toluate is a synthetic fragrance ingredient used in perfumery to add depth and character to compositions. While not commonly recognized by name, it may appear in fine fragrances and personal care products. This compound matters because it helps perfumers create unique scent profiles, often contributing to the middle or base notes of a fragrance where longevity and complexity are key.
Safety Profile
GENERALLY SAFEWhat Does Methyl 2,4-dihydroxy-m-toluate Smell Like?
Methyl 2,4-dihydroxy-m-toluate offers a nuanced olfactory profile, blending subtle woody and slightly sweet undertones with a hint of phenolic sharpness. Its aroma evolves from a crisp, almost medicinal opening to a warmer, more rounded dry-down, making it a versatile tool for perfumers seeking to add depth without overwhelming the composition. The scent lingers subtly, enhancing the overall harmony of a fragrance.
In Famous Fragrances
Fragrance associations may not reflect actual formulations.
Used as a subtle modifier to enhance the woody and slightly sweet facets of the fragrance, adding depth without dominating the composition.
Employed to bridge the gap between fresh top notes and deep base notes, providing a smooth transition and longevity.
2D Molecular Structure
SMILES: COC(=O)C1=C(O)C(C)=C(O)C=C1
Chemistry, Properties & Perfumer Guide
The Chemistry
Methyl 2,4-dihydroxy-m-toluate is a synthetic aromatic ester, derived from the esterification of a dihydroxy-toluic acid with methanol. Its structure features a benzene ring with hydroxyl and methoxycarbonyl substituents, contributing to its unique scent profile. The compound is typically synthesized in controlled laboratory settings, ensuring purity and consistency for perfumery applications.
Physical & Chemical Properties
| Boiling Point | Not available |
|---|---|
| Density | Not available |
Perfumer Guide
| Application | Typical % | Range | Notes |
|---|---|---|---|
| Fine Fragrance | 1-3% | Up to 5% | Adds depth and complexity |
| Personal Care | 0.5-2% | Up to 3% | Used for subtle scent enhancement |
Classic Accords
Tip: Use sparingly to avoid overpowering other notes; best in blends where subtlety is desired.
Alternatives & Comparisons
Offers a similar phenolic sweetness but with a more pronounced wintergreen character.
Provides a sweeter, more vanilla-like profile when a less phenolic note is needed.
Safety, Regulatory & Sustainability
⚠ Regulatory Disclaimer
General reference only. Consult current IFRA Standards Library before formulating.
IFRA Status
No restrictions under current IFRA standards.
RIFM Assessment
Currently under review by RIFM for comprehensive safety assessment.
Sustainability
As a synthetic compound, Methyl 2,4-dihydroxy-m-toluate is produced in laboratories, minimizing environmental impact compared to natural extracts. Its synthesis can be optimized for reduced waste and energy consumption, aligning with green chemistry principles.
Explore Methyl 2,4-dihydroxy-m-toluate
Browse essential oils and aroma compounds.
Browse on iHerb →Affiliate disclosure: we may earn a small commission at no extra cost to you.
References
- PubChem Compound Summary for Methyl 2,4-dihydroxy-m-toluate PubChem
Data: PubChem (NIH), PubMed, RIFM, IFRA. Last reviewed: Apr 2026.
Report a data errorIngredient Data Sheet
CAS 33662-58-7Physical Properties
| Molecular Weight | 182.17 g/mol🔬 PubChem |
| LogP (Octanol-Water) | 2🔬 PubChem |
| log Kp (skin permeability) | -2.391💻 Calculated |
| SMILES | CC1=C(C=CC(=C1O)C(=O)OC)O🔬 PubChem |
Odor & Flavor
| Primary Descriptors | sweetwoody• leffingwell |
| Functional Groups | esterphenoletheraromatic💻 RDKit |
Physical data: PubChem (NIH/NLM), U.S. EPA CompTox Dashboard, EPA OPERA models, RDKit. Odor & flavor: Arctander (Perfume & Flavor Chemicals), Fenaroli's Handbook of Flavor Ingredients, Leffingwell. Thresholds: van Gemert (Compilations of Odour Threshold Values). Regulatory: IFRA Standards 51st, FEMA GRAS. Trade names: Surburg (Common Fragrance & Flavor Materials). All data compiled and cross-referenced for perfumertools.com.
Physicochemical Properties
DTXSID: DTXSID3067782
Physical Properties
| Molecular Weight | 182.175 g/mol🔬 EPA CompTox |
| Density | 1.287 g/cm^3📊 OPERA |
| Boiling Point | 313.5 °C📊 OPERA |
| Melting Point | 106.567 °C📊 OPERA |
| Flash Point | 142.478 °C📊 OPERA |
| Refractive Index | 1.578 Dimensionless📊 OPERA |
| Molar Volume | 140.461 cm^3/mol📊 OPERA |
Partition & Solubility
| LogP (Octanol-Water) | 2.127 Log10 unitless📊 OPERA |
| LogD (pH 5.5) | 2.122 Log10 unitless📊 OPERA |
| LogD (pH 7.4) | 1.91 Log10 unitless📊 OPERA |
| LogKoa (Octanol-Air) | 7.92 Log10 unitless📊 OPERA |
| Water Solubility | 0.017 mol/L📊 OPERA |
| Henry's Law Constant | 0 atm-m3/mole📊 OPERA |
Transport Properties
| Vapor Pressure | 0 mmHg📊 OPERA |
| Viscosity | 14.168 cP📊 OPERA |
| Surface Tension | 47.036 dyn/cm📊 OPERA |
| Thermal Conductivity | 155.004 mW/(m*K)📊 OPERA |
Molecular Descriptors
| Topological Polar Surface Area | 66.76 Ų💻 Computed |
| H-Bond Donors | 2 count💻 Computed |
| H-Bond Acceptors | 4 count💻 Computed |
| Rotatable Bonds | 1 count💻 Computed |
| Aromatic Rings | 1 count💻 Computed |
| Molar Refractivity | 46.614 cm^3/mol📊 OPERA |
| Polarizability | 18.479 Å^3📊 OPERA |
Data Sources:
🔬 EPA Experimental data from U.S. EPA CompTox Chemicals Dashboard & CTX APIs. 📊 OPERA Predicted using EPA's OPERA QSAR models. 💻 Computed Calculated from SMILES using RDKit.
![1-Oxaspiro[4.5]deca-3,6-diene, 2,7-dimethyl-10-(1-methylethyl)- (CAS 89079-92-5) — Woody Base Note Fragrance Ingredient](https://thegoodscents.company/wp-content/uploads/2026/04/1-oxaspiro-4-5-deca-3-6-diene-2-7-dimethyl-10-1-1-768x439.webp)
