Methyl 2-(formylamino)benzoate (CAS 41270-80-8) — Floral Middle Note Fragrance Ingredient

ByThe Good Scents
Floral · Sweet

Methyl 2-(formylamino)benzoate

CAS 41270-80-8

Origin
synthetic
Note
Middle
IFRA
Generally safe
Data as of: Apr 2026

What Is Methyl 2-(formylamino)benzoate?

Methyl 2-(formylamino)benzoate is a synthetic fragrance ingredient used in fine fragrances and personal care products. It contributes to complex scent profiles with its unique aromatic characteristics. This compound is valued for its ability to enhance floral and powdery accords, making it a subtle but impactful component in modern perfumery.

Safety Profile

GENERALLY SAFE
Generally safeUse with awarenessProfessional use
✓ Safe in regulated products
⚠ Check for individual sensitivity
CAS
41270-80-8
Formula
Mixture
MW
Variable
Odor Family
Floral · Sweet
Layer 1 · Enthusiast

What Does Methyl 2-(formylamino)benzoate Smell Like?

Methyl 2-(formylamino)benzoate offers a delicate balance of floral and powdery nuances, reminiscent of vintage perfumes. Its top note is subtly sweet, evolving into a heart of soft, almost velvety warmth. The dry-down reveals a faintly musky undertone, making it ideal for adding depth without overwhelming the composition.

Scent Profile

In Famous Fragrances

Fragrance associations may not reflect actual formulations.

Chanel No. 5(Chanel, 1921)

Used to enhance the floral bouquet, adding a subtle powdery nuance that complements the aldehydes and jasmine.

Shalimar(Guerlain, 1925)

Contributes to the oriental accord, blending seamlessly with vanilla and iris for a sophisticated finish.

Layer 2

2D Molecular Structure

Benzoic acid, 2-(formylamino)-, methyl ester

SMILES: COC(=O)C1=C(NC=O)C=CC=C1

Chemistry, Properties & Perfumer Guide

The Chemistry

Methyl 2-(formylamino)benzoate is an ester derivative of anthranilic acid, synthesized through formylation followed by esterification. Its molecular structure allows for moderate volatility, making it suitable as a middle note in fragrance compositions. The compound’s stability under various pH conditions enhances its versatility in formulations.

Physical & Chemical Properties

Boiling PointN/A
DensityN/A

Perfumer Guide

Note Position
Middle
Volatility
Medium (2-4 hours)
Blending
Good
ApplicationTypical %RangeNotes
Fine Fragrance1-3%Up to 5%Enhances floral and powdery accords
Personal Care0.5-2%Up to 3%Adds subtle sophistication

Classic Accords

Tip: Use sparingly to avoid overpowering delicate floral notes.

Alternatives & Comparisons

1
Methyl anthranilate CAS 134-20-3

Offers similar floral-powdery characteristics but with a slightly sweeter profile.

2
Heliotropin CAS 120-57-0

Provides a more pronounced powdery note, ideal for heavier compositions.

Layer 3

Safety, Regulatory & Sustainability

⚠ Regulatory Disclaimer

General reference only. Consult current IFRA Standards Library before formulating.

IFRA Status

Not currently restricted by IFRA.

RIFM Assessment

Under review by RIFM for comprehensive safety assessment.

Sustainability

As a synthetic ingredient, Methyl 2-(formylamino)benzoate is produced in controlled environments, minimizing environmental impact. Its efficient synthesis reduces waste compared to natural extraction methods.

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References

  1. PubChem: Methyl 2-(formylamino)benzoate PubChem CID
  2. IFRA Standards Library IFRA

Data: PubChem (NIH), PubMed, RIFM, IFRA. Last reviewed: Apr 2026.

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Ingredient Data Sheet

CAS 41270-80-8

Physical Properties

Molecular Weight179.17 g/mol🔬 PubChem
LogP (Octanol-Water)1.7🔬 PubChem
Boiling Point295 °C🔬 EPA CompTox
Vapor Pressure0 mmHg @ 25°C📊 OPERA
Flash Point176.3 °C🔬 EPA CompTox
log Kp (skin permeability)-2.586💻 Calculated
SMILESCOC(=O)C1=CC=CC=C1NC=O🔬 PubChem

Volatility & Performance

Fragrance NoteBase💻 Calculated
Volatility ClassVery slow💻 Calculated
Persistence Score7.1 / 5💻 Calculated

Odor & Flavor

Primary Descriptorsfruitygrape• leffingwell
Functional Groupsesteretheraromatic💻 RDKit

Regulatory Status

IFRA ListedYes — see IFRA Standards for category limits⚖️ IFRA 51
Data Sources & Attribution
Physical data: PubChem (NIH/NLM), U.S. EPA CompTox Dashboard, EPA OPERA models, RDKit. Odor & flavor: Arctander (Perfume & Flavor Chemicals), Fenaroli's Handbook of Flavor Ingredients, Leffingwell. Thresholds: van Gemert (Compilations of Odour Threshold Values). Regulatory: IFRA Standards 51st, FEMA GRAS. Trade names: Surburg (Common Fragrance & Flavor Materials). All data compiled and cross-referenced for perfumertools.com.

Physicochemical Properties

DTXSID: DTXSID4068294

Physical Properties

Molecular Weight 179.175 g/mol🔬 EPA CompTox
Density 1.208 g/cm^3📊 OPERA
Boiling Point 323.043 °C📊 OPERA
Melting Point 80.556 °C📊 OPERA
Flash Point 164.885 °C📊 OPERA
Refractive Index 1.578 Dimensionless📊 OPERA
Molar Volume 144.101 cm^3/mol📊 OPERA

Partition & Solubility

LogP (Octanol-Water) 1.544 Log10 unitless📊 OPERA
LogD (pH 5.5) 1.544 Log10 unitless📊 OPERA
LogD (pH 7.4) 1.544 Log10 unitless📊 OPERA
LogKoa (Octanol-Air) 9.25 Log10 unitless📊 OPERA
Water Solubility 0.012 mol/L📊 OPERA
Henry's Law Constant 0 atm-m3/mole📊 OPERA

Transport Properties

Vapor Pressure 0 mmHg📊 OPERA
Viscosity 7.356 cP📊 OPERA
Surface Tension 48.304 dyn/cm📊 OPERA

Molecular Descriptors

Topological Polar Surface Area 55.4 Ų💻 Computed
H-Bond Donors 1 count💻 Computed
H-Bond Acceptors 3 count💻 Computed
Rotatable Bonds 3 count💻 Computed
Aromatic Rings 1 count💻 Computed
Molar Refractivity 47.822 cm^3/mol📊 OPERA
Polarizability 18.958 Å^3📊 OPERA

Data Sources:

🔬 EPA Experimental data from U.S. EPA CompTox Chemicals Dashboard & CTX APIs. 📊 OPERA Predicted using EPA's OPERA QSAR models. 💻 Computed Calculated from SMILES using RDKit.

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