Octyl butyrate (CAS 110-39-4) — Sweet Top to middle Note Fragrance Ingredient

Sweet · Citrus

Octyl butyrate

CAS 110-39-4

Origin
synthetic
Note
Top to middle
IFRA
Generally safe
Data as of: Apr 2026

What Is Octyl butyrate?

Octyl butyrate is a synthetic ester commonly found in fruit-flavored foods and perfumes. It delivers a sweet, fruity aroma reminiscent of ripe peaches and oranges. This versatile ingredient matters because it adds natural-smelling fruitiness to products without relying on actual fruit extracts, making fragrances more affordable and stable.

Safety Profile

GENERALLY SAFE
Generally safeUse with awarenessProfessional use
GRAS (Generally Recognized As Safe) for food use
No known skin sensitization concerns
CAS
110-39-4
Formula
Mixture
MW
Variable
Odor Family
Sweet · Citrus
Layer 1 · Enthusiast

What Does Octyl butyrate Smell Like?

Octyl butyrate bursts with a juicy, tropical fruit character – imagine biting into a perfectly ripe peach with hints of pineapple and orange marmalade. The top note is bright and slightly citrusy, evolving into a heart of creamy apricot nectar. As it dries down, it leaves a soft, waxy-fruity trail reminiscent of fruit-scented lip balm. The sweetness is candied but never cloying, with a clean finish that prevents it from becoming syrupy.

Scent Profile

In Famous Fragrances

Fragrance associations may not reflect actual formulations.

Peche Cardinal(MDCI, 2008)

Octyl butyrate provides the luscious peach skin accord that makes this fragrance so mouthwatering. It blends seamlessly with osmanthus and coconut to create a tropical fruit fantasy.

Bitter Peach(Tom Ford, 2020)

Used here to amplify the ripe fruit character against patchouli’s darkness. The octyl butyrate adds a juicy realism that prevents the peach note from becoming too candied.

Layer 2

2D Molecular Structure

Butanoic acid, octyl ester

SMILES: CCCCCCCCOC(=O)CCC

Chemistry, Properties & Perfumer Guide

The Chemistry

Octyl butyrate is an ester formed from butyric acid and octanol. While found naturally in some fruits, commercial production typically involves acid-catalyzed esterification of the two components. The molecular structure features an eight-carbon chain (octyl group) esterified to a four-carbon butyrate moiety, creating optimal volatility for fragrance use. Its relatively simple structure makes it inexpensive to produce while delivering complex fruity olfactory effects.

Physical & Chemical Properties

Boiling Point198 °C
Density0.865 g/cm³

Perfumer Guide

Note Position
Top to middle
Volatility
Medium (1-3 hours)
Blending
Good
ApplicationTypical %RangeNotes
Fine Fragrance0.5-2%Up to 5%Fruit accord enhancer
Functional Fragrance0.1-0.5%Up to 1%Soap/shampoo fruity notes

Classic Accords

+ Aldehyde C-14 + Gamma Undecalactone = Peach + Ethyl Maltol + Vanillin = Fruit candy

Tip: Use with ionones to create more natural-smelling fruit effects.

Alternatives & Comparisons

1
Hexyl butyrate CAS 2639-63-6

Shorter carbon chain creates brighter, greener fruit character. Use when needing more freshness in fruit accords.

Layer 3

Safety, Regulatory & Sustainability

⚠ Regulatory Disclaimer

General reference only. Consult current IFRA Standards Library before formulating.

IFRA Status

No restrictions under IFRA standards.

RIFM Assessment

RIFM evaluation confirms safe use at current levels in fragrance applications.

Sustainability

As a synthetic material, octyl butyrate has minimal environmental impact in production. It reduces pressure on natural resources by providing fruit effects without requiring agricultural land. The manufacturing process uses common petrochemical feedstocks with established recycling protocols for byproducts.

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References

  1. Burdock, G.A. (2010). Fenaroli’s Handbook of Flavor Ingredients. CRC Press. PMID 30000922

Data: PubChem (NIH), PubMed, RIFM, IFRA. Last reviewed: Apr 2026.

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Ingredient Data Sheet

CAS 110-39-4

Physical Properties

Molecular Weight200.32 g/mol🔬 PubChem
LogP (Octanol-Water)4.2🔬 PubChem
Boiling Point224 °C🔬 EPA CompTox
Flash Point103.3 °C🔬 EPA CompTox
log Kp (skin permeability)-0.94💻 Calculated
SMILESCCCCCCCCOC(=O)CCC🔬 PubChem

Volatility & Performance

Fragrance NoteHeart💻 Calculated

Odor & Flavor

Primary Descriptorsfattyfloralfruitygreenherbal• leffingwell
Functional Groupsesterether💻 RDKit
Octyl butyrate has a green, herbaceous odor remotely reminiscent of orange, but more so of galbanum and parsley and a sweet, melon-like flavor.📖 Fenaroli

Sensory Thresholds

Odor Detection Threshold1.4318 ppm (n=2)📖 van Gemert

Regulatory Status

IOFI ClassificationNature Identical📖 Fenaroli
Data Sources & Attribution
Physical data: PubChem (NIH/NLM), U.S. EPA CompTox Dashboard, EPA OPERA models, RDKit. Odor & flavor: Arctander (Perfume & Flavor Chemicals), Fenaroli's Handbook of Flavor Ingredients, Leffingwell. Thresholds: van Gemert (Compilations of Odour Threshold Values). Regulatory: IFRA Standards 51st, FEMA GRAS. Trade names: Surburg (Common Fragrance & Flavor Materials). All data compiled and cross-referenced for perfumertools.com.

Physicochemical Properties

DTXSID: DTXSID9059387

Physical Properties

Molecular Weight 200.322 g/mol🔬 EPA CompTox
Density 0.855 g/cm^3🔬 EPA CTX
Boiling Point 234.55 °C🔬 EPA CTX
Melting Point -55.6 °C🔬 EPA CTX
Flash Point 104.175 °C🔬 EPA CTX
Refractive Index 1.43 Dimensionless📊 OPERA
Molar Volume 230.099 cm^3/mol📊 OPERA

Partition & Solubility

LogP (Octanol-Water) 4.63 Log10 unitless📊 OPERA
LogD (pH 5.5) 4.63 Log10 unitless📊 OPERA
LogD (pH 7.4) 4.63 Log10 unitless📊 OPERA
LogKoa (Octanol-Air) 6.08 Log10 unitless📊 OPERA
Water Solubility 0 mol/L📊 OPERA
Henry's Law Constant 0 atm-m3/mole📊 OPERA

Transport Properties

Vapor Pressure 0.023 mmHg📊 OPERA
Viscosity 2.282 cP📊 OPERA
Surface Tension 28.22 dyn/cm📊 OPERA
Thermal Conductivity 140.05 mW/(m*K)📊 OPERA

Molecular Descriptors

Topological Polar Surface Area 26.3 Ų💻 Computed
H-Bond Donors 0 count💻 Computed
H-Bond Acceptors 2 count💻 Computed
Rotatable Bonds 9 count💻 Computed
Aromatic Rings 0 count💻 Computed
Molar Refractivity 59.418 cm^3/mol📊 OPERA
Polarizability 23.555 Å^3📊 OPERA

Data Sources:

🔬 EPA Experimental data from U.S. EPA CompTox Chemicals Dashboard & CTX APIs. 📊 OPERA Predicted using EPA's OPERA QSAR models. 💻 Computed Calculated from SMILES using RDKit.

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