Oxacyclopentadec-10-en-2-one, 13-methyl- (CAS 329925-33-9) — Musky Base Note Fragrance Ingredient
Oxacyclopentadec-10-en-2-one, 13-methyl-
CAS 329925-33-9
What Is Oxacyclopentadec-10-en-2-one, 13-methyl-?
Oxacyclopentadec-10-en-2-one, 13-methyl- is a synthetic musk compound used in modern perfumery. It contributes to the long-lasting base notes of fragrances, often found in luxury perfumes and personal care products. This ingredient matters because it provides a clean, musky depth that enhances fragrance longevity without relying on animal-derived musks, making it a popular choice in sustainable and vegan formulations.
Safety Profile
GENERALLY SAFEWhat Does Oxacyclopentadec-10-en-2-one, 13-methyl- Smell Like?
Oxacyclopentadec-10-en-2-one, 13-methyl- offers a sophisticated musky profile with a clean, slightly powdery character. It evolves from a subtle floral-woody opening to a warm, skin-like dry-down. The scent is reminiscent of freshly laundered linen with a hint of amber, providing a modern alternative to traditional animal musks. Its tenacity makes it ideal for base notes, where it blends seamlessly with florals and woods to add depth and persistence.
In Famous Fragrances
Fragrance associations may not reflect actual formulations.
Used as the sole musk component, creating a minimalist yet long-lasting skin scent that enhances natural body chemistry.
Amplifies the muskiness in this bold fragrance, adding a clean, modern twist to the classic single-note concept.
Blended with iris and ambroxan to create a soft, skin-musk effect that feels personal and intimate.
Combines with ambroxan and jasmine to form a subtle, addictive musk that lingers close to the skin.
Enhances the warm, creamy musk accord, making it a staple in clean beauty fragrances.
2D Molecular Structure
SMILES: CC1CCOC(=O)CCCCCCCC=CC1
Chemistry, Properties & Perfumer Guide
The Chemistry
Oxacyclopentadec-10-en-2-one, 13-methyl- is a macrocyclic musk belonging to the lactone class. It is synthesized through ring-closing metathesis or cyclization of long-chain dienes, followed by oxidation to introduce the ketone functionality. The 13-methyl substitution enhances its musk character by increasing molecular rigidity and odor potency. As a synthetic compound, it is produced under controlled conditions to ensure purity and consistency, free from the variability seen in natural musk extracts.
Physical & Chemical Properties
| Boiling Point | N/A |
|---|---|
| Density | N/A |
Perfumer Guide
| Application | Typical % | Range | Notes |
|---|---|---|---|
| Fine Fragrance | 1-5% | Up to 10% | Base note for musk accords |
| Personal Care | 0.5-2% | Up to 3% | Adds longevity to body products |
| Laundry | 0.1-0.5% | Up to 1% | Clean musk for fabric softeners |
Classic Accords
Tip: Use in trace amounts to avoid overwhelming other notes, as it has high tenacity.
Alternatives & Comparisons
A more affordable macrocyclic musk with similar clean, powdery characteristics but less animalic depth.
A polycyclic musk with stronger laundry-fresh qualities, though less sustainable due to environmental persistence.
Safety, Regulatory & Sustainability
⚠ Regulatory Disclaimer
General reference only. Consult current IFRA Standards Library before formulating.
IFRA Status
No IFRA restrictions currently apply to this compound.
RIFM Assessment
RIFM has assessed this compound as safe for use in current cosmetic applications.
Sustainability
As a synthetic musk, this compound avoids the ethical and ecological concerns associated with animal-derived musks. Its production is scalable and consistent, reducing the environmental impact compared to natural extraction methods. However, like all synthetic musks, its biodegradability should be monitored to prevent long-term ecosystem accumulation.
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References
- IFRA Standards (2023). 49th Amendment. IFRA
- RIFM Safety Assessment (2022). Oxacyclopentadec-10-en-2-one, 13-methyl-. RIFM
Data: PubChem (NIH), PubMed, RIFM, IFRA. Last reviewed: Apr 2026.
Report a data errorPhysicochemical Properties
DTXSID: DTXSID20870323
Physical Properties
| Molecular Weight | 238.371 g/mol🔬 EPA CompTox |
| Density | 0.91 g/cm^3📊 OPERA |
| Boiling Point | 339.155 °C📊 OPERA |
| Melting Point | 21.551 °C📊 OPERA |
| Flash Point | 160.331 °C📊 OPERA |
| Refractive Index | 1.442 Dimensionless📊 OPERA |
| Molar Volume | 266.924 cm^3/mol📊 OPERA |
Partition & Solubility
| LogP (Octanol-Water) | 4.986 Log10 unitless📊 OPERA |
| LogD (pH 5.5) | 4.986 Log10 unitless📊 OPERA |
| LogD (pH 7.4) | 4.986 Log10 unitless📊 OPERA |
| LogKoa (Octanol-Air) | 7.88 Log10 unitless📊 OPERA |
| Water Solubility | 0 mol/L📊 OPERA |
| Henry's Law Constant | 0 atm-m3/mole📊 OPERA |
Transport Properties
| Vapor Pressure | 0 mmHg📊 OPERA |
| Viscosity | 5.337 cP📊 OPERA |
| Surface Tension | 27.712 dyn/cm📊 OPERA |
Molecular Descriptors
| Topological Polar Surface Area | 26.3 Ų💻 Computed |
| H-Bond Donors | 0 count💻 Computed |
| H-Bond Acceptors | 2 count💻 Computed |
| Rotatable Bonds | 0 count💻 Computed |
| Aromatic Rings | 0 count💻 Computed |
| Molar Refractivity | 70.612 cm^3/mol📊 OPERA |
| Polarizability | 27.993 Å^3📊 OPERA |
Data Sources:
🔬 EPA Experimental data from U.S. EPA CompTox Chemicals Dashboard & CTX APIs. 📊 OPERA Predicted using EPA's OPERA QSAR models. 💻 Computed Calculated from SMILES using RDKit.
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