Oxacyclotridecan-2-one (CAS 0947-05-07) — Musky Base Note Fragrance Ingredient
Oxacyclotridecan-_2-_one
CAS 0947-05-07
What Is Oxacyclotridecan-_2-_one?
Oxacyclotridecan-2-one is a synthetic musk compound used in modern perfumery. It appears in laundry detergents, fabric softeners, and some musk-forward fragrances. This ingredient matters because it provides long-lasting musk notes without animal-derived materials, making it a sustainable alternative in clean musk accords.
Safety Profile
USE WITH AWARENESSWhat Does Oxacyclotridecan-_2-_one Smell Like?
Oxacyclotridecan-2-one delivers a clean, modern musk profile with a diffusive laundry-fresh character. The scent evolves from an initial crispness reminiscent of sun-dried cotton into a warm, skin-like musk dry-down. Unlike animalic musks, it maintains a bright, almost ozonic quality throughout its lifespan, making it ideal for contemporary clean fragrances.
Chemistry, Properties & Perfumer Guide
The Chemistry
Oxacyclotridecan-2-one belongs to the macrocyclic musk family, characterized by a 13-membered ring structure with an oxygen heteroatom. Synthesized through cyclization of long-chain diacids or hydroxy acids, this musk variant offers improved biodegradability compared to nitro musks. The oxygen incorporation enhances water solubility while maintaining musk-typical olfactory properties.
Physical & Chemical Properties
| Appearance | Colorless to pale yellow liquid |
|---|---|
| Molecular Weight | ~198 g/mol (estimated) |
Perfumer Guide
| Application | Typical % | Range | Notes |
|---|---|---|---|
| Fine Fragrance | 0.5-2% | Up to 5% | Musk foundation |
| Functional Products | 0.1-0.5% | Up to 1% | Fabric care applications |
Classic Accords
Tip: Use with ionones to create fabric-softener nostalgic effects.
Alternatives & Comparisons
More affordable macrocyclic musk with similar odor profile but slightly sweeter character.
Polycyclic musk alternative with stronger diffusion and laundry-type musk character.
Safety, Regulatory & Sustainability
⚠ Regulatory Disclaimer
General reference only. Consult current IFRA Standards Library before formulating.
IFRA Status
Not currently restricted under IFRA standards.
RIFM Assessment
Currently under review by RIFM for environmental persistence assessment.
Sustainability
As a synthetic musk, oxacyclotridecan-2-one avoids wildlife harvesting concerns associated with animal musks. However, its environmental persistence requires careful formulation to minimize ecological impact. Recent production methods focus on green chemistry principles to reduce energy consumption during synthesis.
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References
Data: PubChem (NIH), PubMed, RIFM, IFRA. Last reviewed: Apr 2026.
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