Phenylethyl anthranilate (CAS 133-18-6) — Sweet Heart Note Fragrance Ingredient
Phenylethyl anthranilate
CAS 133-18-6
What Is Phenylethyl anthranilate?
Phenylethyl anthranilate is a synthetic fragrance ingredient commonly found in perfumes and flavored products. It contributes a sweet, grape-like aroma with floral undertones. This versatile molecule matters because it’s used to create fruity-floral accords in fragrances and can enhance the natural sweetness of other ingredients.
Safety Profile
GENERALLY SAFEWhat Does Phenylethyl anthranilate Smell Like?
Phenylethyl anthranilate opens with an intense grape soda sweetness that quickly settles into a honeyed floral character reminiscent of orange blossoms. The dry-down reveals a subtle powdery nuance that blends beautifully with vanilla and amber bases. Its tenacity is moderate, acting as a bridge between top and heart notes, with a soft sillage that lingers close to the skin.
In Famous Fragrances
Fragrance associations may not reflect actual formulations.
Used here to amplify the jammy aspects of jasmine while adding a fruity dimension that contrasts with the dark woody base.
Contributes to the candied iris effect, blending with ethyl maltol to create the fragrance’s signature gourmand-floral accord.
2D Molecular Structure
SMILES: NC1=CC=CC=C1C(=O)OCCC1=CC=CC=C1
Chemistry, Properties & Perfumer Guide
The Chemistry
Phenylethyl anthranilate is an ester formed from phenethyl alcohol and anthranilic acid. As a synthetic material, it’s typically produced through Fischer esterification. The molecule features both aromatic and ester functional groups, which contribute to its stability and fragrance characteristics. Its relatively simple structure allows for cost-effective production while delivering complex olfactory effects.
Physical & Chemical Properties
| Appearance | Colorless to pale yellow liquid |
|---|---|
| Boiling Point | ~300°C (estimated) |
| Density | ~1.15 g/cm³ (estimated) |
Perfumer Guide
| Application | Typical % | Range | Notes |
|---|---|---|---|
| Fine Fragrance | 1-3% | Up to 5% | Used as floral-fruity modifier |
| Functional Fragrance | 0.5-1% | Up to 2% | For soap and detergent applications |
Classic Accords
Tip: Use with citrus top notes to create a grapefruit illusion without the volatility of actual citrus oils.
Alternatives & Comparisons
More grape-like and less sweet, better for citrus accords but lacks the floral depth of phenylethyl anthranilate.
Safety, Regulatory & Sustainability
⚠ Regulatory Disclaimer
General reference only. Consult current IFRA Standards Library before formulating.
IFRA Status
Not currently restricted by IFRA standards.
RIFM Assessment
Considered safe for use in current applications based on RIFM assessments.
Sustainability
As a synthetic material, phenylethyl anthranilate offers consistent quality without natural sourcing concerns. Production can be optimized for minimal environmental impact through green chemistry principles. Its efficiency in formulations means less material is needed compared to some natural alternatives.
Explore Phenylethyl anthranilate
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References
- Bauer, K. et al. (2001). Common Fragrance and Flavor Materials. Wiley-VCH.
Data: PubChem (NIH), PubMed, RIFM, IFRA. Last reviewed: Apr 2026.
Report a data errorIngredient Data Sheet
CAS 133-18-6Physical Properties
| Molecular Weight | 241.28 g/mol🔬 PubChem |
| LogP (Octanol-Water) | 4.2🔬 PubChem |
| Boiling Point | 342 °C🔬 EPA CompTox |
| Vapor Pressure | 0 mmHg @ 25°C📊 OPERA |
| Flash Point | 236.1 °C🔬 EPA CompTox |
| log Kp (skin permeability) | -1.19💻 Calculated |
| SMILES | C1=CC=C(C=C1)CCOC(=O)C2=CC=CC=C2N🔬 PubChem |
Volatility & Performance
| Fragrance Note | Base💻 Calculated |
Odor & Flavor
| Primary Descriptors | floralsweet• leffingwell |
| Functional Groups | esteretheraromaticamine💻 RDKit |
| “for its sweet-fruity floral effect in Gardenia, Honeysuckle, Violet, Plumeria (Frangipanni), etc. It blends very well with the Ionones and Methylionones for above purposes, and it should be kept in mind that this ester will form "Schiff's bases" with most aldehydes. Not all of these Schiff's bases are desirable – of color or odor.”📖 Arctander | |
Flavor Notes (Arctander)
| “The ester finds use in flavor compositions for its Grape- and Grapefruit-like effect, which is only obvious at very low concentrations. The taste is very perfumey at 20 ppm or higher, while near 1 ppm it becomes sweet and fruity, Grape-like, jam-like. It is also used in Butter flavors, Caramel and H”📖 Arctander |
Regulatory Status
| FEMA Number | FEMA 2859⚖️ FEMA GRAS |
| GRAS Status | Generally Recognized as Safe⚖️ FEMA GRAS |
Physical data: PubChem (NIH/NLM), U.S. EPA CompTox Dashboard, EPA OPERA models, RDKit. Odor & flavor: Arctander (Perfume & Flavor Chemicals), Fenaroli's Handbook of Flavor Ingredients, Leffingwell. Thresholds: van Gemert (Compilations of Odour Threshold Values). Regulatory: IFRA Standards 51st, FEMA GRAS. Trade names: Surburg (Common Fragrance & Flavor Materials). All data compiled and cross-referenced for perfumertools.com.
Physicochemical Properties
DTXSID: DTXSID5025861
Physical Properties
| Molecular Weight | 241.29 g/mol🔬 EPA CompTox |
| Density | 1.14 g/cm^3🔬 EPA CTX |
| Boiling Point | 371.093 °C📊 OPERA |
| Melting Point | 42 °C🔬 EPA CTX |
| Flash Point | 236.15 °C🔬 EPA CTX |
| Refractive Index | 1.607 Dimensionless📊 OPERA |
| Molar Volume | 206.815 cm^3/mol📊 OPERA |
Partition & Solubility
| LogP (Octanol-Water) | 2.964 Log10 unitless📊 OPERA |
| LogD (pH 5.5) | 2.938 Log10 unitless📊 OPERA |
| LogD (pH 7.4) | 2.964 Log10 unitless📊 OPERA |
| LogKoa (Octanol-Air) | 10.45 Log10 unitless📊 OPERA |
| Water Solubility | 0 mol/L📊 OPERA |
| Henry's Law Constant | 0 atm-m3/mole📊 OPERA |
Transport Properties
| Vapor Pressure | 0 mmHg📊 OPERA |
| Viscosity | 23.437 cP📊 OPERA |
| Surface Tension | 49.977 dyn/cm📊 OPERA |
| Thermal Conductivity | 155.211 mW/(m*K)📊 OPERA |
Molecular Descriptors
| Topological Polar Surface Area | 52.32 Ų💻 Computed |
| H-Bond Donors | 1 count💻 Computed |
| H-Bond Acceptors | 3 count💻 Computed |
| Rotatable Bonds | 4 count💻 Computed |
| Aromatic Rings | 2 count💻 Computed |
| Molar Refractivity | 71.382 cm^3/mol📊 OPERA |
| Polarizability | 28.298 Å^3📊 OPERA |
Data Sources:
🔬 EPA Experimental data from U.S. EPA CompTox Chemicals Dashboard & CTX APIs. 📊 OPERA Predicted using EPA's OPERA QSAR models. 💻 Computed Calculated from SMILES using RDKit.
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