S-Methyl thioacetate (CAS 1534-08-03) — Spicy Top Note Fragrance Ingredient
S-Methyl thioacetate
CAS 1534-08-03
What Is S-Methyl thioacetate?
S-Methyl thioacetate is a synthetic sulfur compound used in fragrance formulations. It’s found in trace amounts in some foods and is primarily encountered in perfumery. This ingredient matters because it provides a distinctive sulfurous character that can enhance savory or tropical fruit accords at very low concentrations.
Safety Profile
USE WITH AWARENESSWhat Does S-Methyl thioacetate Smell Like?
S-Methyl thioacetate delivers an intensely sulfurous, garlic-like punch at full strength that evolves into a tropical fruit nuance when highly diluted. The initial blast is reminiscent of crushed garlic cloves with metallic undertones, quickly transitioning to a sweeter, more rounded character resembling passionfruit or guava. The dry-down leaves a faintly savory, almost meaty impression that works exceptionally well in trace amounts to add complexity to fruity or gourmand compositions.
In Famous Fragrances
Fragrance associations may not reflect actual formulations.
Used in minute quantities to contribute to the mysterious, slightly animalic tropical fruit accord that defines this iconic fragrance.
Provides a savory edge to the gourmand chocolate-coffee accord, enhancing the fragrance’s distinctive character.
Chemistry, Properties & Perfumer Guide
The Chemistry
S-Methyl thioacetate belongs to the thioester class of organosulfur compounds. While it occurs naturally in trace amounts in some foods like garlic and passionfruit, commercial production typically involves the reaction of thioacetic acid with methanol in the presence of acid catalysts. The molecule’s sulfur-carbon bond contributes to its potent odor characteristics and reactivity.
Physical & Chemical Properties
| Boiling Point | Not well documented |
|---|---|
| Density | Not well documented |
Perfumer Guide
| Application | Typical % | Range | Notes |
|---|---|---|---|
| Fine Fragrance | 0.01-0.1% | Up to 0.5% | Used in trace amounts for effect |
| Functional Fragrance | 0.001-0.01% | Up to 0.05% | Very low levels for savory notes |
Classic Accords
Tip: Always pre-dilute to 1% or lower before incorporating into blends due to extreme potency.
Alternatives & Comparisons
Similar sulfurous character but slightly sweeter and less aggressive, useful when a softer effect is desired.
Safety, Regulatory & Sustainability
⚠ Regulatory Disclaimer
General reference only. Consult current IFRA Standards Library before formulating.
IFRA Status
No specific IFRA restrictions, but recommended for use at low levels due to potency.
GHS Classification
RIFM Assessment
Not currently evaluated by RIFM. Use caution based on structural analogs.
Sustainability
As a synthetic material produced in small quantities, S-Methyl thioacetate has minimal environmental impact. Production requires standard chemical safety protocols due to sulfur content.
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References
- Burdock, G.A. (2010). Fenaroli’s Handbook of Flavor Ingredients. CRC Press. ISBN 9781420090869
Data: PubChem (NIH), PubMed, RIFM, IFRA. Last reviewed: Apr 2026.
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