Thiazole (CAS 288-47-1) — Top Note Fragrance Ingredient

ByThe Good Scents



gourmand

Thiazole

CAS 288-47-1

Note
top
Volatility
high
MW
85.12
Data as of: Jun 2026

What Is Thiazole?

Thiazole (CAS 288-47-1) is an aroma chemical used as a fragrance and flavour ingredient. Its odour is described as bakery, sweet and fish, placing it within the gourmand family as a top note with high volatility. With a molecular weight of 85.12 (formula C3H3NS), it is handled by perfumers as a building block for compositions where a bakery character is desired. The data below is compiled from public chemical and regulatory sources.

Safety Profile

HANDLE WITH CARE

Generally safeUse with awarenessProfessional use
CAS
288-47-1
Formula
C3H3NS
MW
85.12
InChIKey
FZWLAAWBMGSTSO-UHFFFAOYSA-N
Thiazole 2D structure

Thiazole
C3H3NS
Layer 1 · Enthusiast

What Does Thiazole Smell Like?

The odour profile of Thiazole is reported as bakery, sweet, fish, garlic, spices, cold, sour, burnt, acid, musky, sweaty, ammonia/urinous, decayed, wood, grass, flower, chemical, edible. The dominant facet is its bakery character, with the remaining notes adding nuance and complexity. As a top note it contributes to the opening of a fragrance. Perceived intensity and exact character depend on concentration, the carrier and the surrounding accord.

Scent Profile

Profile derived from public odour-descriptor data; relative, not absolute.

Layer 2

Chemistry & Properties

The Chemistry

Thiazole has the molecular formula C3H3NS and a molecular weight of 85.12 g/mol. Its canonical SMILES representation is S1C=CN=C1. Its reported log P (XLogP) of 0.44 indicates a moderately polar molecule, which informs how it partitions in a formula. Physical constants below are drawn from PubChem and EPA CompTox public datasets.

Physical & Chemical Properties

Molecular Weight 85.12 g/mol
Boiling Point 116.5 °C
Melting Point -33.00 °C
Flash Point 25.55 °C
Density 1.20 g/cm³
Vapor Pressure 21.61 mmHg
Water Solubility 0.21 g/L
XLogP 0.44

Perfumer Guide

Note Position
Top
Volatility
High
Primary Odour
Bakery

Alternatives & Comparisons

Ingredients occupying a similar odour space — useful as substitutes or companions when Thiazole is unavailable or restricted.

1
Isopentylamine CAS 107-85-7

Shares bakery, sweet, fish character — a candidate substitute or companion in the same odour space.

2
2-Acetyl-3-Ethylpyrazine CAS 32974-92-8

Shares bakery, sweet, fish character — a candidate substitute or companion in the same odour space.

3
Ethyl 3-(Furfurylthio) Propionate CAS 94278-27-0

Shares bakery, sweet, fish character — a candidate substitute or companion in the same odour space.

Layer 3

Safety & Regulatory

⚠ Regulatory Disclaimer

General reference only. IFRA, REACH and EU Cosmetics Regulation standards update periodically. Consult the current IFRA Standards Library before formulating. Not legal or regulatory advice.

IFRA Status

No IFRA restriction recorded in the data set. This is not a guarantee of unrestricted status — always confirm against the current IFRA Standards Library.

GHS Classification

Signal word: Danger

H225H302
Formulating with Thiazole?

Open Thiazole in Fragrance Studio (Pro) for the calibrated vapour-pressure curve, the modelled odour-threshold estimate, and the substitute-matching engine across 2,900+ aromachemicals.

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References & Sources

  1. PubChem Compound Summary (NIH) — search by InChIKey
  2. EPA CompTox Chemicals Dashboard — physicochemical & fate data
  3. IFRA Standards Library (49th / 51st Amendment)
Sources: PubChem (NIH) · EPA CompTox · IFRA Standards Library · public GHS classification. Odour descriptors are original editorial summaries of public profiles, not reproduced from any single proprietary source.

Data: PubChem (NIH), EPA CompTox, IFRA. Last reviewed: Jun 2026.

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