1-(1,2,3,5,6,7,8,8a-Octahydro-2,3,8,8-tetramethyl-2-naphthyl)ethan-1-one (CAS 68155-66-8) — Musky Base Note Fragrance Ingredient
1-(1,2,3,5,6,7,8,8a-Octahydro-2,3,8,8-tetramethyl-2-naphthyl)ethan-1-one
CAS 68155-66-8
What Is 1-(1,2,3,5,6,7,8,8a-Octahydro-2,3,8,8-tetramethyl-2-naphthyl)ethan-1-one?
This synthetic musk compound is used as a long-lasting base note in modern perfumery. Found in laundry detergents, fabric softeners, and premium fragrances, it provides a clean, powdery character. As a cost-effective alternative to natural musks, it plays a crucial role in making everyday products smell pleasant while maintaining affordability.
Safety Profile
GENERALLY SAFEWhat Does 1-(1,2,3,5,6,7,8,8a-Octahydro-2,3,8,8-tetramethyl-2-naphthyl)ethan-1-one Smell Like?
This musk presents a soft, powdery aura with subtle laundry-fresh undertones. Imagine sun-dried linen infused with the faintest whisper of baby powder – not sweet, but comforting. Over hours, it evolves into a skin-like warmth, blending seamlessly with body chemistry. The dry-down is remarkably persistent, leaving a barely-there impression of cleanliness that lingers for days on fabrics.
In Famous Fragrances
Fragrance associations may not reflect actual formulations.
Used here to create the illusion of sun-baked laundry, blending with synthetic aldehydes for a fabric-softener freshness that lasts through multiple washes.
Provides the molecular backbone for this ‘skin-but-better’ scent, adding lasting power to the ambroxan and iris accord without overpowering.
2D Molecular Structure
SMILES: CC1C=C2CCCC(C)(C)C2CC1(C)C(C)=O
Chemistry, Properties & Perfumer Guide
The Chemistry
A synthetic polycyclic musk belonging to the tetralin class. Developed as an alternative to nitro musks, it features a complex hydrogenated naphthalene structure. Industrially produced via Friedel-Crafts acylation followed by hydrogenation. The rigid tetracyclic framework contributes to exceptional stability and longevity in formulations. Unlike macrocyclic musks, this compound is achiral and manufactured as a single isomer.
Physical & Chemical Properties
| Boiling Point | N/A |
|---|---|
| Density | N/A |
Perfumer Guide
| Application | Typical % | Range | Notes |
|---|---|---|---|
| Laundry Care | 0.1-0.5% | Up to 1% | Provides lasting freshness |
| Fine Fragrance | 0.5-2% | Up to 3% | Musky foundation |
Classic Accords
Tip: Use with white musks to create diffusion without overwhelming sweetness.
Alternatives & Comparisons
Safety, Regulatory & Sustainability
⚠ Regulatory Disclaimer
General reference only. Consult current IFRA Standards Library before formulating.
IFRA Status
Not currently restricted by IFRA.
EU Allergen Declaration
Not listed as an EU allergen.
RIFM Assessment
RIFM assessment confirms safe use at current industry levels.
Sustainability
As a purely synthetic material, production avoids wildlife impacts associated with natural musk harvesting. However, the petroleum-based synthesis raises carbon footprint concerns. Recent advances in catalytic hydrogenation have improved energy efficiency. Not known to bioaccumulate significantly.
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References
Data: PubChem (NIH), PubMed, RIFM, IFRA. Last reviewed: Apr 2026.
Report a data errorPhysicochemical Properties
DTXSID: DTXSID9052397
Physical Properties
| Molecular Weight | 234.383 g/mol🔬 EPA CompTox |
| Density | 0.944 g/cm^3📊 OPERA |
| Boiling Point | 294.939 °C📊 OPERA |
| Melting Point | 40.902 °C📊 OPERA |
| Flash Point | 135.024 °C📊 OPERA |
| Refractive Index | 1.493 Dimensionless📊 OPERA |
| Molar Volume | 247.089 cm^3/mol📊 OPERA |
Partition & Solubility
| LogP (Octanol-Water) | 4.571 Log10 unitless📊 OPERA |
| LogD (pH 5.5) | 4.571 Log10 unitless📊 OPERA |
| LogD (pH 7.4) | 4.571 Log10 unitless📊 OPERA |
| LogKoa (Octanol-Air) | 7.51 Log10 unitless📊 OPERA |
| Water Solubility | 0 mol/L📊 OPERA |
| Henry's Law Constant | 0 atm-m3/mole📊 OPERA |
Transport Properties
| Vapor Pressure | 0.001 mmHg📊 OPERA |
| Surface Tension | 32.09 dyn/cm📊 OPERA |
| Thermal Conductivity | 115.592 mW/(m*K)📊 OPERA |
Molecular Descriptors
| Topological Polar Surface Area | 17.07 Ų💻 Computed |
| H-Bond Donors | 0 count💻 Computed |
| H-Bond Acceptors | 1 count💻 Computed |
| Rotatable Bonds | 1 count💻 Computed |
| Aromatic Rings | 0 count💻 Computed |
| Molar Refractivity | 71.809 cm^3/mol📊 OPERA |
| Polarizability | 28.467 Å^3📊 OPERA |
Data Sources:
🔬 EPA Experimental data from U.S. EPA CompTox Chemicals Dashboard & CTX APIs. 📊 OPERA Predicted using EPA's OPERA QSAR models. 💻 Computed Calculated from SMILES using RDKit.
