1,1-Dihexyloxyhexane (CAS 33673-65-3) — Woody Base Note Fragrance Ingredient
1,1-Dihexyloxyhexane
CAS 33673-65-3
What Is 1,1-Dihexyloxyhexane?
1,1-Dihexyloxyhexane is a synthetic compound used in fragrance formulations. It contributes to the overall scent profile of perfumes and personal care products. This ingredient is valued for its ability to enhance longevity and blend well with other fragrance components, making it a versatile tool for perfumers.
Safety Profile
GENERALLY SAFEWhat Does 1,1-Dihexyloxyhexane Smell Like?
1,1-Dihexyloxyhexane has a subtle, clean, and slightly waxy odor. It evolves from a faintly sweet top note to a more neutral, long-lasting base. Its dry-down is smooth and unobtrusive, making it an excellent carrier for more volatile fragrance ingredients.
In Famous Fragrances
Fragrance associations may not reflect actual formulations.
Used as a base stabilizer to enhance the longevity of citrus top notes without altering their character.
2D Molecular Structure
SMILES: CCCCCCOC(CCCCC)OCCCCCC
Chemistry, Properties & Perfumer Guide
The Chemistry
1,1-Dihexyloxyhexane is a synthetic ether compound. It is produced through the etherification of hexanol. Its structure provides stability and longevity in fragrance formulations. The compound is non-reactive and blends well with a variety of scent profiles.
Physical & Chemical Properties
| Boiling Point | N/A |
|---|---|
| Density | N/A |
Perfumer Guide
| Application | Typical % | Range | Notes |
|---|---|---|---|
| Fine Fragrance | 1-5% | Up to 10% | Enhances longevity |
| Personal Care | 0.5-3% | Up to 5% | Stabilizes fragrance |
Classic Accords
Tip: Use as a base stabilizer to extend the life of more volatile top notes.
Alternatives & Comparisons
A common solvent and fixative with similar stabilizing properties.
Safety, Regulatory & Sustainability
⚠ Regulatory Disclaimer
General reference only. Consult current IFRA Standards Library before formulating.
IFRA Status
No restrictions under IFRA standards.
EU Allergen Declaration
Not listed as an EU allergen.
RIFM Assessment
No specific RIFM assessment found.
Sustainability
Synthetic production ensures consistent quality and reduces reliance on natural resources. The environmental impact is minimal due to controlled manufacturing processes.
Explore 1,1-Dihexyloxyhexane
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References
- PubChem Compound Summary for 1,1-Dihexyloxyhexane PubChem
Data: PubChem (NIH), PubMed, RIFM, IFRA. Last reviewed: Apr 2026.
Report a data errorIngredient Data Sheet
CAS 33673-65-3Physical Properties
| Molecular Weight | 286.5 g/mol🔬 PubChem |
| LogP (Octanol-Water) | 7.1🔬 PubChem |
| Boiling Point | 332 °C🔬 EPA CompTox |
| Vapor Pressure | 0.0001 mmHg @ 25°C📊 OPERA |
| Flash Point | 49.6 °C🔬 EPA CompTox |
| log Kp (skin permeability) | 0.593💻 Calculated |
| SMILES | CCCCCCOC(CCCCC)OCCCCCC🔬 PubChem |
Volatility & Performance
| Fragrance Note | Base💻 Calculated |
| Volatility Class | Very slow💻 Calculated |
| Persistence Score | 13.8 / 5💻 Calculated |
Odor & Flavor
| Primary Descriptors | applegrassygreen• leffingwell |
| Functional Groups | ether💻 RDKit |
Physical data: PubChem (NIH/NLM), U.S. EPA CompTox Dashboard, EPA OPERA models, RDKit. Odor & flavor: Arctander (Perfume & Flavor Chemicals), Fenaroli's Handbook of Flavor Ingredients, Leffingwell. Thresholds: van Gemert (Compilations of Odour Threshold Values). Regulatory: IFRA Standards 51st, FEMA GRAS. Trade names: Surburg (Common Fragrance & Flavor Materials). All data compiled and cross-referenced for perfumertools.com.
Physicochemical Properties
DTXSID: DTXSID30187353
Physical Properties
| Molecular Weight | 286.5 g/mol🔬 EPA CompTox |
| Density | 0.841 g/cm^3🔬 EPA CTX |
| Boiling Point | 303.676 °C📊 OPERA |
| Melting Point | -21.505 °C📊 OPERA |
| Flash Point | 85.181 °C📊 OPERA |
| Refractive Index | 1.438 Dimensionless📊 OPERA |
| Molar Volume | 338.758 cm^3/mol📊 OPERA |
Partition & Solubility
| LogP (Octanol-Water) | 7.239 Log10 unitless📊 OPERA |
| LogD (pH 5.5) | 7.239 Log10 unitless📊 OPERA |
| LogD (pH 7.4) | 7.239 Log10 unitless📊 OPERA |
| LogKoa (Octanol-Air) | 8.96 Log10 unitless📊 OPERA |
| Water Solubility | 0 mol/L📊 OPERA |
| Henry's Law Constant | 0 atm-m3/mole📊 OPERA |
Transport Properties
| Vapor Pressure | 0.005 mmHg📊 OPERA |
| Viscosity | 6.391 cP📊 OPERA |
| Surface Tension | 27.731 dyn/cm📊 OPERA |
| Thermal Conductivity | 142.41 mW/(m*K)📊 OPERA |
Molecular Descriptors
| Topological Polar Surface Area | 18.46 Ų💻 Computed |
| H-Bond Donors | 0 count💻 Computed |
| H-Bond Acceptors | 2 count💻 Computed |
| Rotatable Bonds | 16 count💻 Computed |
| Aromatic Rings | 0 count💻 Computed |
| Molar Refractivity | 88.89 cm^3/mol📊 OPERA |
| Polarizability | 35.239 Å^3📊 OPERA |
Data Sources:
🔬 EPA Experimental data from U.S. EPA CompTox Chemicals Dashboard & CTX APIs. 📊 OPERA Predicted using EPA's OPERA QSAR models. 💻 Computed Calculated from SMILES using RDKit.
