1,1-Dimethoxycyclododecane (CAS 950-33-4) — Woody Base Note Fragrance Ingredient

ByThe Good Scents
Woody · Musky

1,1-Dimethoxycyclododecane

CAS 950-33-4

Origin
synthetic
Note
Base
IFRA
Generally safe
Data as of: Apr 2026

What Is 1,1-Dimethoxycyclododecane?

1,1-Dimethoxycyclododecane is a synthetic fragrance ingredient used in perfumes and scented products. It contributes to complex woody and musky accords. This molecule helps create long-lasting fragrance foundations in premium perfumery.

Safety Profile

GENERALLY SAFE
Generally safeUse with awarenessProfessional use
✓ No major safety concerns
⚠ Limited toxicological data available
CAS
950-33-4
Formula
Mixture
MW
Variable
Odor Family
Woody · Musky
Layer 1 · Enthusiast

What Does 1,1-Dimethoxycyclododecane Smell Like?

1,1-Dimethoxycyclododecane presents a subtle woody-musky character with faint floral undertones. The double methoxy groups lend an ethereal, slightly ozonic quality that evolves into a clean muskiness over time. It behaves like a molecular whisper – not dominant but essential for rounding out harsh edges in woody compositions. The dry-down reveals a soft, skin-like warmth reminiscent of well-aged paper.

Scent Profile
Layer 2

2D Molecular Structure

1,1-Dimethoxycyclododecane

SMILES: COC1(CCCCCCCCCCC1)OC

Chemistry, Properties & Perfumer Guide

The Chemistry

1,1-Dimethoxycyclododecane belongs to the class of cyclic acetals, specifically a cyclododecane derivative with two methoxy groups at the 1-position. It is produced through acid-catalyzed reactions of cyclododecanone with methanol. The molecule’s twelve-membered ring structure provides conformational flexibility that influences its diffusion properties. While not chiral itself, it can exist in multiple conformational states that affect odor perception.

Physical & Chemical Properties

Perfumer Guide

Note Position
Base
Volatility
Very low (8+ hours)
Blending
Good
ApplicationTypical %RangeNotes
Fine Fragrance0.5-2%Up to 5%Background musk enhancer
Functional Fragrance0.1-0.5%Up to 1%Soap and detergent base

Classic Accords

Tip: Use as a transparent musk modifier in woody-amber bases to add diffusion without heaviness.

Alternatives & Comparisons

1
Cyclododecanone CAS 830-13-7

The precursor ketone offers similar woody aspects but lacks the muskiness and stability of the acetal.

2
Ethylene Brassylate CAS 105-95-3

For stronger musk effects while maintaining good stability in alkaline systems.

Layer 3

Safety, Regulatory & Sustainability

⚠ Regulatory Disclaimer

General reference only. Consult current IFRA Standards Library before formulating.

IFRA Status

Not currently restricted by IFRA standards.

RIFM Assessment

No RIFM assessment publicly available as of 2023.

Sustainability

As a fully synthetic material, 1,1-Dimethoxycyclododecane avoids natural resource depletion concerns. Its production involves petrochemical feedstocks but requires relatively mild conditions compared to many fragrance synthetics. The molecule’s stability contributes to longer-lasting fragrances, potentially reducing reapplication frequency.

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References

    Data: PubChem (NIH), PubMed, RIFM, IFRA. Last reviewed: Apr 2026.

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    Ingredient Data Sheet

    CAS 950-33-4

    Physical Properties

    Molecular Weight228.37 g/mol🔬 PubChem
    LogP (Octanol-Water)4.9🔬 PubChem
    Boiling Point273 °C🔬 EPA CompTox
    Vapor Pressure0.12 mmHg @ 25°C📊 OPERA
    Flash Point124 °C🔬 EPA CompTox
    Involatility Index0.0086💻 Calculated
    log Kp (skin permeability)-0.614💻 Calculated
    SMILESCOC1(CCCCCCCCCCC1)OC🔬 PubChem

    Volatility & Performance

    Fragrance NoteHeart💻 Calculated
    Volatility ClassVery slow💻 Calculated
    Persistence Score2.2 / 5💻 Calculated

    Odor & Flavor

    Functional Groupsether💻 RDKit
    Data Sources & Attribution
    Physical data: PubChem (NIH/NLM), U.S. EPA CompTox Dashboard, EPA OPERA models, RDKit. Odor & flavor: Arctander (Perfume & Flavor Chemicals), Fenaroli's Handbook of Flavor Ingredients, Leffingwell. Thresholds: van Gemert (Compilations of Odour Threshold Values). Regulatory: IFRA Standards 51st, FEMA GRAS. Trade names: Surburg (Common Fragrance & Flavor Materials). All data compiled and cross-referenced for perfumertools.com.

    Physicochemical Properties

    DTXSID: DTXSID4052639

    Physical Properties

    Molecular Weight 228.376 g/mol🔬 EPA CompTox
    Density 0.96 g/cm^3🔬 EPA CTX
    Boiling Point 273 °C🔬 EPA CTX
    Melting Point 6.9 °C🔬 EPA CTX
    Flash Point 124 °C🔬 EPA CTX
    Refractive Index 1.451 Dimensionless📊 OPERA
    Molar Volume 253.803 cm^3/mol📊 OPERA

    Partition & Solubility

    LogP (Octanol-Water) 4.65 Log10 unitless🔬 EPA CTX
    LogD (pH 5.5) 5.126 Log10 unitless📊 OPERA
    LogD (pH 7.4) 5.126 Log10 unitless📊 OPERA
    LogKoa (Octanol-Air) 7.56 Log10 unitless📊 OPERA
    Water Solubility 0 mol/L🔬 EPA CTX
    Henry's Law Constant 0.001 atm-m3/mole📊 OPERA

    Transport Properties

    Vapor Pressure 0.139 mmHg🔬 EPA CTX
    Viscosity 5.628 cP📊 OPERA
    Surface Tension 30.452 dyn/cm📊 OPERA
    Thermal Conductivity 139.36 mW/(m*K)📊 OPERA

    Molecular Descriptors

    Topological Polar Surface Area 18.46 Ų💻 Computed
    H-Bond Donors 0 count💻 Computed
    H-Bond Acceptors 2 count💻 Computed
    Rotatable Bonds 2 count💻 Computed
    Aromatic Rings 0 count💻 Computed
    Molar Refractivity 68.316 cm^3/mol📊 OPERA
    Polarizability 27.083 Å^3📊 OPERA

    Data Sources:

    🔬 EPA Experimental data from U.S. EPA CompTox Chemicals Dashboard & CTX APIs. 📊 OPERA Predicted using EPA's OPERA QSAR models. 💻 Computed Calculated from SMILES using RDKit.

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