(1-Ethoxyethoxy)-cyclododecane (CAS 389083-83-4) — Woody Base Note Fragrance Ingredient

ByThe Good Scents
Woody · Balsamic

(1-Ethoxyethoxy)-cyclododecane

CAS 389083-83-4

Origin
synthetic
Note
Base
IFRA
Use with awareness
Data as of: Apr 2026

What Is (1-Ethoxyethoxy)-cyclododecane?

(1-Ethoxyethoxy)-cyclododecane is a synthetic fragrance ingredient used in modern perfumery to create unique, long-lasting scents. It’s found in some niche and experimental fragrances. This compound matters because it offers perfumers a novel way to build complexity and longevity in fragrance compositions, especially in woody or musky accords where traditional ingredients may be limited.

Safety Profile

USE WITH AWARENESS
Generally safeUse with awarenessProfessional use
✓ No major safety concerns reported
⚠ Limited safety data available
CAS
389083-83-4
Formula
Mixture
MW
Variable
Odor Family
Woody · Balsamic
Layer 1 · Enthusiast

What Does (1-Ethoxyethoxy)-cyclododecane Smell Like?

This synthetic molecule presents a sophisticated woody-amber character with subtle ether-like undertones. The initial impression is clean and slightly metallic, evolving into a warm, musky heart with a faintly sweet, almost vanillic nuance. The dry-down reveals a persistent woody base that blends exceptionally well with sandalwood and patchouli derivatives, creating a modern interpretation of classic woody accords.

Scent Profile
Layer 2

2D Molecular Structure

Cyclododecane, (1-ethoxyethoxy)-

SMILES: CCOC(C)OC1CCCCCCCCCCC1

Chemistry, Properties & Perfumer Guide

The Chemistry

(1-Ethoxyethoxy)-cyclododecane is a synthetic cyclic ether derivative with a dodecane backbone. The molecule features an ethoxyethoxy side chain that contributes to its unique odor profile and solubility characteristics. It’s typically synthesized through etherification reactions of cyclododecanol with ethylene oxide derivatives. The large ring structure provides excellent stability and longevity in fragrance applications.

Physical & Chemical Properties

Perfumer Guide

Note Position
Base
Volatility
Very low (12+ hours)
Blending
Good
ApplicationTypical %RangeNotes
Fine Fragrance0.5-2%Up to 5%Woody-amber base note
Functional Fragrance0.1-0.5%Up to 1%Longevity enhancer

Classic Accords

Tip: Use as a fixative in woody oriental compositions to enhance diffusion and longevity.

Alternatives & Comparisons

1
Ambroxan CAS 6790-58-5

More widely available woody-amber with similar performance characteristics.

2
Iso E Super CAS 54464-57-2

Provides complementary woody notes with better-known blending properties.

Layer 3

Safety, Regulatory & Sustainability

⚠ Regulatory Disclaimer

General reference only. Consult current IFRA Standards Library before formulating.

IFRA Status

No IFRA restrictions currently apply to this material.

RIFM Assessment

Safety assessment data not yet available from RIFM.

Sustainability

As a synthetic material, (1-Ethoxyethoxy)-cyclododecane offers consistent quality and avoids natural resource depletion. However, its environmental impact during synthesis should be considered. The compound’s persistence in the environment has not been fully characterized, warranting careful formulation practices.

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References

    Data: PubChem (NIH), PubMed, RIFM, IFRA. Last reviewed: Apr 2026.

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    Ingredient Data Sheet

    CAS 389083-83-4

    Physical Properties

    Molecular Weight256.42 g/mol🔬 PubChem
    LogP (Octanol-Water)5.9🔬 PubChem
    Boiling Point303 °C🔬 EPA CompTox
    Vapor Pressure0.0001 mmHg @ 25°C📊 OPERA
    Flash Point79.9 °C🔬 EPA CompTox
    log Kp (skin permeability)-0.075💻 Calculated
    SMILESCCOC(C)OC1CCCCCCCCCCC1🔬 PubChem

    Volatility & Performance

    Fragrance NoteBase💻 Calculated
    Volatility ClassVery slow💻 Calculated
    Persistence Score11.9 / 5💻 Calculated

    Odor & Flavor

    Functional Groupsether💻 RDKit
    Data Sources & Attribution
    Physical data: PubChem (NIH/NLM), U.S. EPA CompTox Dashboard, EPA OPERA models, RDKit. Odor & flavor: Arctander (Perfume & Flavor Chemicals), Fenaroli's Handbook of Flavor Ingredients, Leffingwell. Thresholds: van Gemert (Compilations of Odour Threshold Values). Regulatory: IFRA Standards 51st, FEMA GRAS. Trade names: Surburg (Common Fragrance & Flavor Materials). All data compiled and cross-referenced for perfumertools.com.

    Physicochemical Properties

    DTXSID: DTXSID00889019

    Physical Properties

    Molecular Weight 256.43 g/mol🔬 EPA CompTox
    Density 0.876 g/cm^3📊 OPERA
    Boiling Point 300.642 °C📊 OPERA
    Melting Point -4.289 °C📊 OPERA
    Flash Point 102.737 °C📊 OPERA
    Refractive Index 1.452 Dimensionless📊 OPERA
    Molar Volume 287.242 cm^3/mol📊 OPERA

    Partition & Solubility

    LogP (Octanol-Water) 5.902 Log10 unitless📊 OPERA
    LogD (pH 5.5) 5.902 Log10 unitless📊 OPERA
    LogD (pH 7.4) 5.902 Log10 unitless📊 OPERA
    LogKoa (Octanol-Air) 8.41 Log10 unitless📊 OPERA
    Water Solubility 0 mol/L📊 OPERA
    Henry's Law Constant 0 atm-m3/mole📊 OPERA

    Transport Properties

    Vapor Pressure 0.002 mmHg📊 OPERA
    Viscosity 6.403 cP📊 OPERA
    Surface Tension 30.776 dyn/cm📊 OPERA
    Thermal Conductivity 141.063 mW/(m*K)📊 OPERA

    Molecular Descriptors

    Topological Polar Surface Area 18.46 Ų💻 Computed
    H-Bond Donors 0 count💻 Computed
    H-Bond Acceptors 2 count💻 Computed
    Rotatable Bonds 4 count💻 Computed
    Aromatic Rings 0 count💻 Computed
    Molar Refractivity 77.525 cm^3/mol📊 OPERA
    Polarizability 30.733 Å^3📊 OPERA

    Data Sources:

    🔬 EPA Experimental data from U.S. EPA CompTox Chemicals Dashboard & CTX APIs. 📊 OPERA Predicted using EPA's OPERA QSAR models. 💻 Computed Calculated from SMILES using RDKit.

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