(-)-epi–Bisabolol (CAS 78148-59-1) — Floral Middle Note Fragrance Ingredient
(-)-epi-_-Bisabolol
CAS 78148-59-1
What Is (-)-epi-_-Bisabolol?
(-)-epi-α-Bisabolol is a naturally occurring sesquiterpene alcohol, primarily found in chamomile essential oil. It’s commonly used in skincare products for its soothing properties and in fragrances for its delicate floral-woody scent. This ingredient matters because it offers both functional benefits and a subtle, elegant aroma profile that enhances personal care formulations without overwhelming other notes.
Safety Profile
GENERALLY SAFEWhat Does (-)-epi-_-Bisabolol Smell Like?
(-)-epi-α-Bisabolol presents a soft, elegant aroma blending delicate floral tones with creamy woodiness. Its scent evolves from an initial whisper of chamomile tea to a heart of powdery sweetness reminiscent of fine baby powder, settling into a warm, slightly balsamic dry-down. The overall effect is gentle yet persistent, like sunlight filtering through linen curtains in a room with polished wooden floors.
Chemistry, Properties & Perfumer Guide
The Chemistry
(-)-epi-α-Bisabolol is a monocyclic sesquiterpene alcohol with three chiral centers, making stereochemistry particularly important for its odor profile. While naturally occurring in chamomile (Matricaria chamomilla), most commercial material is produced synthetically via hydrogenation of bisabolol oxides. The (-)-epi stereoisomer demonstrates superior olfactory properties compared to other forms, with a more refined floral character and better stability in formulations.
Physical & Chemical Properties
| Appearance | Colorless to pale yellow viscous liquid |
|---|---|
| Solubility | Soluble in alcohol, oils; insoluble in water |
Perfumer Guide
| Application | Typical % | Range | Notes |
|---|---|---|---|
| Fine Fragrance | 0.5-2% | Up to 5% | Adds soft floral-woody nuance |
| Skincare Fragrance | 1-3% | Up to 5% | Functional soothing properties |
| Home Fragrance | 0.1-1% | Up to 2% | Subtle background note |
Classic Accords
Tip: Use to soften harsh top notes and add skin-compatible warmth to floral compositions.
Alternatives & Comparisons
The racemic form with similar properties but less refined odor profile, often used when cost is a primary concern.
Oxidized form found naturally in chamomile, with sharper herbal character but less stability in formulations.
Safety, Regulatory & Sustainability
⚠ Regulatory Disclaimer
General reference only. Consult current IFRA Standards Library before formulating.
IFRA Status
Not restricted by IFRA – no usage limits apply.
RIFM Assessment
RIFM has assessed α-Bisabolol and related compounds as safe for current fragrance use levels.
Sustainability
While naturally derived from chamomile, most (-)-epi-α-Bisabolol is produced synthetically to meet demand and ensure consistent quality. The synthetic production route reduces agricultural land use compared to natural extraction. Green chemistry approaches are being developed to improve the sustainability of bisabolol production processes.
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