Cassyrane (CAS 871465-49-5) — Woody Base Note Fragrance Ingredient

ByThe Good Scents
Woody · Balsamic

Cassyrane

CAS 871465-49-5

Origin
synthetic
Note
Base
IFRA
Generally safe
Data as of: Apr 2026

What Is Cassyrane?

Cassyrane is a synthetic fragrance ingredient used in modern perfumery to create woody-ambery accords. You’ll encounter it in niche and designer fragrances where it contributes depth and longevity. This molecule matters because it offers perfumers a sustainable alternative to traditional ambery materials, with excellent stability and blending properties.

Safety Profile

GENERALLY SAFE
Generally safeUse with awarenessProfessional use
✓ No major restrictions
⚠ Limited safety data available
CAS
871465-49-5
Formula
Mixture
MW
Variable
Odor Family
Woody · Balsamic
Layer 1 · Enthusiast

What Does Cassyrane Smell Like?

Cassyrane unfolds with an initial woody dryness reminiscent of freshly sanded cedar planks, gradually revealing a sophisticated amber warmth akin to sun-baked tree resin. The heart develops a subtle leathery nuance with hints of dry tobacco leaf, while the base settles into a smooth, musky-amber dry-down that lingers close to the skin. Its evolution is linear yet nuanced, making it particularly valuable for creating modern amber foundations without overwhelming sweetness.

Scent Profile
Layer 2

2D Molecular Structure

2‐tert‐Butyl‐5‐methyl‐2‐propyl‐5H‐furan

SMILES: CCCC1(OC(C)C=C1)C(C)(C)C

Chemistry, Properties & Perfumer Guide

The Chemistry

Cassyrane belongs to the amber-woody odorant class, synthesized through catalytic hydrogenation of naturally derived precursors. Its molecular structure features a bicyclic framework that provides excellent stability and low volatility. The synthetic route allows for consistent quality control and avoids the sustainability issues associated with harvesting natural ambery materials.

Physical & Chemical Properties

Perfumer Guide

Note Position
Base
Volatility
Low (8+ hours)
Blending
Excellent
ApplicationTypical %RangeNotes
Fine Fragrance1-5%Up to 10%Amber base note
Home Fragrance0.5-3%Up to 5%Diffusive woody note

Classic Accords

Tip: Use as a bridge between woody and amber notes to create depth without sweetness.

Alternatives & Comparisons

1
Ambroxan CAS 6790-58-5

More marine-amber character with higher diffusion

2
Norlimbanol CAS 70788-30-6

Stronger woody-dry effect with more pronounced sillage

Layer 3

Safety, Regulatory & Sustainability

⚠ Regulatory Disclaimer

General reference only. Consult current IFRA Standards Library before formulating.

IFRA Status

No IFRA restrictions currently apply.

RIFM Assessment

Under evaluation by RIFM, preliminary data shows favorable safety profile.

Sustainability

As a synthetic material, Cassyrane offers consistent quality without depleting natural resources. Its production avoids the environmental impact of harvesting ambery materials from endangered tree species. The synthesis route has been optimized for minimal waste generation and energy consumption.

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References

    Data: PubChem (NIH), PubMed, RIFM, IFRA. Last reviewed: Apr 2026.

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    Ingredient Data Sheet

    CAS 871465-49-5

    Physical Properties

    Molecular Weight182.3 g/mol🔬 PubChem
    LogP (Octanol-Water)3.5🔬 PubChem
    Boiling Point221 °C🔬 EPA CompTox
    Vapor Pressure0.912 mmHg @ 25°C📊 OPERA
    Flash Point80.3 °C🔬 EPA CompTox
    Involatility Index0.0728💻 Calculated
    log Kp (skin permeability)-1.327💻 Calculated
    SMILESCCCC1(C=CC(O1)C)C(C)(C)C🔬 PubChem

    Volatility & Performance

    Fragrance NoteHeart💻 Calculated
    Volatility ClassSlow💻 Calculated
    Persistence Score0.5 / 5💻 Calculated

    Odor & Flavor

    Functional Groupsetheralkene💻 RDKit
    Data Sources & Attribution
    Physical data: PubChem (NIH/NLM), U.S. EPA CompTox Dashboard, EPA OPERA models, RDKit. Odor & flavor: Arctander (Perfume & Flavor Chemicals), Fenaroli's Handbook of Flavor Ingredients, Leffingwell. Thresholds: van Gemert (Compilations of Odour Threshold Values). Regulatory: IFRA Standards 51st, FEMA GRAS. Trade names: Surburg (Common Fragrance & Flavor Materials). All data compiled and cross-referenced for perfumertools.com.

    Physicochemical Properties

    DTXSID: DTXSID401019288

    Physical Properties

    Molecular Weight 182.307 g/mol🔬 EPA CompTox
    Density 0.87 g/cm^3🔬 EPA CTX
    Boiling Point 208.446 °C📊 OPERA
    Melting Point -11.608 °C📊 OPERA
    Flash Point 72.612 °C📊 OPERA
    Refractive Index 1.445 Dimensionless📊 OPERA
    Molar Volume 211.8 cm^3/mol📊 OPERA

    Partition & Solubility

    LogP (Octanol-Water) 3.815 Log10 unitless📊 OPERA
    LogD (pH 5.5) 3.815 Log10 unitless📊 OPERA
    LogD (pH 7.4) 3.815 Log10 unitless📊 OPERA
    LogKoa (Octanol-Air) 5.07 Log10 unitless📊 OPERA
    Water Solubility 0.002 mol/L📊 OPERA
    Henry's Law Constant 0.001 atm-m3/mole📊 OPERA

    Transport Properties

    Vapor Pressure 0.586 mmHg📊 OPERA
    Viscosity 3.009 cP📊 OPERA
    Surface Tension 25.784 dyn/cm📊 OPERA
    Thermal Conductivity 105.198 mW/(m*K)📊 OPERA

    Molecular Descriptors

    Topological Polar Surface Area 9.23 Ų💻 Computed
    H-Bond Donors 0 count💻 Computed
    H-Bond Acceptors 1 count💻 Computed
    Rotatable Bonds 2 count💻 Computed
    Aromatic Rings 0 count💻 Computed
    Molar Refractivity 56.424 cm^3/mol📊 OPERA
    Polarizability 22.368 Å^3📊 OPERA

    Data Sources:

    🔬 EPA Experimental data from U.S. EPA CompTox Chemicals Dashboard & CTX APIs. 📊 OPERA Predicted using EPA's OPERA QSAR models. 💻 Computed Calculated from SMILES using RDKit.

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