(1R)-Nopol (CAS 35836-73-8) — Woody Top to Middle Note Fragrance Ingredient
(1R)-Nopol
CAS 35836-73-8
What Is (1R)-Nopol?
(1R)-Nopol is a synthetic fragrance ingredient used in perfumes and household products for its fresh, woody-pine aroma. It’s commonly found in masculine fragrances, air fresheners, and cleaning products. This molecule matters because it provides a sustainable alternative to traditional pine-derived scents, offering consistent quality without relying on natural resources.
Safety Profile
GENERALLY SAFEWhat Does (1R)-Nopol Smell Like?
(1R)-Nopol delivers a crisp, woody-pine scent with a subtle citrus undertone. The aroma evolves from a bright, almost camphoraceous top note to a heart of clean woodiness, reminiscent of freshly cut pine branches. Dry-down reveals a faintly balsamic character that lingers close to the skin. The synthetic nature ensures a precise, consistent profile without the variability of natural pine extracts.
In Famous Fragrances
Fragrance associations may not reflect actual formulations.
Used to enhance the pine forest accord, providing a synthetic alternative to natural pine oils for consistent performance.
Contributes to the fresh woody opening, blending with lavender and citrus for a masculine fougère structure.
2D Molecular Structure
SMILES: [H][C@@]12C[C@@]([H])(C(CCO)=CC1)C2(C)C
Chemistry, Properties & Perfumer Guide
The Chemistry
(1R)-Nopol is a chiral monoterpenoid alcohol derived from β-pinene. Its synthesis typically involves the Prins reaction of β-pinene with formaldehyde. The (1R) enantiomer is preferred in perfumery for its superior odor characteristics. As a synthetic molecule, it offers consistent quality and sustainability advantages over natural pine oil extraction.
Physical & Chemical Properties
| Boiling Point | 198 °C |
|---|---|
| Density | 0.865 g/cm³ |
Perfumer Guide
| Application | Typical % | Range | Notes |
|---|---|---|---|
| Fine Fragrance | 1-3% | Up to 5% | Woody fresh modifier |
| Functional Products | 0.5-2% | Up to 3% | Clean pine note |
Classic Accords
Tip: Use in fougère compositions to enhance woody freshness without overpowering floral elements.
Alternatives & Comparisons
Safety, Regulatory & Sustainability
⚠ Regulatory Disclaimer
General reference only. Consult current IFRA Standards Library before formulating.
IFRA Status
No IFRA restrictions apply to (1R)-Nopol.
RIFM Assessment
RIFM has assessed (1R)-Nopol as safe for current use levels in fragrance applications.
Sustainability
As a synthetic material, (1R)-Nopol offers consistent quality without depleting natural pine resources. Its production from β-pinene, a byproduct of the paper industry, represents efficient utilization of existing materials. The process avoids the environmental impact of pine forest harvesting.
Explore (1R)-Nopol
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References
- PubChem: (1R)-Nopol CID 6436584
- Bauer et al. (2001). Common Fragrance and Flavor Materials.
Data: PubChem (NIH), PubMed, RIFM, IFRA. Last reviewed: Apr 2026.
Report a data errorIngredient Data Sheet
CAS 35836-73-8Physical Properties
| Molecular Weight | 166.26 g/mol🔬 PubChem |
| LogP (Octanol-Water) | 2.1🔬 PubChem |
| Boiling Point | 235 °C🔬 EPA CompTox |
| Vapor Pressure | 0.0156 mmHg @ 25°C📊 OPERA |
| Flash Point | 107 °C🔬 EPA CompTox |
| Involatility Index | 0.0013💻 Calculated |
| log Kp (skin permeability) | -2.223💻 Calculated |
| SMILES | CC1(C2CC=C(C1C2)CCO)C🔬 PubChem |
Volatility & Performance
| Fragrance Note | Heart💻 Calculated |
| Volatility Class | Very slow💻 Calculated |
| Persistence Score | 2.8 / 5💻 Calculated |
Odor & Flavor
| Functional Groups | alcoholalkene💻 RDKit |
| “Nopol is by and large confined to woody and piney fragrance types, in which it may be the chief ingredient or "carrier". But its own odor contribution is very limited, and the title material will ruin almost any floral note if the Nopol is used at higher levels of concentration.”📖 Arctander | |
Physical data: PubChem (NIH/NLM), U.S. EPA CompTox Dashboard, EPA OPERA models, RDKit. Odor & flavor: Arctander (Perfume & Flavor Chemicals), Fenaroli's Handbook of Flavor Ingredients, Leffingwell. Thresholds: van Gemert (Compilations of Odour Threshold Values). Regulatory: IFRA Standards 51st, FEMA GRAS. Trade names: Surburg (Common Fragrance & Flavor Materials). All data compiled and cross-referenced for perfumertools.com.
Physicochemical Properties
DTXSID: DTXSID601044956
Physical Properties
| Molecular Weight | 166.264 g/mol🔬 EPA CompTox |
| Density | 0.001 g/cm^3🔬 EPA CTX |
| Boiling Point | 235 °C🔬 EPA CTX |
| Melting Point | 50.077 °C📊 OPERA |
| Flash Point | 107 °C🔬 EPA CTX |
| Refractive Index | 1.501 Dimensionless📊 OPERA |
| Molar Volume | 169.991 cm^3/mol📊 OPERA |
Partition & Solubility
| LogP (Octanol-Water) | 3.09 Log10 unitless🔬 EPA CTX |
| LogD (pH 5.5) | 3.252 Log10 unitless📊 OPERA |
| LogD (pH 7.4) | 3.252 Log10 unitless📊 OPERA |
| LogKoa (Octanol-Air) | 7.71 Log10 unitless📊 OPERA |
| Water Solubility | 0.002 mol/L🔬 EPA CTX |
| Henry's Law Constant | 0 atm-m3/mole📊 OPERA |
Transport Properties
| Vapor Pressure | 0.024 mmHg🔬 EPA CTX |
| Viscosity | 15.212 cP📊 OPERA |
| Surface Tension | 31.705 dyn/cm📊 OPERA |
| Thermal Conductivity | 132.82 mW/(m*K)📊 OPERA |
Molecular Descriptors
| Topological Polar Surface Area | 20.23 Ų💻 Computed |
| H-Bond Donors | 1 count💻 Computed |
| H-Bond Acceptors | 1 count💻 Computed |
| Rotatable Bonds | 2 count💻 Computed |
| Aromatic Rings | 0 count💻 Computed |
| Molar Refractivity | 50.117 cm^3/mol📊 OPERA |
| Polarizability | 19.868 Å^3📊 OPERA |
Data Sources:
🔬 EPA Experimental data from U.S. EPA CompTox Chemicals Dashboard & CTX APIs. 📊 OPERA Predicted using EPA's OPERA QSAR models. 💻 Computed Calculated from SMILES using RDKit.
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