(1R)-Nopol (CAS 35836-73-8) — Woody Top to Middle Note Fragrance Ingredient
(1R)-Nopol
CAS 35836-73-8
What Is (1R)-Nopol?
(1R)-Nopol is a synthetic fragrance ingredient used in perfumes and household products for its fresh, woody-pine aroma. It’s commonly found in masculine fragrances, air fresheners, and cleaning products. This molecule matters because it provides a sustainable alternative to traditional pine-derived scents, offering consistent quality without relying on natural resources.
Safety Profile
GENERALLY SAFEWhat Does (1R)-Nopol Smell Like?
(1R)-Nopol delivers a crisp, woody-pine scent with a subtle citrus undertone. The aroma evolves from a bright, almost camphoraceous top note to a heart of clean woodiness, reminiscent of freshly cut pine branches. Dry-down reveals a faintly balsamic character that lingers close to the skin. The synthetic nature ensures a precise, consistent profile without the variability of natural pine extracts.
In Famous Fragrances
Fragrance associations may not reflect actual formulations.
Used to enhance the pine forest accord, providing a synthetic alternative to natural pine oils for consistent performance.
Contributes to the fresh woody opening, blending with lavender and citrus for a masculine fougère structure.
2D Molecular Structure
SMILES: [H][C@@]12C[C@@]([H])(C(CCO)=CC1)C2(C)C
Chemistry, Properties & Perfumer Guide
The Chemistry
(1R)-Nopol is a chiral monoterpenoid alcohol derived from β-pinene. Its synthesis typically involves the Prins reaction of β-pinene with formaldehyde. The (1R) enantiomer is preferred in perfumery for its superior odor characteristics. As a synthetic molecule, it offers consistent quality and sustainability advantages over natural pine oil extraction.
Physical & Chemical Properties
| Boiling Point | 198 °C |
|---|---|
| Density | 0.865 g/cm³ |
Perfumer Guide
| Application | Typical % | Range | Notes |
|---|---|---|---|
| Fine Fragrance | 1-3% | Up to 5% | Woody fresh modifier |
| Functional Products | 0.5-2% | Up to 3% | Clean pine note |
Classic Accords
Tip: Use in fougère compositions to enhance woody freshness without overpowering floral elements.
Alternatives & Comparisons
Safety, Regulatory & Sustainability
⚠ Regulatory Disclaimer
General reference only. Consult current IFRA Standards Library before formulating.
IFRA Status
No IFRA restrictions apply to (1R)-Nopol.
RIFM Assessment
RIFM has assessed (1R)-Nopol as safe for current use levels in fragrance applications.
Sustainability
As a synthetic material, (1R)-Nopol offers consistent quality without depleting natural pine resources. Its production from β-pinene, a byproduct of the paper industry, represents efficient utilization of existing materials. The process avoids the environmental impact of pine forest harvesting.
Explore (1R)-Nopol
Browse essential oils and aroma compounds.
Browse on iHerb →Affiliate disclosure: we may earn a small commission at no extra cost to you.
References
- PubChem: (1R)-Nopol CID 6436584
- Bauer et al. (2001). Common Fragrance and Flavor Materials.
Data: PubChem (NIH), PubMed, RIFM, IFRA. Last reviewed: Apr 2026.
Report a data errorPhysicochemical Properties
DTXSID: DTXSID601044956
Physical Properties
| Molecular Weight | 166.264 g/mol🔬 EPA CompTox |
| Density | 0.001 g/cm^3🔬 EPA CTX |
| Boiling Point | 235 °C🔬 EPA CTX |
| Melting Point | 50.077 °C📊 OPERA |
| Flash Point | 107 °C🔬 EPA CTX |
| Refractive Index | 1.501 Dimensionless📊 OPERA |
| Molar Volume | 169.991 cm^3/mol📊 OPERA |
Partition & Solubility
| LogP (Octanol-Water) | 3.09 Log10 unitless🔬 EPA CTX |
| LogD (pH 5.5) | 3.252 Log10 unitless📊 OPERA |
| LogD (pH 7.4) | 3.252 Log10 unitless📊 OPERA |
| LogKoa (Octanol-Air) | 7.71 Log10 unitless📊 OPERA |
| Water Solubility | 0.002 mol/L🔬 EPA CTX |
| Henry's Law Constant | 0 atm-m3/mole📊 OPERA |
Transport Properties
| Vapor Pressure | 0.024 mmHg🔬 EPA CTX |
| Viscosity | 15.212 cP📊 OPERA |
| Surface Tension | 31.705 dyn/cm📊 OPERA |
| Thermal Conductivity | 132.82 mW/(m*K)📊 OPERA |
Molecular Descriptors
| Topological Polar Surface Area | 20.23 Ų💻 Computed |
| H-Bond Donors | 1 count💻 Computed |
| H-Bond Acceptors | 1 count💻 Computed |
| Rotatable Bonds | 2 count💻 Computed |
| Aromatic Rings | 0 count💻 Computed |
| Molar Refractivity | 50.117 cm^3/mol📊 OPERA |
| Polarizability | 19.868 Å^3📊 OPERA |
Data Sources:
🔬 EPA Experimental data from U.S. EPA CompTox Chemicals Dashboard & CTX APIs. 📊 OPERA Predicted using EPA's OPERA QSAR models. 💻 Computed Calculated from SMILES using RDKit.
