(1R)-Nopyl acetate (CAS 35836-72-7) — Woody Middle Note Fragrance Ingredient
(1R)-Nopyl acetate
CAS 35836-72-7
What Is (1R)-Nopyl acetate?
(1R)-Nopyl acetate is a synthetic fragrance ingredient primarily used in professional perfumery. It’s found in niche fragrances where complex woody-green notes are desired. This molecule matters because it contributes unique terpenic facets that are difficult to replicate with natural materials, allowing perfumers to create novel accords.
Safety Profile
USE WITH AWARENESSWhat Does (1R)-Nopyl acetate Smell Like?
(1R)-Nopyl acetate presents a dynamic olfactory profile that evolves from crisp pine needle top notes to a heart of damp moss and cedar shavings. The drydown reveals subtle camphoraceous undertones reminiscent of antique wooden cabinets. Its character is simultaneously fresh and nostalgic, like a forest after rain meeting aged lumber.
2D Molecular Structure
SMILES: CC(=O)OCCC1=CC[C@H]2C[C@@H]1C2(C)C
Chemistry, Properties & Perfumer Guide
The Chemistry
As a chiral synthetic terpenoid ester, (1R)-Nopyl acetate is produced through stereoselective synthesis from pinene precursors. The (1R) enantiomer specifically contributes to its desirable olfactory properties. Industrial production typically involves catalytic hydrogenation followed by acetylation under controlled conditions to maintain optical purity.
Physical & Chemical Properties
| Appearance | Colorless to pale yellow liquid |
|---|---|
| Molecular Weight | Estimated ~220 g/mol |
Perfumer Guide
| Application | Typical % | Range | Notes |
|---|---|---|---|
| Fine Fragrance | 0.5-2% | Up to 5% | For woody-green accents |
| Functional Fragrance | 0.1-0.5% | Up to 1% | Cleaner applications |
Classic Accords
Tip: Use to add dimensionality to synthetic wood bases without overwhelming floral notes.
Alternatives & Comparisons
Safety, Regulatory & Sustainability
⚠ Regulatory Disclaimer
General reference only. Consult current IFRA Standards Library before formulating.
IFRA Status
No IFRA restrictions currently apply.
RIFM Assessment
Full RIFM assessment pending due to limited commercial use history.
Sustainability
As a synthetic material, (1R)-Nopyl acetate avoids natural resource depletion concerns. However, its production requires petrochemical inputs and energy-intensive purification processes. Future green chemistry approaches may improve its environmental footprint.
Explore (1R)-Nopyl acetate
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References
- PubChem Compound Summary CID N/A
Data: PubChem (NIH), PubMed, RIFM, IFRA. Last reviewed: Apr 2026.
Report a data errorPhysicochemical Properties
DTXSID: DTXSID40189368
Physical Properties
| Molecular Weight | 208.301 g/mol🔬 EPA CompTox |
| Density | 0.982 g/cm^3🔬 EPA CTX |
| Boiling Point | 253.455 °C📊 OPERA |
| Melting Point | 56.786 °C📊 OPERA |
| Flash Point | 111 °C🔬 EPA CTX |
| Refractive Index | 1.482 Dimensionless📊 OPERA |
| Molar Volume | 208.981 cm^3/mol📊 OPERA |
Partition & Solubility
| LogP (Octanol-Water) | 4.24 Log10 unitless🔬 EPA CTX |
| LogD (pH 5.5) | 4.029 Log10 unitless📊 OPERA |
| LogD (pH 7.4) | 4.029 Log10 unitless📊 OPERA |
| LogKoa (Octanol-Air) | 6.56 Log10 unitless📊 OPERA |
| Water Solubility | 0.001 mol/L📊 OPERA |
| Henry's Law Constant | 0 atm-m3/mole📊 OPERA |
Transport Properties
| Vapor Pressure | 0.015 mmHg🔬 EPA CTX |
| Viscosity | 6.117 cP📊 OPERA |
| Surface Tension | 30.659 dyn/cm📊 OPERA |
| Thermal Conductivity | 128.62 mW/(m*K)📊 OPERA |
Molecular Descriptors
| Topological Polar Surface Area | 26.3 Ų💻 Computed |
| H-Bond Donors | 0 count💻 Computed |
| H-Bond Acceptors | 2 count💻 Computed |
| Rotatable Bonds | 3 count💻 Computed |
| Aromatic Rings | 0 count💻 Computed |
| Molar Refractivity | 59.623 cm^3/mol📊 OPERA |
| Polarizability | 23.636 Å^3📊 OPERA |
Data Sources:
🔬 EPA Experimental data from U.S. EPA CompTox Chemicals Dashboard & CTX APIs. 📊 OPERA Predicted using EPA's OPERA QSAR models. 💻 Computed Calculated from SMILES using RDKit.
