Cyclohexane, 2-ethoxy-1,3-dimethyl- (CAS 286472-48-8) — Woody Middle Note Fragrance Ingredient
Cyclohexane, 2-ethoxy-1,3-dimethyl-
CAS 286472-48-8
What Is Cyclohexane, 2-ethoxy-1,3-dimethyl-?
Cyclohexane, 2-ethoxy-1,3-dimethyl- is a synthetic fragrance ingredient used in modern perfumery to create fresh, woody accords. It’s found in body sprays, laundry detergents, and some masculine fragrances. This versatile molecule helps perfumers build crisp, contemporary scent profiles that bridge natural and synthetic elements, particularly useful in mass-market formulations where stability and cost-effectiveness matter.
Safety Profile
USE WITH AWARENESSWhat Does Cyclohexane, 2-ethoxy-1,3-dimethyl- Smell Like?
This synthetic molecule opens with a sharp, almost metallic freshness reminiscent of crushed pine needles and freshly cut lumber. The initial burst evolves into a more rounded character – imagine the crispness of a winter morning blending with the oily sweetness of sandalwood sawdust. In drydown, it leaves a subtle woody-herbaceous trail with faint echoes of eucalyptus and dried sage. The overall effect is clean without being soapy, woody without heaviness, making it ideal for modern fougères and fresh oriental bases.
In Famous Fragrances
Fragrance associations may not reflect actual formulations.
Used as a woody-modifier to enhance the flinty mineral character, adding structural crispness to the vetiver heart without overwhelming the citrus top notes.
Employed in the woody-amber base to create an illusion of natural cedar while maintaining exceptional diffusion and shelf stability.
Chemistry, Properties & Perfumer Guide
The Chemistry
Cyclohexane, 2-ethoxy-1,3-dimethyl- belongs to the class of substituted cyclohexanes, specifically an ethoxy-dimethyl derivative. The ethoxy group at position 2 introduces polarity while the 1,3-dimethyl substitution creates steric hindrance affecting volatility. Synthesized through acid-catalyzed etherification of corresponding cyclohexanol precursors, this material demonstrates unusual stability for an ether-containing compound. The spatial arrangement of substituents creates a rigid molecular geometry that contributes to its clean, non-fatiguing odor profile.
Physical & Chemical Properties
| Appearance | Colorless to pale yellow liquid |
|---|---|
| Boiling Point | Estimated 190-210°C |
| Density | Estimated 0.85-0.90 g/cm³ |
Perfumer Guide
| Application | Typical % | Range | Notes |
|---|---|---|---|
| Fine Fragrance | 1-3% | Up to 5% | Woody accent in masculine accords |
| Functional Fragrance | 0.5-1.5% | Up to 3% | Freshness booster in detergents |
Classic Accords
Tip: Use with citrus terpenes to prevent woody notes from becoming too dry.
Alternatives & Comparisons
Safety, Regulatory & Sustainability
⚠ Regulatory Disclaimer
General reference only. Consult current IFRA Standards Library before formulating.
IFRA Status
Not currently restricted under IFRA standards.
RIFM Assessment
Under evaluation by RIFM as of 2023.
Sustainability
As a fully synthetic material, this ingredient avoids natural resource depletion but depends on petrochemical feedstocks. Production typically follows green chemistry principles with high atom economy. Biodegradability studies are pending, though structural similarity to known compounds suggests moderate environmental persistence.
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References
- IFRA Transparency List (2023) IFRA
Data: PubChem (NIH), PubMed, RIFM, IFRA. Last reviewed: Apr 2026.
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