3,3,5-Trimethylcyclohexyl ethyl ether (CAS 67583-77-1) — Woody Middle Note Fragrance Ingredient
3,3,5-Trimethylcyclohexyl ethyl ether
CAS 67583-77-1
What Is 3,3,5-Trimethylcyclohexyl ethyl ether?
3,3,5-Trimethylcyclohexyl ethyl ether is a synthetic fragrance ingredient used in modern perfumery. It contributes fresh, woody, and slightly floral notes to fragrances. You’ll encounter it in body sprays, deodorants, and some contemporary perfumes where a clean, outdoorsy scent is desired.
Safety Profile
GENERALLY SAFEWhat Does 3,3,5-Trimethylcyclohexyl ethyl ether Smell Like?
This ether delivers a crisp, transparent woody character with subtle floral undertones. Imagine the first breath of mountain air after rain – cool, slightly damp, with a whisper of pine needles. The initial burst evolves into a smoother, more rounded woodiness, like polished cedar panels in a sunlit room. Unlike heavier woods, it maintains an airy quality throughout its lifespan on skin, never becoming dense or oppressive.
In Famous Fragrances
Fragrance associations may not reflect actual formulations.
Used here to create the ‘driftwood’ accord, blending with ambroxan to suggest sun-bleached wood on coastal cliffs. Its clean profile prevents the marine notes from becoming fishy.
Provides a modern woody counterpoint to the classic vetiver base, adding lift and clarity to the earthy composition.
2D Molecular Structure
SMILES: CCOC1CC(C)CC(C)(C)C1
Chemistry, Properties & Perfumer Guide
The Chemistry
As a synthetic ether, this compound belongs to the cyclohexanol derivatives class. The trimethylcyclohexyl structure provides steric hindrance that influences volatility and odor characteristics. Industrial synthesis typically involves acid-catalyzed etherification of the corresponding alcohol with ethanol. The three methyl groups create multiple stereocenters, making chiral separation potentially important for odor quality control.
Physical & Chemical Properties
| Appearance | Colorless liquid |
|---|---|
| Boiling Point | Estimated 200-220°C |
| Density | ~0.85 g/cm³ (estimated) |
Perfumer Guide
| Application | Typical % | Range | Notes |
|---|---|---|---|
| Fine Fragrance | 1-3% | Up to 5% | Woody-modernist compositions |
| Functional Fragrance | 0.5-2% | Up to 3% | Deodorants and body sprays |
Classic Accords
Tip: Use to lighten dense woody bases without sacrificing longevity.
Alternatives & Comparisons
More pronounced woody character with less floral nuance. Better for formulations requiring stronger wood impact.
Safety, Regulatory & Sustainability
⚠ Regulatory Disclaimer
General reference only. Consult current IFRA Standards Library before formulating.
IFRA Status
Not currently restricted by IFRA standards.
RIFM Assessment
Under evaluation – preliminary data suggests low concern at current usage levels.
Sustainability
As a synthetic material, production avoids agricultural land use. Energy efficiency depends on manufacturing process optimization. Not known to bioaccumulate based on structure.
Explore 3,3,5-Trimethylcyclohexyl ethyl ether
Browse essential oils and aroma compounds.
Browse on iHerb →Affiliate disclosure: we may earn a small commission at no extra cost to you.
References
- Bauer, K. et al. (2001). Common Fragrance and Flavor Materials. Wiley-VCH.
Data: PubChem (NIH), PubMed, RIFM, IFRA. Last reviewed: Apr 2026.
Report a data errorPhysicochemical Properties
DTXSID: DTXSID1052872
Physical Properties
| Molecular Weight | 170.296 g/mol🔬 EPA CompTox |
| Density | 0.84 g/cm^3🔬 EPA CTX |
| Boiling Point | 184 °C🔬 EPA CTX |
| Melting Point | -21.918 °C📊 OPERA |
| Flash Point | 50 °C🔬 EPA CTX |
| Refractive Index | 1.44 Dimensionless📊 OPERA |
| Molar Volume | 199.593 cm^3/mol📊 OPERA |
Partition & Solubility
| LogP (Octanol-Water) | 3.91 Log10 unitless🔬 EPA CTX |
| LogD (pH 5.5) | 4.365 Log10 unitless📊 OPERA |
| LogD (pH 7.4) | 4.365 Log10 unitless📊 OPERA |
| LogKoa (Octanol-Air) | 4.97 Log10 unitless📊 OPERA |
| Water Solubility | 0 mol/L🔬 EPA CTX |
| Henry's Law Constant | 0.003 atm-m3/mole📊 OPERA |
Transport Properties
| Vapor Pressure | 1.658 mmHg🔬 EPA CTX |
| Viscosity | 2.561 cP📊 OPERA |
| Surface Tension | 26.608 dyn/cm📊 OPERA |
| Thermal Conductivity | 113.388 mW/(m*K)📊 OPERA |
Molecular Descriptors
| Topological Polar Surface Area | 9.23 Ų💻 Computed |
| H-Bond Donors | 0 count💻 Computed |
| H-Bond Acceptors | 1 count💻 Computed |
| Rotatable Bonds | 2 count💻 Computed |
| Aromatic Rings | 0 count💻 Computed |
| Molar Refractivity | 52.633 cm^3/mol📊 OPERA |
| Polarizability | 20.865 Å^3📊 OPERA |
Data Sources:
🔬 EPA Experimental data from U.S. EPA CompTox Chemicals Dashboard & CTX APIs. 📊 OPERA Predicted using EPA's OPERA QSAR models. 💻 Computed Calculated from SMILES using RDKit.
