4H-Indeno[4,5-D]-1,3-dioxole, 3a,5,6,7,8,8b-hexahydro-2,2,6,6,7,8,8-heptamethyl- (CAS 823178-41-2) — Musky Base Note Fragrance Ingredient

Musky · Sweet

4H-Indeno[4,5-D]-1,3-dioxole, 3a,5,6,7,8,8b-hexahydro-2,2,6,6,7,8,8-heptamethyl-

CAS 823178-41-2

Origin
synthetic
Note
Base
IFRA
Use with awareness
Data as of: Apr 2026

What Is 4H-Indeno[4,5-D]-1,3-dioxole, 3a,5,6,7,8,8b-hexahydro-2,2,6,6,7,8,8-heptamethyl-?

This synthetic musk compound is a modern fragrance ingredient used in laundry detergents, fabric softeners, and some personal care products. It provides long-lasting freshness to scented products. As a musk alternative, it offers stability and cost-effectiveness while meeting regulatory requirements for traditional musk ingredients.

Safety Profile

USE WITH AWARENESS
Generally safeUse with awarenessProfessional use
Approved for use in consumer products
Potential bioaccumulation concerns
CAS
823178-41-2
Formula
Mixture
MW
Variable
Odor Family
Musky · Sweet
Layer 1 · Enthusiast

What Does 4H-Indeno[4,5-D]-1,3-dioxole, 3a,5,6,7,8,8b-hexahydro-2,2,6,6,7,8,8-heptamethyl- Smell Like?

This synthetic musk presents a clean, powdery character with subtle floral undertones. The scent evolves from an initial crispness to a warm, skin-like dry down that lingers for hours. It blends invisibly with other notes while providing depth and persistence to fragrance compositions.

Scent Profile
Layer 2

Chemistry, Properties & Perfumer Guide

The Chemistry

This polycyclic musk belongs to the indane class of synthetic musks, structurally designed to mimic natural musk compounds while avoiding nitro-musk toxicity. The molecule features a rigid indane core with multiple methyl groups that influence its odor profile and stability. Modern synthesis routes typically involve catalytic cyclization and methylation steps to achieve the final structure.

Physical & Chemical Properties

Boiling PointNot available
DensityNot available

Perfumer Guide

Note Position
Base
Volatility
Very low (8+ hours)
Blending
Good
ApplicationTypical %RangeNotes
Laundry Care0.1-0.5%Up to 1%Provides lasting freshness
Personal Care0.05-0.2%Up to 0.5%Used as musk base note

Classic Accords

Tip: Use in combination with other musks to create depth without overpowering.

Alternatives & Comparisons

1
Galaxolide CAS 1222-05-5

More powerful musk with similar stability profile, often used when higher intensity is desired.

2
Ethylene Brassylate CAS 105-95-3

Softer musk alternative with better biodegradability profile.

Layer 3

Safety, Regulatory & Sustainability

⚠ Regulatory Disclaimer

General reference only. Consult current IFRA Standards Library before formulating.

IFRA Status

No current IFRA restrictions. Approved under Amendment 49.

RIFM Assessment

Under ongoing safety assessment by RIFM. Preliminary data shows acceptable toxicological profile.

Sustainability

As a synthetic ingredient, this musk avoids animal-derived sourcing concerns but raises questions about environmental persistence. Manufacturers are developing more biodegradable versions while maintaining performance characteristics. Current production methods have relatively low carbon footprint compared to natural musk alternatives.

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References

    Data: PubChem (NIH), PubMed, RIFM, IFRA. Last reviewed: Apr 2026.

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