D-Mannitol (CAS 69-65-8) — Citrus N/A Note Fragrance Ingredient

ByThe Good Scents
Citrus · Floral

D-Mannitol

CAS 69-65-8

Origin
synthetic
Note
N/A
IFRA
Generally safe
Data as of: Apr 2026

What Is D-Mannitol?

D-Mannitol is a sugar alcohol primarily used as a bulking agent in sugar-free foods and pharmaceuticals. You’ll find it in chewing gum, hard candies, and some medications. While odorless itself, it plays a supporting role in fragrance formulations by modifying texture and stabilizing volatile aroma compounds.

Safety Profile

GENERALLY SAFE
Generally safeUse with awarenessProfessional use
✓ FDA-approved food additive
✓ Non-toxic and non-allergenic
CAS
69-65-8
Formula
Mixture
MW
Variable
Odor Family
Citrus · Floral
Layer 1 · Enthusiast

What Does D-Mannitol Smell Like?

D-Mannitol is completely odorless, presenting as a neutral olfactory blank slate. Its value lies in its physical properties rather than aromatic contribution – this crystalline powder modifies mouthfeel in fragrance applications, provides body to alcohol-free formulations, and can help stabilize volatile top notes without altering scent profiles.

Layer 2

2D Molecular Structure

D-Mannitol

SMILES: OC[C@@H](O)[C@@H](O)[C@H](O)[C@H](O)CO

Chemistry, Properties & Perfumer Guide

The Chemistry

D-Mannitol is a hexahydric alcohol and stereoisomer of sorbitol, belonging to the sugar alcohol (polyol) family. Industrially produced by hydrogenation of fructose or via fermentation processes. Its six hydroxyl groups make it highly water-soluble and hygroscopic. The D-isomer is naturally occurring while L-mannitol is synthetic.

Physical & Chemical Properties

Melting Point165-168 °C
Solubility22 g/100 mL water (25°C)

Perfumer Guide

Note Position
N/A
Volatility
Non-volatile
Blending
Texture modifier
ApplicationTypical %RangeNotes
Alcohol-free perfumes2-5%Up to 10%Provides body and viscosity
Solid perfumes5-15%Up to 25%Bulking agent

Classic Accords

Tip: Use as a crystallization inhibitor in high-alcohol fragrances by pre-dissolving in water before adding ethanol.

Alternatives & Comparisons

1
Sorbitol CAS 50-70-4

Similar polyol with higher hygroscopicity, better suited for humectant applications but may feel stickier on skin.

2
Xylitol CAS 87-99-0

Sugar alcohol with superior cooling effect, preferred for minty or fresh fragrance applications.

Layer 3

Safety, Regulatory & Sustainability

⚠ Regulatory Disclaimer

General reference only. Consult current IFRA Standards Library before formulating.

IFRA Status

No IFRA restrictions – exempt from limitation as non-volatile material.

RIFM Assessment

RIFM considers mannitol safe for all fragrance applications with no sensitization concerns.

Sustainability

Primarily synthesized from corn-derived glucose via catalytic hydrogenation. Considered environmentally benign due to complete biodegradability. Production energy requirements are moderate compared to other polyols. Some manufacturers offer plant-derived versions using fermentation processes.

Explore D-Mannitol

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References

  1. FDA (2021). Code of Federal Regulations Title 21. 21CFR180.25
  2. FEMA (2020). GRAS Assessment of Mannitol. FEMA 3649

Data: PubChem (NIH), PubMed, RIFM, IFRA. Last reviewed: Apr 2026.

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Ingredient Data Sheet

CAS 69-65-8

Physical Properties

Molecular Weight182.17 g/mol🔬 PubChem
LogP (Octanol-Water)-3.1🔬 PubChem
Boiling Point295 °C🔬 EPA CompTox
Flash Point148.9 °C🔬 EPA CompTox
log Kp (skin permeability)-6.012💻 Calculated
SMILESC(C(C(C(C(CO)O)O)O)O)O🔬 PubChem

Volatility & Performance

Fragrance NoteBase💻 Calculated

Odor & Flavor

Functional Groupsalcohol💻 RDKit
Data Sources & Attribution
Physical data: PubChem (NIH/NLM), U.S. EPA CompTox Dashboard, EPA OPERA models, RDKit. Odor & flavor: Arctander (Perfume & Flavor Chemicals), Fenaroli's Handbook of Flavor Ingredients, Leffingwell. Thresholds: van Gemert (Compilations of Odour Threshold Values). Regulatory: IFRA Standards 51st, FEMA GRAS. Trade names: Surburg (Common Fragrance & Flavor Materials). All data compiled and cross-referenced for perfumertools.com.

Physicochemical Properties

DTXSID: DTXSID1023235

Physical Properties

Molecular Weight 182.172 g/mol🔬 EPA CompTox
Density 1.505 g/cm^3🔬 EPA CTX
Boiling Point 292.5 °C🔬 EPA CTX
Melting Point 170.787 °C🔬 EPA CTX
Flash Point 292.549 °C🔬 EPA CTX
Refractive Index 1.597 Dimensionless📊 OPERA
Molar Volume 114.118 cm^3/mol📊 OPERA

Partition & Solubility

LogP (Octanol-Water) -2.875 Log10 unitless🔬 EPA CTX
LogD (pH 5.5) -2.837 Log10 unitless📊 OPERA
LogD (pH 7.4) -2.862 Log10 unitless📊 OPERA
LogKoa (Octanol-Air) 8.46 Log10 unitless📊 OPERA
Water Solubility 1.161 mol/L🔬 EPA CTX
Henry's Law Constant 0 atm-m3/mole🔬 EPA CTX

Transport Properties

Vapor Pressure 0 mmHg📊 OPERA
Viscosity 6.034 cP📊 OPERA
Surface Tension 73.924 dyn/cm📊 OPERA

Molecular Descriptors

Topological Polar Surface Area 121.38 Ų💻 Computed
H-Bond Donors 6 count💻 Computed
H-Bond Acceptors 6 count💻 Computed
Rotatable Bonds 5 count💻 Computed
Aromatic Rings 0 count💻 Computed
Molar Refractivity 38.89 cm^3/mol📊 OPERA
Polarizability 15.417 Å^3📊 OPERA

Data Sources:

🔬 EPA Experimental data from U.S. EPA CompTox Chemicals Dashboard & CTX APIs. 📊 OPERA Predicted using EPA's OPERA QSAR models. 💻 Computed Calculated from SMILES using RDKit.

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