Methyl Propyl Disulfide (CAS 2179-60-4) — Top Note Fragrance Ingredient
Methyl Propyl Disulfide
CAS 2179-60-4
What Is Methyl Propyl Disulfide?
Methyl Propyl Disulfide (CAS 2179-60-4) is an aroma chemical used as a fragrance and flavour ingredient. Its odour is described as sulfurous, onion and garlic, placing it as a top note with high volatility. With a molecular weight of 122.2 (formula C4H10S2), it is handled by perfumers as a building block for compositions where a sulfurous character is desired. The data below is compiled from public chemical and regulatory sources.
Safety Profile
USE WITH AWARENESS
What Does Methyl Propyl Disulfide Smell Like?
The odour profile of Methyl Propyl Disulfide is reported as sulfurous, onion, garlic, pungent, alliaceous, meaty, spicy. The dominant facet is its sulfurous character, with the remaining notes adding nuance and complexity. As a top note it contributes to the opening of a fragrance. Perceived intensity and exact character depend on concentration, the carrier and the surrounding accord.
Scent Profile
Profile derived from public odour-descriptor data; relative, not absolute.
Chemistry & Properties
The Chemistry
Methyl Propyl Disulfide has the molecular formula C4H10S2 and a molecular weight of 122.2 g/mol. Its canonical SMILES representation is CCCSSC. Its reported log P (XLogP) of 2.41 indicates a lipophilic, oil-soluble molecule, which informs how it partitions in a formula. Physical constants below are drawn from PubChem and EPA CompTox public datasets.
Physical & Chemical Properties
| Molecular Weight | 122.2 g/mol |
|---|---|
| Boiling Point | 154.1 °C |
| Melting Point | -45.68 °C |
| Flash Point | 44.72 °C |
| Density | 0.9945 g/cm³ |
| Vapor Pressure | 4.14 mmHg |
| Water Solubility | 0.01282 g/L |
| XLogP | 2.41 |
Perfumer Guide
Alternatives & Comparisons
Ingredients occupying a similar odour space — useful as substitutes or companions when Methyl Propyl Disulfide is unavailable or restricted.
Shares sulfurous, onion, garlic character — a candidate substitute or companion in the same odour space.
Shares pungent, peppery, mustard character — a candidate substitute or companion in the same odour space.
Shares sweet, fish, garlic character — a candidate substitute or companion in the same odour space.
Safety & Regulatory
⚠ Regulatory Disclaimer
General reference only. IFRA, REACH and EU Cosmetics Regulation standards update periodically. Consult the current IFRA Standards Library before formulating. Not legal or regulatory advice.
IFRA Status
No IFRA restriction recorded in the data set. This is not a guarantee of unrestricted status — always confirm against the current IFRA Standards Library.
GHS Classification
Signal word: Warning
Odour detection threshold (air): 0.00056 ppb — a literature-curated value indicating its potency in the vapour phase.
Open Methyl Propyl Disulfide in Fragrance Studio (Pro) for the calibrated vapour-pressure curve, the modelled odour-threshold estimate, and the substitute-matching engine across 2,900+ aromachemicals.
References & Sources
- PubChem Compound Summary (NIH) — search by InChIKey
- EPA CompTox Chemicals Dashboard — physicochemical & fate data
- IFRA Standards Library (49th / 51st Amendment)
Data: PubChem (NIH), EPA CompTox, IFRA. Last reviewed: Jun 2026.
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