Myristo nitrile (CAS 629-63-0) — Balsamic Middle Note Fragrance Ingredient

ByThe Good Scents
Balsamic · Woody

Myristo nitrile

CAS 629-63-0

Origin
synthetic
Note
Middle
IFRA
Use with awareness
Data as of: Apr 2026

What Is Myristo nitrile?

Myristo nitrile is a synthetic fragrance ingredient primarily used in perfumery to add a clean, slightly fatty character to compositions. It’s found in some body care products and detergents where a subtle, long-lasting note is desired. This nitrile compound matters because it provides stability in formulations where traditional fatty notes might degrade, offering perfumers a reliable building block for modern, functional fragrances with good longevity.

Safety Profile

USE WITH AWARENESS
Generally safeUse with awarenessProfessional use
✓ Stable in formulations
⚠ Limited safety data available
CAS
629-63-0
Formula
Mixture
MW
Variable
Odor Family
Balsamic · Woody
Layer 1 · Enthusiast

What Does Myristo nitrile Smell Like?

Myristo nitrile presents a clean, slightly fatty odor reminiscent of freshly washed laundry with a subtle waxy undertone. The scent evolves from a crisp opening to a softer, more diffuse character over time, behaving like a quiet harmonic in fragrance compositions rather than a dominant note. It lacks the buttery depth of true fatty acids, instead offering a transparent quality that supports other materials without overwhelming them. In dry-down, it leaves a faint, pleasant skin-like impression that enhances the perceived cleanliness of a fragrance.

Scent Profile
Layer 2

2D Molecular Structure

Tetradecanenitrile

SMILES: CCCCCCCCCCCCCC#N

Chemistry, Properties & Perfumer Guide

The Chemistry

Myristo nitrile belongs to the aliphatic nitrile class, characterized by a cyano group (-CN) attached to a tetradecyl chain. As a synthetic material, it’s produced through nitrile synthesis from myristic acid derivatives or via controlled oxidation of corresponding amines. The molecule lacks chirality, existing as a single structural isomer. Its stability comes from the strong carbon-nitrogen triple bond, which resists hydrolysis better than ester groups while maintaining moderate volatility for fragrance applications.

Physical & Chemical Properties

Boiling PointNot well documented
DensityNot well documented

Perfumer Guide

Note Position
Middle
Volatility
Moderate (2-4 hours)
Blending
Good
ApplicationTypical %RangeNotes
Fine Fragrance0.5-2%Up to 5%Background note enhancer
Functional Fragrances1-3%Up to 8%Clean note booster
Household Products0.1-1%Up to 3%Longevity improver

Classic Accords

Tip: Use with citrus top notes to prevent harshness in detergent fragrances.

Alternatives & Comparisons

1
Tetradecanal CAS 124-25-4

Offers similar fatty character but with more pronounced aldehyde freshness, better for top notes.

2
Myristic acid CAS 544-63-8

Natural fatty acid alternative when a warmer, more buttery profile is desired.

Layer 3

Safety, Regulatory & Sustainability

⚠ Regulatory Disclaimer

General reference only. Consult current IFRA Standards Library before formulating.

IFRA Status

Not currently restricted by IFRA standards.

RIFM Assessment

No specific RIFM assessment found for this material.

Sustainability

As a synthetic material, myristo nitrile avoids agricultural impacts but requires petrochemical feedstocks. Production typically occurs in controlled industrial settings with standard chemical manufacturing waste management. The material’s stability may reduce the need for frequent reapplication in end products, potentially offering some lifecycle advantages over less persistent ingredients.

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References

    Data: PubChem (NIH), PubMed, RIFM, IFRA. Last reviewed: Apr 2026.

    Report a data error

    Layer 3 · Practical

    • Molecular Weight: 209.37 g/mol
    • LogP (XLogP): 5.80

    Ingredient Data Sheet

    CAS 629-63-0

    Physical Properties

    Molecular Weight209.37 g/mol🔬 PubChem
    LogP (Octanol-Water)5.8🔬 PubChem
    Boiling Point301 °C🔬 EPA CompTox
    Vapor Pressure0.005 mmHg @ 25°C📊 OPERA
    Flash Point121.8 °C🔬 EPA CompTox
    Involatility Index0.0004💻 Calculated
    log Kp (skin permeability)0.141💻 Calculated
    SMILESCCCCCCCCCCCCCC#N🔬 PubChem

    Volatility & Performance

    Fragrance NoteBase💻 Calculated
    Volatility ClassVery slow💻 Calculated
    Persistence Score6 / 5💻 Calculated

    Odor & Flavor

    “Very powerful, in dilution refreshingly citrusy, in concentration rather choking, pungent odor of considerable tenacity, and with an undertone of fresh Oakmoss.”📖 Arctander
    Data Sources & Attribution
    Physical data: PubChem (NIH/NLM), U.S. EPA CompTox Dashboard, EPA OPERA models, RDKit. Odor & flavor: Arctander (Perfume & Flavor Chemicals), Fenaroli's Handbook of Flavor Ingredients, Leffingwell. Thresholds: van Gemert (Compilations of Odour Threshold Values). Regulatory: IFRA Standards 51st, FEMA GRAS. Trade names: Surburg (Common Fragrance & Flavor Materials). All data compiled and cross-referenced for perfumertools.com.

    Physicochemical Properties

    DTXSID: DTXSID3060877

    Physical Properties

    Molecular Weight 209.377 g/mol🔬 EPA CompTox
    Density 0.826 g/cm^3📊 OPERA
    Boiling Point 306.668 °C📊 OPERA
    Melting Point 19 °C🔬 EPA CTX
    Flash Point 122.87 °C📊 OPERA
    Refractive Index 1.441 Dimensionless📊 OPERA
    Molar Volume 253.013 cm^3/mol📊 OPERA

    Partition & Solubility

    LogP (Octanol-Water) 6.387 Log10 unitless📊 OPERA
    LogD (pH 5.5) 6.387 Log10 unitless📊 OPERA
    LogD (pH 7.4) 6.387 Log10 unitless📊 OPERA
    LogKoa (Octanol-Air) 7.44 Log10 unitless📊 OPERA
    Water Solubility 0 mol/L📊 OPERA
    Henry's Law Constant 0 atm-m3/mole📊 OPERA

    Transport Properties

    Vapor Pressure 0.002 mmHg📊 OPERA
    Viscosity 6.622 cP📊 OPERA
    Surface Tension 30.601 dyn/cm📊 OPERA
    Thermal Conductivity 158.842 mW/(m*K)📊 OPERA

    Molecular Descriptors

    Topological Polar Surface Area 23.79 Ų💻 Computed
    H-Bond Donors 0 count💻 Computed
    H-Bond Acceptors 1 count💻 Computed
    Rotatable Bonds 11 count💻 Computed
    Aromatic Rings 0 count💻 Computed
    Molar Refractivity 66.823 cm^3/mol📊 OPERA
    Polarizability 26.491 Å^3📊 OPERA

    Data Sources:

    🔬 EPA Experimental data from U.S. EPA CompTox Chemicals Dashboard & CTX APIs. 📊 OPERA Predicted using EPA's OPERA QSAR models. 💻 Computed Calculated from SMILES using RDKit.

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