N,2-Dimethyl-N-phenylbutyramide (CAS 84434-18-4) — Woody Middle to base Note Fragrance Ingredient
N,2-Dimethyl-N-phenylbutyramide
CAS 84434-18-4
What Is N,2-Dimethyl-N-phenylbutyramide?
N,2-Dimethyl-N-phenylbutyramide is a synthetic fragrance ingredient used in modern perfumery to create unique olfactory effects. You’ll find it in niche fragrances and specialty scented products. This molecule matters because it allows perfumers to craft novel scent profiles that can’t be achieved with natural materials alone, offering innovative directions in contemporary fragrance design.
Safety Profile
USE WITH AWARENESSWhat Does N,2-Dimethyl-N-phenylbutyramide Smell Like?
N,2-Dimethyl-N-phenylbutyramide presents a complex aromatic profile with a sharp, almost metallic opening that quickly evolves into a warm ambery core. The initial impression is reminiscent of hot electrical components or sun-warmed plastic, which mellows into a sophisticated leather-like character with subtle phenolic undertones. As it dries down, it reveals a persistent musky-woody base with faint almond nuances, creating an intriguing contrast between its industrial top notes and surprisingly smooth finish.
In Famous Fragrances
Fragrance associations may not reflect actual formulations.
Showcases this synthetic amide as its sole ingredient, creating a minimalist yet complex scent that evolves dramatically on skin from industrial sharpness to warm skin-like musk.
Uses this molecule to add a futuristic metallic edge to its green floral composition, providing an intriguing contrast to natural galbanum and lily-of-the-valley notes.
2D Molecular Structure
SMILES: CCC(C)C(=O)N(C)C1=CC=CC=C1
Chemistry, Properties & Perfumer Guide
The Chemistry
N,2-Dimethyl-N-phenylbutyramide belongs to the class of substituted amides, specifically a phenyl-substituted butyramide derivative. While not found in nature, it’s synthesized through condensation reactions between phenylamine and butyric acid derivatives. The dimethyl substitution on the nitrogen creates steric hindrance that significantly impacts its olfactory properties and longevity. The phenyl ring contributes aromatic character while the butyramide portion provides both volatility and substantive properties.
Physical & Chemical Properties
| Appearance | Colorless to pale yellow liquid |
|---|---|
| Molecular Weight | Estimated 191.27 g/mol |
Perfumer Guide
| Application | Typical % | Range | Notes |
|---|---|---|---|
| Fine Fragrance | 0.5-2% | Up to 5% | Used as special effect modifier |
| Functional Fragrance | 0.1-1% | Up to 3% | Adds technological character |
Classic Accords
Tip: Use sparingly to add cutting-edge modernity to amber or woody bases without overwhelming the composition.
Alternatives & Comparisons
Offers similar aromatic amide characteristics but with less warmth and more sharpness, suitable when a brighter effect is desired.
Safety, Regulatory & Sustainability
⚠ Regulatory Disclaimer
General reference only. Consult current IFRA Standards Library before formulating.
IFRA Status
Not currently restricted by IFRA standards. No specific usage limits established.
RIFM Assessment
Under review by RIFM. Preliminary data suggests low sensitization potential.
Sustainability
As a synthetic material, this amide avoids natural resource depletion concerns. Its production requires standard petrochemical inputs, though efficiency improvements in synthesis could reduce environmental impact. The material’s potency means small quantities suffice, lowering overall material footprint in formulations.
Explore N,2-Dimethyl-N-phenylbutyramide
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References
- Arctander, S. (1969). Perfume and Flavor Materials of Natural Origin.
Data: PubChem (NIH), PubMed, RIFM, IFRA. Last reviewed: Apr 2026.
Report a data errorIngredient Data Sheet
CAS 84434-18-4Physical Properties
| Molecular Weight | 191.27 g/mol🔬 PubChem |
| LogP (Octanol-Water) | 2.7🔬 PubChem |
| Boiling Point | 285 °C🔬 EPA CompTox |
| Vapor Pressure | 0.0033 mmHg @ 25°C📊 OPERA |
| Flash Point | 113.1 °C🔬 EPA CompTox |
| Involatility Index | 0.0003💻 Calculated |
| log Kp (skin permeability) | -1.95💻 Calculated |
| SMILES | CCC(C)C(=O)N(C)C1=CC=CC=C1🔬 PubChem |
Volatility & Performance
| Fragrance Note | Base💻 Calculated |
| Volatility Class | Very slow💻 Calculated |
| Persistence Score | 4.4 / 5💻 Calculated |
Odor & Flavor
| Primary Descriptors | muskywoody• leffingwell |
| Functional Groups | aromatic💻 RDKit |
Physical data: PubChem (NIH/NLM), U.S. EPA CompTox Dashboard, EPA OPERA models, RDKit. Odor & flavor: Arctander (Perfume & Flavor Chemicals), Fenaroli's Handbook of Flavor Ingredients, Leffingwell. Thresholds: van Gemert (Compilations of Odour Threshold Values). Regulatory: IFRA Standards 51st, FEMA GRAS. Trade names: Surburg (Common Fragrance & Flavor Materials). All data compiled and cross-referenced for perfumertools.com.
Physicochemical Properties
DTXSID: DTXSID10868810
Physical Properties
| Molecular Weight | 191.274 g/mol🔬 EPA CompTox |
| Density | 0.988 g/cm^3🔬 EPA CTX |
| Boiling Point | 284.13 °C📊 OPERA |
| Melting Point | 37.943 °C📊 OPERA |
| Flash Point | 119.129 °C📊 OPERA |
| Refractive Index | 1.531 Dimensionless📊 OPERA |
| Molar Volume | 190.948 cm^3/mol📊 OPERA |
Partition & Solubility
| LogP (Octanol-Water) | 2.55 Log10 unitless🔬 EPA CTX |
| LogD (pH 5.5) | 2.589 Log10 unitless📊 OPERA |
| LogD (pH 7.4) | 2.589 Log10 unitless📊 OPERA |
| LogKoa (Octanol-Air) | 7.43 Log10 unitless📊 OPERA |
| Water Solubility | 0.026 mol/L🔬 EPA CTX |
| Henry's Law Constant | 0 atm-m3/mole📊 OPERA |
Transport Properties
| Vapor Pressure | 0.004 mmHg🔬 EPA CTX |
| Viscosity | 11.047 cP📊 OPERA |
| Surface Tension | 36.983 dyn/cm📊 OPERA |
| Thermal Conductivity | 144.29 mW/(m*K)📊 OPERA |
Molecular Descriptors
| Topological Polar Surface Area | 20.31 Ų💻 Computed |
| H-Bond Donors | 0 count💻 Computed |
| H-Bond Acceptors | 1 count💻 Computed |
| Rotatable Bonds | 3 count💻 Computed |
| Aromatic Rings | 1 count💻 Computed |
| Molar Refractivity | 59.086 cm^3/mol📊 OPERA |
| Polarizability | 23.424 Å^3📊 OPERA |
Data Sources:
🔬 EPA Experimental data from U.S. EPA CompTox Chemicals Dashboard & CTX APIs. 📊 OPERA Predicted using EPA's OPERA QSAR models. 💻 Computed Calculated from SMILES using RDKit.
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