Oils, sandalwood, santalene synthase-modified Rhodobacter sphaeroides-fermented, from D-Glucose, oxidized (CAS 2576531-09-2) — Woody Base Note Fragrance Ingredient

ByThe Good Scents
Woody · Balsamic

Oils, sandalwood, santalene synthase-modified Rhodobacter sphaeroides-fermented, from D-Glucose, oxidized

CAS 2576531-09-2

Origin
synthetic
Note
Base
IFRA
Generally safe
Data as of: Apr 2026

What Is Oils, sandalwood, santalene synthase-modified Rhodobacter sphaeroides-fermented, from D-Glucose, oxidized?

This is a lab-created sandalwood alternative produced through advanced biotechnological fermentation. It appears in niche perfumes and body care products. The ingredient matters because it provides a sustainable, ethical sandalwood aroma without harvesting endangered trees, with consistent quality and supply chain transparency.

Safety Profile

GENERALLY SAFE
Generally safeUse with awarenessProfessional use
✓ No known restrictions
⚠ New technology – monitor research
CAS
2576531-09-2
Formula
Mixture
MW
Variable
Odor Family
Woody · Balsamic
Layer 1 · Enthusiast

What Does Oils, sandalwood, santalene synthase-modified Rhodobacter sphaeroides-fermented, from D-Glucose, oxidized Smell Like?

A modern interpretation of sandalwood’s creamy warmth with enhanced clarity. Opens with bright woody facets reminiscent of freshly sanded cedar, transitioning into a velvety heart of milky santalols with subtle coconut undertones. The dry-down reveals an unexpected mineral crispness like sun-warmed stones, with none of traditional sandalwood’s occasional mustiness. Exceptionally smooth diffusion with zero harsh edges.

Scent Profile
Layer 2

Chemistry, Properties & Perfumer Guide

The Chemistry

Produced via metabolic engineering of Rhodobacter sphaeroides bacteria modified with santalene synthase genes. The microorganisms convert D-glucose into santalene precursors through fermentation, followed by controlled oxidation to create santalol analogs. This biotech route yields consistent stereochemistry without plant-derived variability. The process avoids traditional steam distillation’s thermal degradation of delicate sandalwood compounds.

Physical & Chemical Properties

AppearancePale golden viscous liquid
SolubilitySoluble in ethanol and oils

Perfumer Guide

Note Position
Base
Volatility
Very high (>12 hours)
Blending
Excellent
ApplicationTypical %RangeNotes
Fine Fragrance2-5%Up to 10%Sandalwood replacer
Body Care0.5-2%Up to 3%Luxury skin feel
Functional0.1-0.5%Up to 1%Fabric softeners

Classic Accords

Tip: Use as 1:1 replacement for East Indian sandalwood oil in accords requiring regulatory compliance.

Alternatives & Comparisons

1
Amyris oil CAS 8015-65-4

Budget-friendly West Indian sandalwood substitute with brighter, less creamy profile. Contains higher sesquiterpene content.

2
Santaliff CAS 65113-99-7

Synthetic sandalwood base with stronger alpha-santalol character. Better for traditional reconstructions but less sustainable.

Layer 3

Safety, Regulatory & Sustainability

⚠ Regulatory Disclaimer

General reference only. Consult current IFRA Standards Library before formulating.

IFRA Status

No restrictions under current IFRA standards (Amendment 49). Not classified as sandalwood oil proper.

RIFM Assessment

Under evaluation via Read-Across approach using santalol data. Preliminary assessment suggests comparable safety profile.

Sustainability

Represents a breakthrough in green chemistry, reducing pressure on endangered Santalum album populations. Fermentation from glucose uses renewable feedstocks with 78% lower carbon footprint than traditional cultivation. Water usage is 95% less than sandalwood agriculture. No deforestation or long growth cycles required.

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References

  1. Firmenich SA Patent WO2019081327 Fermentation Process
  2. Givaudan Sustainability Report 2022 Biotech Ingredients

Data: PubChem (NIH), PubMed, RIFM, IFRA. Last reviewed: Apr 2026.

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Ingredient Data Sheet

CAS 2576531-09-2
Data Sources & Attribution
Physical data: PubChem (NIH/NLM), U.S. EPA CompTox Dashboard, EPA OPERA models, RDKit. Odor & flavor: Arctander (Perfume & Flavor Chemicals), Fenaroli's Handbook of Flavor Ingredients, Leffingwell. Thresholds: van Gemert (Compilations of Odour Threshold Values). Regulatory: IFRA Standards 51st, FEMA GRAS. Trade names: Surburg (Common Fragrance & Flavor Materials). All data compiled and cross-referenced for perfumertools.com.

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