Piperonyl acetate (CAS 326-61-4) — Floral Middle Note Fragrance Ingredient

Floral · Sweet

Piperonyl acetate

CAS 326-61-4

Origin
synthetic
Note
Middle
IFRA
Generally safe
Data as of: Apr 2026

What Is Piperonyl acetate?

Piperonyl acetate is a synthetic fragrance ingredient with a sweet, floral, and slightly spicy aroma. It’s commonly found in perfumes, soaps, and air fresheners. This versatile compound adds warmth and depth to fragrance compositions, often blending well with other floral and woody notes.

Safety Profile

GENERALLY SAFE
Generally safeUse with awarenessProfessional use
Safe in regulated products
Check for individual sensitivity
CAS
326-61-4
Formula
Mixture
MW
Variable
Odor Family
Floral · Sweet
Layer 1 · Enthusiast

What Does Piperonyl acetate Smell Like?

Piperonyl acetate unfolds with an initial burst of sweet, floral notes reminiscent of heliotrope and vanilla, with a subtle spicy undertone. As it evolves, the heart reveals a warm, powdery character that blends seamlessly into the base, where it leaves a soft, slightly woody trail. The dry-down is persistent yet gentle, making it excellent for creating long-lasting floral accords without overwhelming the composition.

Scent Profile
Layer 2

Chemistry, Properties & Perfumer Guide

The Chemistry

Piperonyl acetate is an ester derived from piperonyl alcohol and acetic acid. It belongs to the class of aromatic esters, known for their sweet and floral olfactory properties. The compound is typically synthesized through esterification reactions, where piperonyl alcohol reacts with acetic anhydride or acetyl chloride in the presence of a catalyst. Its molecular structure features a benzodioxole ring, which contributes to its distinctive aroma profile.

Physical & Chemical Properties

Boiling PointNot available
DensityNot available

Perfumer Guide

Note Position
Middle
Volatility
Medium (2-6 hours)
Blending
Good
ApplicationTypical %RangeNotes
Fine Fragrance1-5%Up to 10%Adds floral warmth
Soap0.5-3%Up to 5%Stable in alkaline conditions
Detergents0.1-1%Up to 2%Provides lasting freshness

Classic Accords

Tip: Use in moderation to avoid overpowering other floral notes in the composition.

Alternatives & Comparisons

1
Heliotropin CAS 120-57-0

Offers similar sweet floral character but with more pronounced powdery notes.

2
Benzyl acetate CAS 140-11-4

Provides a brighter floral note with less sweetness and spice.

Layer 3

Safety, Regulatory & Sustainability

⚠ Regulatory Disclaimer

General reference only. Consult current IFRA Standards Library before formulating.

IFRA Status

No IFRA restrictions currently apply to piperonyl acetate.

RIFM Assessment

RIFM has evaluated piperonyl acetate and found it safe for use in current fragrance applications.

Sustainability

As a synthetic material, piperonyl acetate production doesn’t rely on natural resources. Modern manufacturing processes aim to minimize environmental impact through efficient synthesis routes and waste reduction. Being petroleum-derived, its sustainability depends on the broader petrochemical industry’s environmental practices.

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References

    Data: PubChem (NIH), PubMed, RIFM, IFRA. Last reviewed: Apr 2026.

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