Pyrazine, 2-ethyl-3-methoxy- (CAS 25680-58-4) — Green Top to heart Note Fragrance Ingredient
Pyrazine, 2-ethyl-3-methoxy-
CAS 25680-58-4
What Is Pyrazine, 2-ethyl-3-methoxy-?
2-Ethyl-3-methoxypyrazine is a synthetic aroma chemical that creates earthy, green, and bell pepper-like scents. It’s found in perfumes and some food flavorings. This molecule matters because it’s incredibly potent – just tiny amounts can transform a fragrance, adding realistic vegetable garden or forest floor nuances.
Safety Profile
USE WITH AWARENESSWhat Does Pyrazine, 2-ethyl-3-methoxy- Smell Like?
A powerhouse of vegetal realism, 2-ethyl-3-methoxypyrazine bursts with crushed green bell pepper, fresh pea pods, and damp earth. The initial sharpness evolves into a sophisticated earthy heart reminiscent of truffles and forest undergrowth. At ultra-dilute concentrations, it contributes a mysterious green nuance that lingers subtly in the dry-down. This molecule is famously responsible for the characteristic ‘green’ smell of bell peppers at just parts-per-billion concentrations.
In Famous Fragrances
Fragrance associations may not reflect actual formulations.
Used minimally to enhance the ink-like earthiness, contributing to the fragrance’s stark, damp forest character without overpowering the vetiver.
Provides subtle vegetal undertones that complement the violet leaf, creating a dewy morning garden effect.
Chemistry, Properties & Perfumer Guide
The Chemistry
2-Ethyl-3-methoxypyrazine belongs to the alkylmethoxypyrazine class, known for their extremely low odor thresholds. While found naturally in bell peppers and certain wines (as ‘ladybug taint’), commercial versions are synthesized. Key production methods include condensation reactions of dihydrazines with diketones followed by methylation. The methoxy group at position 3 and ethyl group at position 2 create its distinctive odor profile. Chirality isn’t significant for this particular pyrazine derivative.
Physical & Chemical Properties
| Boiling Point | Not available |
|---|---|
| Density | Not available |
Perfumer Guide
| Application | Typical % | Range | Notes |
|---|---|---|---|
| Fine Fragrance | 0.001-0.01% | Up to 0.05% | Extremely potent – use in ppm ranges |
| Functional Fragrance | 0.0001-0.001% | Up to 0.005% | For green fabric softeners |
Classic Accords
Tip: Always pre-dilute to 0.1% or lower before incorporating into blends.
Alternatives & Comparisons
More intense bell pepper character, used when stronger green notes are desired. Also found naturally in Sauvignon Blanc grapes.
Safety, Regulatory & Sustainability
⚠ Regulatory Disclaimer
General reference only. Consult current IFRA Standards Library before formulating.
IFRA Status
No specific restrictions under current IFRA standards (as of Amendment 49).
RIFM Assessment
RIFM has evaluated similar pyrazines but no specific assessment found for this compound.
Sustainability
As a synthetic material, production avoids agricultural land use but requires petrochemical feedstocks. The extreme potency means minimal quantities are needed per formulation, reducing overall environmental impact compared to less potent naturals.
Explore Pyrazine, 2-ethyl-3-methoxy-
Browse essential oils and aroma compounds.
Browse on iHerb →Affiliate disclosure: we may earn a small commission at no extra cost to you.
References
- Maga, J. A. (1982). Pyrazines in Foods. CRC Critical Reviews in Food Science and Nutrition. DOI:10.1080/10408398209527346
Data: PubChem (NIH), PubMed, RIFM, IFRA. Last reviewed: Apr 2026.
Report a data error
