Quinoline, 5,6,7,8-tetrahydro-8-(1-methylpropyl)- (CAS 1352745-21-1) — Balsamic Base Note Fragrance Ingredient

ByThe Good Scents
Balsamic · Woody

Quinoline, 5,_6,_7,_8-_tetrahydro-_8-_(1-_methylpropyl)_-

CAS 1352745-21-1

Origin
synthetic
Note
Base
IFRA
Professional use
Data as of: Apr 2026

What Is Quinoline, 5,_6,_7,_8-_tetrahydro-_8-_(1-_methylpropyl)_-?

This synthetic ingredient is a specialized quinoline derivative used in niche perfumery. It’s typically found in avant-garde or experimental fragrances. While not common in mainstream products, it offers unique olfactory properties prized by perfumers for creating distinctive scent profiles.

Safety Profile

PROFESSIONAL USE
Generally safeUse with awarenessProfessional use
⚠ Limited safety data available
⚠ Professional handling recommended
CAS
1352745-21-1
Formula
Mixture
MW
Variable
Odor Family
Balsamic · Woody
Layer 1 · Enthusiast

What Does Quinoline, 5,_6,_7,_8-_tetrahydro-_8-_(1-_methylpropyl)_- Smell Like?

This quinoline derivative presents a complex aromatic profile with intense animalic facets reminiscent of leather and tobacco. The opening reveals a sharp, almost medicinal quality that evolves into a warm, musky heart with subtle woody undertones. The dry-down exhibits remarkable tenacity, leaving behind a lingering trail of smoky, slightly ambery notes with a hint of metallic sophistication.

Scent Profile
Layer 2

Chemistry, Properties & Perfumer Guide

The Chemistry

This synthetic quinoline derivative belongs to the heterocyclic aromatic compound class. The tetrahydro modification and isobutyl substitution pattern significantly alter its olfactory properties compared to simple quinolines. While specific synthesis routes are proprietary, it likely involves hydrogenation and alkylation steps starting from quinoline precursors. The stereochemistry at the 8-position may influence its odor characteristics.

Physical & Chemical Properties

Perfumer Guide

Note Position
Base
Volatility
Very low (24+ hours)
Blending
Challenging
ApplicationTypical %RangeNotes
Fine Fragrance0.1-0.5%Up to 1%Used as animalic modifier
Functional FragranceNot usedN/AToo strong for most applications

Classic Accords

Tip: Use sparingly in leather or tobacco bases to add complexity without overwhelming.

Alternatives & Comparisons

1
Isobutyl quinoline CAS 93-19-6

More commonly available quinoline derivative with similar but less complex olfactory profile.

Layer 3

Safety, Regulatory & Sustainability

⚠ Regulatory Disclaimer

General reference only. Consult current IFRA Standards Library before formulating.

IFRA Status

No specific IFRA restrictions. General quinoline guidelines apply.

RIFM Assessment

No RIFM assessment available for this specific compound.

Sustainability

As a synthetic material, this compound’s environmental impact depends on production methods. Being used in trace amounts minimizes its overall footprint. Current supply chains are limited due to specialized nature of production.

Explore Quinoline, 5,_6,_7,_8-_tetrahydro-_8-_(1-_methylpropyl)_-

Browse essential oils and aroma compounds.

Browse on iHerb →

Affiliate disclosure: we may earn a small commission at no extra cost to you.

References

    Data: PubChem (NIH), PubMed, RIFM, IFRA. Last reviewed: Apr 2026.

    Report a data error

    Similar Posts