1-Methyl-2-(1-methylpropyl)cyclohexyl acetate (CAS 72183-75-6) — Woody Base Note Fragrance Ingredient

ByThe Good Scents
Woody · Balsamic

1-Methyl-2-(1-methylpropyl)cyclohexyl acetate

CAS 72183-75-6

Origin
synthetic
Note
Base
IFRA
Generally safe
Data as of: Apr 2026

What Is 1-Methyl-2-(1-methylpropyl)cyclohexyl acetate?

1-Methyl-2-(1-methylpropyl)cyclohexyl acetate is a synthetic fragrance ingredient used to add woody, earthy nuances to perfumes. It’s found in some niche fragrances and personal care products. This molecule helps create depth and longevity in scent compositions, often blending seamlessly with other woody and amber notes.

Safety Profile

GENERALLY SAFE
Generally safeUse with awarenessProfessional use
✓ Safe in regulated products
⚠ Check for skin sensitivity
CAS
72183-75-6
Formula
Mixture
MW
Variable
Odor Family
Woody · Balsamic
Layer 1 · Enthusiast

What Does 1-Methyl-2-(1-methylpropyl)cyclohexyl acetate Smell Like?

This synthetic molecule offers a complex woody profile with subtle earthy undertones. It evolves from a slightly green top note to a warm, musky heart, settling into a dry, ambery base. The scent is reminiscent of aged cedarwood with a whisper of damp forest floor, making it ideal for creating naturalistic woody accords.

Scent Profile
Layer 2

2D Molecular Structure

Cyclohexanol, 1-methyl-2-(1-methylpropyl)-, 1-acetate

SMILES: CCC(C)C1CCCCC1(C)OC(C)=O

Chemistry, Properties & Perfumer Guide

The Chemistry

1-Methyl-2-(1-methylpropyl)cyclohexyl acetate is a synthetic ester derived from modified cyclohexane structures. Its synthesis typically involves esterification of corresponding alcohols with acetic acid derivatives. The branched alkyl groups contribute to its unique stereochemistry and scent profile, making it particularly stable in formulations.

Physical & Chemical Properties

Boiling PointNot available
DensityNot available

Perfumer Guide

Note Position
Base
Volatility
Medium (2-4 hours)
Blending
Good
ApplicationTypical %RangeNotes
Fine Fragrance1-5%Up to 10%Adds woody depth
Personal Care0.5-2%Up to 5%Used for base notes

Classic Accords

Tip: Use to anchor citrus top notes in woody compositions.

Alternatives & Comparisons

1
Vertofix CAS 68039-49-6

A more intense woody alternative with similar stability in formulations.

Layer 3

Safety, Regulatory & Sustainability

⚠ Regulatory Disclaimer

General reference only. Consult current IFRA Standards Library before formulating.

IFRA Status

Not currently restricted by IFRA.

RIFM Assessment

Not currently assessed by RIFM.

Sustainability

As a synthetic material, this ingredient avoids natural resource depletion. Its production can be optimized for minimal environmental impact through green chemistry principles.

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References

    Data: PubChem (NIH), PubMed, RIFM, IFRA. Last reviewed: Apr 2026.

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    Ingredient Data Sheet

    CAS 72183-75-6

    Physical Properties

    Molecular Weight212.33 g/mol🔬 PubChem
    LogP (Octanol-Water)3.9🔬 PubChem
    Boiling Point254 °C🔬 EPA CompTox
    Vapor Pressure0.049 mmHg @ 25°C📊 OPERA
    Flash Point102.4 °C🔬 EPA CompTox
    Involatility Index0.0036💻 Calculated
    log Kp (skin permeability)-1.226💻 Calculated
    SMILESCCC(C)C1CCCCC1(C)OC(=O)C🔬 PubChem

    Volatility & Performance

    Fragrance NoteHeart💻 Calculated
    Volatility ClassVery slow💻 Calculated
    Persistence Score2.8 / 5💻 Calculated

    Odor & Flavor

    Primary Descriptorsbalsamicwoody• leffingwell
    Functional Groupsesterether💻 RDKit
    Data Sources & Attribution
    Physical data: PubChem (NIH/NLM), U.S. EPA CompTox Dashboard, EPA OPERA models, RDKit. Odor & flavor: Arctander (Perfume & Flavor Chemicals), Fenaroli's Handbook of Flavor Ingredients, Leffingwell. Thresholds: van Gemert (Compilations of Odour Threshold Values). Regulatory: IFRA Standards 51st, FEMA GRAS. Trade names: Surburg (Common Fragrance & Flavor Materials). All data compiled and cross-referenced for perfumertools.com.

    Physicochemical Properties

    DTXSID: DTXSID70868098

    Physical Properties

    Molecular Weight 212.333 g/mol🔬 EPA CompTox
    Density 0.917 g/cm^3📊 OPERA
    Boiling Point 241.312 °C📊 OPERA
    Melting Point 4.744 °C📊 OPERA
    Flash Point 95.575 °C📊 OPERA
    Refractive Index 1.453 Dimensionless📊 OPERA
    Molar Volume 229.5 cm^3/mol📊 OPERA

    Partition & Solubility

    LogP (Octanol-Water) 4.463 Log10 unitless📊 OPERA
    LogD (pH 5.5) 4.463 Log10 unitless📊 OPERA
    LogD (pH 7.4) 4.463 Log10 unitless📊 OPERA
    LogKoa (Octanol-Air) 5.97 Log10 unitless📊 OPERA
    Water Solubility 0 mol/L📊 OPERA
    Henry's Law Constant 0 atm-m3/mole📊 OPERA

    Transport Properties

    Vapor Pressure 0.044 mmHg📊 OPERA
    Viscosity 4.1 cP📊 OPERA
    Surface Tension 29.782 dyn/cm📊 OPERA
    Thermal Conductivity 126.06 mW/(m*K)📊 OPERA

    Molecular Descriptors

    Topological Polar Surface Area 26.3 Ų💻 Computed
    H-Bond Donors 0 count💻 Computed
    H-Bond Acceptors 2 count💻 Computed
    Rotatable Bonds 3 count💻 Computed
    Aromatic Rings 0 count💻 Computed
    Molar Refractivity 62.011 cm^3/mol📊 OPERA
    Polarizability 24.583 Å^3📊 OPERA

    Data Sources:

    🔬 EPA Experimental data from U.S. EPA CompTox Chemicals Dashboard & CTX APIs. 📊 OPERA Predicted using EPA's OPERA QSAR models. 💻 Computed Calculated from SMILES using RDKit.

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