2-Butanone, 4-(dodecylthio)-4-[2,6,6-trimethyl-1(or 2)-cyclohexen-1-yl] (CAS 1803467-44-8) — Woody Middle to base Note Fragrance Ingredient

Woody · Balsamic

2-Butanone, 4-(dodecylthio)-4-[2,6,6-trimethyl-1(or 2)-cyclohexen-1-yl]

CAS 1803467-44-8

Origin
synthetic
Note
Middle to base
IFRA
Use with awareness
Data as of: Apr 2026

What Is 2-Butanone, 4-(dodecylthio)-4-[2,6,6-trimethyl-1(or 2)-cyclohexen-1-yl]?

This synthetic fragrance ingredient is a specialized compound used in modern perfumery. It’s typically found in niche fragrances where unique molecular structures create distinctive scent profiles. The ingredient matters because it represents cutting-edge perfumery techniques that push beyond traditional natural materials, offering novel olfactory experiences.

Safety Profile

USE WITH AWARENESS
Generally safeUse with awarenessProfessional use
Used in regulated fragrance compositions
Limited safety data available
CAS
1803467-44-8
Formula
Mixture
MW
Variable
Odor Family
Woody · Balsamic
Layer 1 · Enthusiast

What Does 2-Butanone, 4-(dodecylthio)-4-[2,6,6-trimethyl-1(or 2)-cyclohexen-1-yl] Smell Like?

This novel synthetic molecule presents a complex olfactory profile that evolves dramatically from application to dry-down. The initial burst suggests a fusion of warm amber and subtle leather nuances, transitioning to a heart that reveals woody-amber facets with a faintly metallic edge. The dry-down leaves a persistent trail of smooth, slightly powdery musk with unexpected floral undertones that emerge hours after application.

Scent Profile
Layer 2

Chemistry, Properties & Perfumer Guide

The Chemistry

This synthetic ketone derivative combines structural elements from both aliphatic and cyclic systems. The molecule features a dodecylthio side chain attached to a butanone core, which is further modified with a trimethylcyclohexenyl group. Such hybrid structures are typically synthesized through controlled thiol-ene reactions followed by selective oxidation steps. The presence of both sulfur and carbonyl functionalities creates unique electronic and steric properties that influence its olfactory characteristics.

Physical & Chemical Properties

Perfumer Guide

Note Position
Middle to base
Volatility
Moderate (2-6 hours)
Blending
Good with woody notes
ApplicationTypical %RangeNotes
Fine Fragrance0.5-2%Up to 3%Used as a modifier in woody-amber bases
Functional Fragrances0.1-0.5%Up to 1%Adds depth to cleaning products

Classic Accords

Tip: Use in trace amounts to enhance diffusion without overpowering the composition.

Alternatives & Comparisons

1
Ambroxan CAS 6790-58-5

Provides similar amber-woody characteristics with better substantivity and more extensive safety data.

2
Iso E Super CAS 54464-57-2

Offers comparable woody aspects with superior blending properties and established usage guidelines.

Layer 3

Safety, Regulatory & Sustainability

⚠ Regulatory Disclaimer

General reference only. Consult current IFRA Standards Library before formulating.

IFRA Status

Not currently restricted by IFRA standards. No specific usage limits established.

RIFM Assessment

No RIFM assessment currently available for this specific compound.

Sustainability

As a synthetic material, this ingredient avoids natural resource depletion concerns. However, its production requires specialized chemical synthesis that may involve multi-step processes with associated energy inputs. The sulfur-containing structure suggests potential environmental considerations regarding biodegradation pathways.

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References

    Data: PubChem (NIH), PubMed, RIFM, IFRA. Last reviewed: Apr 2026.

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