2-Ethoxy-3-Isopropylpyrazine (CAS 72797-16-1) — Mid Note Fragrance Ingredient

ByThe Good Scents



terpenic

2-Ethoxy-3-Isopropylpyrazine

CAS 72797-16-1

Note
mid
Volatility
medium
MW
166.2
Data as of: Jun 2026

What Is 2-Ethoxy-3-Isopropylpyrazine?

2-Ethoxy-3-Isopropylpyrazine (CAS 72797-16-1) is an aroma chemical used as a fragrance and flavour ingredient. Its odour is described as pea, earthy and nutty, placing it within the terpenic family as a mid note with medium volatility. With a molecular weight of 166.2 (formula C9H14N2O), it is handled by perfumers as a building block for compositions where a pea character is desired. The data below is compiled from public chemical and regulatory sources.

Safety Profile

USE WITH AWARENESS

Generally safeUse with awarenessProfessional use
CAS
72797-16-1
Formula
C9H14N2O
MW
166.2
InChIKey
LTAUBPVQMBOANV-UHFFFAOYSA-N
2-Ethoxy-3-Isopropylpyrazine 2D structure

2-Ethoxy-3-Isopropylpyrazine
C9H14N2O
Layer 1 · Enthusiast

What Does 2-Ethoxy-3-Isopropylpyrazine Smell Like?

The odour profile of 2-Ethoxy-3-Isopropylpyrazine is reported as pea, earthy, nutty, green, galbanum, bell, pepper. The dominant facet is its pea character, with the remaining notes adding nuance and complexity. As a mid note it contributes to the heart of a fragrance. Perceived intensity and exact character depend on concentration, the carrier and the surrounding accord.

Scent Profile

Profile derived from public odour-descriptor data; relative, not absolute.

Layer 2

Chemistry & Properties

The Chemistry

2-Ethoxy-3-Isopropylpyrazine has the molecular formula C9H14N2O and a molecular weight of 166.2 g/mol. Its canonical SMILES representation is CCOC1=C(N=CC=N1)C(C)C. Its reported log P (XLogP) of 2.00 indicates a moderately polar molecule, which informs how it partitions in a formula. Physical constants below are drawn from PubChem and EPA CompTox public datasets.

Physical & Chemical Properties

Molecular Weight 166.2 g/mol
Boiling Point 214.1 °C
Melting Point 34.39 °C
Flash Point 85.17 °C
Density 0.7833 g/cm³
Vapor Pressure 0.03715 mmHg
Water Solubility 0.032 g/L
XLogP 2.00

Perfumer Guide

Note Position
Mid
Volatility
Medium
Primary Odour
Pea

Alternatives & Comparisons

Ingredients occupying a similar odour space — useful as substitutes or companions when 2-Ethoxy-3-Isopropylpyrazine is unavailable or restricted.

1
2-Methoxy-3-(1-Methylpropyl)Pyrazine CAS 24168-70-5

Shares musty, green, pea character — a candidate substitute or companion in the same odour space.

2
2-Isobutyl-3-methylpyrazine CAS 13925-06-9

Shares earthy, green, nutty character — a candidate substitute or companion in the same odour space.

3
4,5-Dimethyl-2-Isobutylthiazole CAS 53498-32-1

Shares earthy, green, nutty character — a candidate substitute or companion in the same odour space.

Layer 3

Safety & Regulatory

⚠ Regulatory Disclaimer

General reference only. IFRA, REACH and EU Cosmetics Regulation standards update periodically. Consult the current IFRA Standards Library before formulating. Not legal or regulatory advice.

IFRA Status

No IFRA restriction recorded in the data set. This is not a guarantee of unrestricted status — always confirm against the current IFRA Standards Library.

GHS Classification

Signal word: Danger

H302H315H318H335
Formulating with 2-Ethoxy-3-Isopropylpyrazine?

Open 2-Ethoxy-3-Isopropylpyrazine in Fragrance Studio (Pro) for the calibrated vapour-pressure curve, the modelled odour-threshold estimate, and the substitute-matching engine across 2,900+ aromachemicals.

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References & Sources

  1. PubChem Compound Summary (NIH) — search by InChIKey
  2. EPA CompTox Chemicals Dashboard — physicochemical & fate data
  3. IFRA Standards Library (49th / 51st Amendment)
Sources: PubChem (NIH) · EPA CompTox · IFRA Standards Library · public GHS classification. Odour descriptors are original editorial summaries of public profiles, not reproduced from any single proprietary source.

Data: PubChem (NIH), EPA CompTox, IFRA. Last reviewed: Jun 2026.

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