(4-Ethylbicyclo[2.2.1]hept-2-yl)-cyclohexanol (CAS 92046-48-5) — Woody Base Note Fragrance Ingredient

ByThe Good Scents
Woody · Balsamic

(4-Ethylbicyclo[2.2.1]hept-2-yl)-cyclohexanol

CAS 92046-48-5

Origin
synthetic
Note
Base
IFRA
Use with awareness
Data as of: Apr 2026

What Is (4-Ethylbicyclo[2.2.1]hept-2-yl)-cyclohexanol?

(4-Ethylbicyclo[2.2.1]hept-2-yl)-cyclohexanol is a synthetic fragrance ingredient used in modern perfumery. It contributes woody-ambery notes to fragrances, often found in masculine and unisex scents. This molecule matters because it provides long-lasting woody depth without being overpowering, making it valuable for creating balanced, sophisticated accords.

Safety Profile

USE WITH AWARENESS
Generally safeUse with awarenessProfessional use
✓ IFRA compliant
⚠ Potential skin sensitizer at high concentrations
CAS
92046-48-5
Formula
Mixture
MW
Variable
Odor Family
Woody · Balsamic
Layer 1 · Enthusiast

What Does (4-Ethylbicyclo[2.2.1]hept-2-yl)-cyclohexanol Smell Like?

This molecule presents a complex woody-ambergris character with subtle earthy undertones. Initially, it offers a crisp, slightly camphoraceous top note that evolves into a warm, ambery heart. The dry-down reveals a sophisticated woody-balsamic signature reminiscent of aged cedarwood with a whisper of musk. Its tenacity allows it to act as a subtle fixative, blending seamlessly with both floral and oriental compositions.

Scent Profile
Layer 2

2D Molecular Structure

1-(4-Ethylbicyclo[2.2.1]heptan-2-yl)cyclohexan-1-ol

SMILES: CCC12CCC(C1)C(C2)C1(O)CCCCC1

Chemistry, Properties & Perfumer Guide

The Chemistry

(4-Ethylbicyclo[2.2.1]hept-2-yl)-cyclohexanol belongs to the bicyclic terpenoid alcohol class, synthesized through hydrogenation of terpene derivatives. Its unique structure combines cyclohexanol with an ethyl-substituted norbornane moiety, creating a stable molecular framework. The synthesis typically involves catalytic hydrogenation of suitable terpene precursors under controlled conditions to achieve the desired stereochemistry.

Physical & Chemical Properties

Perfumer Guide

Note Position
Base
Volatility
Low (6+ hours)
Blending
Good
ApplicationTypical %RangeNotes
Fine Fragrance1-3%Up to 5%Woody-amber base note
Functional Fragrance0.5-1.5%Up to 2%Long-lasting woody character

Classic Accords

Tip: Use as a supporting note to enhance woody accords without dominating the composition.

Alternatives & Comparisons

1
Ambroxan CAS 6790-58-5

Provides similar ambery-woody effects with greater diffusion and less earthy character.

2
Norlimbanol CAS 70788-30-6

Offers more pronounced woody-dry effects with excellent tenacity.

Layer 3

Safety, Regulatory & Sustainability

⚠ Regulatory Disclaimer

General reference only. Consult current IFRA Standards Library before formulating.

IFRA Status

No specific IFRA restrictions. Compliant under current guidelines.

RIFM Assessment

Not currently evaluated by RIFM. Recommended usage levels based on structural analogs.

Sustainability

As a synthetic ingredient, this molecule offers consistent quality without natural resource depletion. Production can be optimized for minimal environmental impact through green chemistry principles. Being petroleum-derived, its sustainability depends on responsible sourcing of feedstocks.

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References

    Data: PubChem (NIH), PubMed, RIFM, IFRA. Last reviewed: Apr 2026.

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    Ingredient Data Sheet

    CAS 92046-48-5

    Physical Properties

    Molecular Weight222.37 g/mol🔬 PubChem
    LogP (Octanol-Water)4.4🔬 PubChem
    Boiling Point283 °C🔬 EPA CompTox
    Vapor Pressure0.0071 mmHg @ 25°C📊 OPERA
    Flash Point130.8 °C🔬 EPA CompTox
    Involatility Index0.0005💻 Calculated
    log Kp (skin permeability)-0.932💻 Calculated
    SMILESCCC12CCC(C1)C(C2)C3(CCCCC3)O🔬 PubChem

    Volatility & Performance

    Fragrance NoteBase💻 Calculated
    Volatility ClassVery slow💻 Calculated
    Persistence Score4.9 / 5💻 Calculated

    Odor & Flavor

    Primary Descriptorsbalsamicwoody• leffingwell
    Functional Groupsalcohol💻 RDKit
    Data Sources & Attribution
    Physical data: PubChem (NIH/NLM), U.S. EPA CompTox Dashboard, EPA OPERA models, RDKit. Odor & flavor: Arctander (Perfume & Flavor Chemicals), Fenaroli's Handbook of Flavor Ingredients, Leffingwell. Thresholds: van Gemert (Compilations of Odour Threshold Values). Regulatory: IFRA Standards 51st, FEMA GRAS. Trade names: Surburg (Common Fragrance & Flavor Materials). All data compiled and cross-referenced for perfumertools.com.

    Physicochemical Properties

    DTXSID: DTXSID10869089

    Physical Properties

    Molecular Weight 222.372 g/mol🔬 EPA CompTox
    Density 1.021 g/cm^3📊 OPERA
    Boiling Point 296.666 °C📊 OPERA
    Melting Point 109.942 °C📊 OPERA
    Flash Point 139.07 °C📊 OPERA
    Refractive Index 1.539 Dimensionless📊 OPERA
    Molar Volume 213.065 cm^3/mol📊 OPERA

    Partition & Solubility

    LogP (Octanol-Water) 4.19 Log10 unitless📊 OPERA
    LogD (pH 5.5) 4.19 Log10 unitless📊 OPERA
    LogD (pH 7.4) 4.19 Log10 unitless📊 OPERA
    LogKoa (Octanol-Air) 8.47 Log10 unitless📊 OPERA
    Water Solubility 0.001 mol/L📊 OPERA
    Henry's Law Constant 0 atm-m3/mole📊 OPERA

    Transport Properties

    Vapor Pressure 0.003 mmHg📊 OPERA
    Viscosity 28.124 cP📊 OPERA
    Surface Tension 39.936 dyn/cm📊 OPERA
    Thermal Conductivity 128.009 mW/(m*K)📊 OPERA

    Molecular Descriptors

    Topological Polar Surface Area 20.23 Ų💻 Computed
    H-Bond Donors 1 count💻 Computed
    H-Bond Acceptors 1 count💻 Computed
    Rotatable Bonds 2 count💻 Computed
    Aromatic Rings 0 count💻 Computed
    Molar Refractivity 66.772 cm^3/mol📊 OPERA
    Polarizability 26.47 Å^3📊 OPERA

    Data Sources:

    🔬 EPA Experimental data from U.S. EPA CompTox Chemicals Dashboard & CTX APIs. 📊 OPERA Predicted using EPA's OPERA QSAR models. 💻 Computed Calculated from SMILES using RDKit.

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