8-Cyclohexadecen-1-one, (8E) (CAS 5365-06-0) — Musky Base Note Fragrance Ingredient
8-Cyclohexadecen-1-one, (8E)
CAS 5365-06-0
What Is 8-Cyclohexadecen-1-one, (8E)?
8-Cyclohexadecen-1-one is a synthetic musk compound used in modern perfumery. It contributes to the long-lasting base notes of many luxury fragrances. This ingredient matters because it provides a clean, musky foundation that enhances other scent components without being overpowering.
Safety Profile
GENERALLY SAFEWhat Does 8-Cyclohexadecen-1-one, (8E) Smell Like?
8-Cyclohexadecen-1-one offers a refined musky character with subtle woody undertones. Unlike animalic musks, it presents as clean and slightly powdery, evolving into a soft skin-like scent during dry-down. The (8E) isomer provides a particularly smooth diffusion, making it ideal for modern fragrance bases where a non-intrusive musk is desired.
Chemistry, Properties & Perfumer Guide
The Chemistry
8-Cyclohexadecen-1-one belongs to the macrocyclic ketone class of musks. As a synthetic compound, it’s typically produced through ring-closing metathesis or other cyclization techniques. The (8E) configuration refers to the trans double bond position, which influences its odor profile and stability in formulations.
Physical & Chemical Properties
Perfumer Guide
| Application | Typical % | Range | Notes |
|---|---|---|---|
| Fine Fragrance | 1-3% | Up to 5% | Base note musk component |
| Functional Fragrance | 0.5-1% | Up to 2% | Subtle musk background |
Classic Accords
Tip: Use to soften harsh woody notes while adding subtle musk complexity.
Alternatives & Comparisons
More affordable macrocyclic musk with similar clean character but slightly sweeter profile.
Safety, Regulatory & Sustainability
⚠ Regulatory Disclaimer
General reference only. Consult current IFRA Standards Library before formulating.
IFRA Status
No IFRA restrictions currently apply.
RIFM Assessment
Considered safe for current use levels based on RIFM evaluation.
Sustainability
As a synthetic ingredient, 8-Cyclohexadecen-1-one avoids the ecological concerns associated with animal-derived musks. Its production typically involves controlled chemical processes with efficient resource use. Being petroleum-derived, its environmental impact depends on the sustainability practices of the manufacturing facility.
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