Isocyclocitral (CAS 67634-07-5) — Mid Note Fragrance Ingredient

ByThe Good Scents



sharp leafy green

Isocyclocitral

CAS 67634-07-5

Note
mid
Volatility
high
MW
304.5
Data as of: Jun 2026

What Is Isocyclocitral?

Isocyclocitral (CAS 67634-07-5) is an aroma chemical used as a fragrance and flavour ingredient. Its odour is described as sharp leafy, green and floral, placing it as a mid note with high volatility. With a molecular weight of 304.5 (formula C20H32O2), it is handled by perfumers as a building block for compositions where a sharp leafy character is desired. The data below is compiled from public chemical and regulatory sources.

Safety Profile

USE WITH AWARENESS

Generally safeUse with awarenessProfessional use
CAS
67634-07-5
Formula
C20H32O2
MW
304.5
InChIKey
AEXLFXYEFLKADK-UHFFFAOYSA-N
Isocyclocitral 2D structure

Isocyclocitral
C20H32O2
Layer 1 · Enthusiast

What Does Isocyclocitral Smell Like?

The odour profile of Isocyclocitral is reported as sharp leafy, green, floral, flower shop, aldehydic, earthy, crushed stems, fresh. The dominant facet is its sharp leafy character, with the remaining notes adding nuance and complexity. As a mid note it contributes to the heart of a fragrance. Perceived intensity and exact character depend on concentration, the carrier and the surrounding accord.

Scent Profile

Profile derived from public odour-descriptor data; relative, not absolute.

Layer 2

Chemistry & Properties

The Chemistry

Isocyclocitral has the molecular formula C20H32O2 and a molecular weight of 304.5 g/mol. Its canonical SMILES representation is CC1CC(=CC(C1C=O)C)C.CC1C=C(CC(C1C)C=O)C. Its reported log P (XLogP) of 4.85 indicates a lipophilic, oil-soluble molecule, which informs how it partitions in a formula. Physical constants below are drawn from PubChem and EPA CompTox public datasets.

Physical & Chemical Properties

Molecular Weight 304.5 g/mol
Boiling Point 211.2 °C
Melting Point -2.69 °C
Flash Point 65.75 °C
Density 0.9035 g/cm³
Vapor Pressure 0.291 mmHg
Water Solubility 0.00537 g/L
XLogP 4.85

Perfumer Guide

Note Position
Mid
Volatility
High
Primary Odour
Sharp Leafy

Alternatives & Comparisons

Ingredients occupying a similar odour space — useful as substitutes or companions when Isocyclocitral is unavailable or restricted.

1
1-ethoxyethoxycyclododecane CAS 389083-83-4

Shares earthy, floral, fresh character — a candidate substitute or companion in the same odour space.

2
(5E)-6,10-dimethylundeca-5,9-dien-2-one CAS 689-67-8

Shares aldehydic, floral, fresh character — a candidate substitute or companion in the same odour space.

3
1-Cyclohexene-1-propanal, 4-(1-methylethyl)-, (4R) CAS 1378867-81-2

Shares green, woody, aldehydic character — a candidate substitute or companion in the same odour space.

Layer 3

Safety & Regulatory

⚠ Regulatory Disclaimer

General reference only. IFRA, REACH and EU Cosmetics Regulation standards update periodically. Consult the current IFRA Standards Library before formulating. Not legal or regulatory advice.

IFRA Status

Subject to an IFRA restriction (51st Amendment) — maximum use levels apply by product category. Consult the current IFRA Standards Library before formulating.

GHS Classification

Signal word: Warning

H317

Odour detection threshold (air): 0.00038 ppb — a literature-curated value indicating its potency in the vapour phase.

Formulating with Isocyclocitral?

Open Isocyclocitral in Fragrance Studio (Pro) for the calibrated vapour-pressure curve, the modelled odour-threshold estimate, and the substitute-matching engine across 2,900+ aromachemicals.

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References & Sources

  1. PubChem Compound Summary (NIH) — search by InChIKey
  2. EPA CompTox Chemicals Dashboard — physicochemical & fate data
  3. IFRA Standards Library (49th / 51st Amendment)
Sources: PubChem (NIH) · EPA CompTox · IFRA Standards Library · public GHS classification. Odour descriptors are original editorial summaries of public profiles, not reproduced from any single proprietary source.

Data: PubChem (NIH), EPA CompTox, IFRA. Last reviewed: Jun 2026.

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