Methyl Isopentyl Disulfide (CAS 72437-56-0) — Top Note Fragrance Ingredient

ByThe Good Scents



terpenic

Methyl Isopentyl Disulfide

CAS 72437-56-0

Note
top
Volatility
high
MW
150.3
Data as of: Jun 2026

What Is Methyl Isopentyl Disulfide?

Methyl Isopentyl Disulfide (CAS 72437-56-0) is an aroma chemical used as a fragrance and flavour ingredient. Its odour is described as bakery, sweet and fish, placing it within the terpenic family as a top note with high volatility. With a molecular weight of 150.3 (formula C6H14S2), it is handled by perfumers as a building block for compositions where a bakery character is desired. The data below is compiled from public chemical and regulatory sources.

Safety Profile

HANDLE WITH CARE

Generally safeUse with awarenessProfessional use
CAS
72437-56-0
Formula
C6H14S2
MW
150.3
InChIKey
XTTOMWDBKHINLK-UHFFFAOYSA-N
Methyl Isopentyl Disulfide 2D structure

Methyl Isopentyl Disulfide
C6H14S2
Layer 1 · Enthusiast

What Does Methyl Isopentyl Disulfide Smell Like?

The odour profile of Methyl Isopentyl Disulfide is reported as bakery, sweet, fish, garlic, spices, cold, sour, burnt, acid, warm, musky, sweaty, ammonia/urinous, decayed, wood, grass, chemical, edible. The dominant facet is its bakery character, with the remaining notes adding nuance and complexity. As a top note it contributes to the opening of a fragrance. Perceived intensity and exact character depend on concentration, the carrier and the surrounding accord.

Scent Profile

Profile derived from public odour-descriptor data; relative, not absolute.

Layer 2

Chemistry & Properties

The Chemistry

Methyl Isopentyl Disulfide has the molecular formula C6H14S2 and a molecular weight of 150.3 g/mol. Its canonical SMILES representation is CSSCCC(C)C. Its reported log P (XLogP) of 3.04 indicates a lipophilic, oil-soluble molecule, which informs how it partitions in a formula. Physical constants below are drawn from PubChem and EPA CompTox public datasets.

Physical & Chemical Properties

Molecular Weight 150.3 g/mol
Boiling Point 187.4 °C
Melting Point -17.57 °C
Flash Point 60.16 °C
Density 0.9455 g/cm³
Vapor Pressure 0.9772 mmHg
Water Solubility 0.01198 g/L
XLogP 3.04

Perfumer Guide

Note Position
Top
Volatility
High
Primary Odour
Bakery

Alternatives & Comparisons

Ingredients occupying a similar odour space — useful as substitutes or companions when Methyl Isopentyl Disulfide is unavailable or restricted.

1
2-Methyl-1-Propanethiol CAS 513-44-0

Shares bakery, sweet, fish character — a candidate substitute or companion in the same odour space.

2
Diisoamyl Disulfide CAS 2051-04-9

Shares bakery, sweet, fish character — a candidate substitute or companion in the same odour space.

3
Isoamyl Isothiocyanate CAS 628-03-5

Shares bakery, sweet, fish character — a candidate substitute or companion in the same odour space.

Layer 3

Safety & Regulatory

⚠ Regulatory Disclaimer

General reference only. IFRA, REACH and EU Cosmetics Regulation standards update periodically. Consult the current IFRA Standards Library before formulating. Not legal or regulatory advice.

IFRA Status

No IFRA restriction recorded in the data set. This is not a guarantee of unrestricted status — always confirm against the current IFRA Standards Library.

GHS Classification

Signal word: Warning

H226H302
Formulating with Methyl Isopentyl Disulfide?

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References & Sources

  1. PubChem Compound Summary (NIH) — search by InChIKey
  2. EPA CompTox Chemicals Dashboard — physicochemical & fate data
  3. IFRA Standards Library (49th / 51st Amendment)
Sources: PubChem (NIH) · EPA CompTox · IFRA Standards Library · public GHS classification. Odour descriptors are original editorial summaries of public profiles, not reproduced from any single proprietary source.

Data: PubChem (NIH), EPA CompTox, IFRA. Last reviewed: Jun 2026.

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