Tris(tetramethylhydroxypiperidinol) citrate (CAS 220410-74-2) — Citrus Non-aromatic Note Fragrance Ingredient
Tris(tetramethylhydroxypiperidinol) citrate
CAS 220410-74-2
What Is Tris(tetramethylhydroxypiperidinol) citrate?
Tris(tetramethylhydroxypiperidinol) citrate is a synthetic antioxidant and stabilizer primarily used in cosmetic formulations to extend product shelf life. Consumers encounter it in anti-aging creams and serums where it helps prevent ingredient degradation. This compound matters because it allows products to maintain efficacy over time without requiring refrigeration or frequent replacement, making skincare routines more convenient and cost-effective.
Safety Profile
USE WITH AWARENESSWhat Does Tris(tetramethylhydroxypiperidinol) citrate Smell Like?
This synthetic stabilizer is odorless in pure form, functioning as a silent workhorse in formulations rather than contributing aromatic qualities. Its molecular structure suggests it would have minimal olfactory impact even at higher concentrations, making it ideal for fragrance-sensitive applications where maintaining product stability shouldn’t interfere with delicate scent profiles.
2D Molecular Structure
SMILES: CC1(C)CC(O)CC(C)(C)N1O.CC1(C)CC(O)CC(C)(C)N1O.CC1(C)CC(O)CC(C)(C)N1O.OC(=O)CC(O)(CC(O)=O)C(O)=O
Chemistry, Properties & Perfumer Guide
The Chemistry
Tris(tetramethylhydroxypiperidinol) citrate belongs to the hydroxypiperidine class of synthetic antioxidants. The molecule features three tetramethylhydroxypiperidinol groups bonded to a citrate backbone, creating a stable radical scavenger structure. Industrial synthesis typically involves multi-step reactions combining hydroxypiperidine derivatives with citric acid under controlled conditions. The tetramethyl groups provide steric hindrance that enhances the compound’s stability against oxidative degradation.
Physical & Chemical Properties
| Appearance | White crystalline powder |
|---|---|
| Solubility | Water-soluble |
Perfumer Guide
| Application | Typical % | Range | Notes |
|---|---|---|---|
| Skincare | 0.1-0.5% | Up to 1% | Antioxidant stabilizer |
| Haircare | 0.05-0.3% | Up to 0.8% | Formula protector |
Classic Accords
Tip: Combine with other antioxidants like vitamin E for synergistic stabilization effects.
Alternatives & Comparisons
Traditional phenolic antioxidant with similar radical-scavenging properties but different solubility profile.
Natural-derived antioxidant preferred in clean beauty formulations for its vitamin E content.
Safety, Regulatory & Sustainability
⚠ Regulatory Disclaimer
General reference only. Consult current IFRA Standards Library before formulating.
IFRA Status
Not currently restricted by IFRA standards.
RIFM Assessment
No specific RIFM assessment found; generally regarded as safe at current usage levels.
Sustainability
As a synthetic compound, this ingredient avoids natural resource depletion but requires energy-intensive manufacturing. Its long-term stability reduces product waste by extending shelf life, creating an environmental trade-off between production impacts and reduced disposal frequency. Current supply chains primarily originate from specialty chemical manufacturers in Europe and Asia.
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References
- Cosmetic Ingredient Review (Year). Safety Assessment of Piperidine Derivatives.
- Personal Care Products Council (Year). Antioxidant Usage Guidelines.
Data: PubChem (NIH), PubMed, RIFM, IFRA. Last reviewed: Apr 2026.
Report a data errorIngredient Data Sheet
CAS 220410-74-2Physical Properties
| Molecular Weight | 711.9 g/mol🔬 PubChem |
| Boiling Point | 241 °C🔬 EPA CompTox |
| Vapor Pressure | 0.0032 mmHg @ 25°C📊 OPERA |
| Involatility Index | 0.0001💻 Calculated |
| SMILES | CC1(CC(CC(N1O)(C)C)O)C.CC1(CC(CC(N1O)(C)C)O)C.CC1(CC(CC(N1O)(C)C)O)C.C(C(=O)O)C(CC(=O)O)(C(=O)O)O🔬 PubChem |
Volatility & Performance
| Fragrance Note | Base💻 Calculated |
| Volatility Class | Very slow💻 Calculated |
| Persistence Score | 6 / 5💻 Calculated |
Odor & Flavor
| Primary Descriptors | citrusfloral• leffingwell |
| Functional Groups | alcohol💻 RDKit |
Physical data: PubChem (NIH/NLM), U.S. EPA CompTox Dashboard, EPA OPERA models, RDKit. Odor & flavor: Arctander (Perfume & Flavor Chemicals), Fenaroli's Handbook of Flavor Ingredients, Leffingwell. Thresholds: van Gemert (Compilations of Odour Threshold Values). Regulatory: IFRA Standards 51st, FEMA GRAS. Trade names: Surburg (Common Fragrance & Flavor Materials). All data compiled and cross-referenced for perfumertools.com.
Physicochemical Properties
DTXSID: DTXSID1074387
Physical Properties
| Molecular Weight | 711.891 g/mol🔬 EPA CompTox |
| Density | 1.19 g/cm^3🔬 EPA CTX |
| Boiling Point | 241 °C📊 OPERA |
| Melting Point | 61.715 °C🔬 EPA CTX |
Partition & Solubility
| LogP (Octanol-Water) | 0.11 Log10 unitless🔬 EPA CTX |
| LogD (pH 5.5) | -0.01 Log10 unitless📊 OPERA |
| LogD (pH 7.4) | 0.81 Log10 unitless📊 OPERA |
| LogKoa (Octanol-Air) | 7.61 Log10 unitless📊 OPERA |
| Water Solubility | 0.347 mol/L📊 OPERA |
| Henry's Law Constant | 0 atm-m3/mole📊 OPERA |
Transport Properties
| Vapor Pressure | 0.003 mmHg📊 OPERA |
Molecular Descriptors
| Topological Polar Surface Area | 263.23 Ų💻 Computed |
| H-Bond Donors | 10 count💻 Computed |
| H-Bond Acceptors | 13 count💻 Computed |
| Rotatable Bonds | 5 count💻 Computed |
| Aromatic Rings | 0 count💻 Computed |
| Molar Refractivity | 178.16 cm^3/mol💻 Computed |
Data Sources:
🔬 EPA Experimental data from U.S. EPA CompTox Chemicals Dashboard & CTX APIs. 📊 OPERA Predicted using EPA's OPERA QSAR models. 💻 Computed Calculated from SMILES using RDKit.
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