5-Hydroxy-2,4-decadienoic acid delta-lactone (CAS 27593-23-3) — Sweet Middle Note Fragrance Ingredient

ByThe Good Scents
Sweet · Balsamic

5-Hydroxy-2,4-decadienoic acid delta-lactone

CAS 27593-23-3

Origin
synthetic
Note
Middle
IFRA
Generally safe
Data as of: Apr 2026

What Is 5-Hydroxy-2,4-decadienoic acid delta-lactone?

5-Hydroxy-2,4-decadienoic acid delta-lactone is a synthetic fragrance compound primarily used in perfumery. It’s not commonly encountered in everyday products but plays a specialized role in creating certain scent profiles. This lactone contributes unique olfactory characteristics that are valued by perfumers for adding depth and complexity to fragrance compositions.

Safety Profile

GENERALLY SAFE
Generally safeUse with awarenessProfessional use
✓ No major safety concerns reported
⚠ Limited toxicological data available
CAS
27593-23-3
Formula
Mixture
MW
Variable
Odor Family
Sweet · Balsamic
Layer 1 · Enthusiast

What Does 5-Hydroxy-2,4-decadienoic acid delta-lactone Smell Like?

This lactone delivers a rich, fatty character with subtle fruity undertones. The scent evolves from an initial waxy, slightly animalic impression to reveal deeper buttery nuances. In dry-down, it contributes a creamy, lactonic quality reminiscent of ripe peaches or coconut flesh. The molecule’s structure gives it excellent tenacity, allowing its smooth, fatty notes to persist through the heart phase of a fragrance.

Scent Profile
Layer 2

2D Molecular Structure

6-Amyl-alpha-pyrone

SMILES: CCCCCC1=CC=CC(=O)O1

Chemistry, Properties & Perfumer Guide

The Chemistry

5-Hydroxy-2,4-decadienoic acid delta-lactone belongs to the class of unsaturated lactones. While not found in nature, it’s synthesized through controlled oxidation processes of fatty acids. The molecule’s delta-lactone ring structure contributes to its stability and distinctive odor profile. Its unsaturated carbon chain allows for interesting interactions with other fragrance components.

Physical & Chemical Properties

Molecular TypeSynthetic lactone

Perfumer Guide

Note Position
Middle
Volatility
Medium (2-4 hours)
Blending
Good
ApplicationTypical %RangeNotes
Fine Fragrance0.5-2%Up to 5%Used as a modifier for fruity or creamy accords
Functional Fragrance0.1-0.5%Up to 1%Adds depth to household product scents

Classic Accords

Tip: Use sparingly in fruity compositions to add naturalistic fatty undertones.

Alternatives & Comparisons

1
Gamma-Decalactone CAS 706-14-9

For a more pronounced peach character with similar lactonic properties.

2
Delta-Dodecalactone CAS 713-95-1

When a longer-lasting, more coconut-like lactonic effect is desired.

Layer 3

Safety, Regulatory & Sustainability

⚠ Regulatory Disclaimer

General reference only. Consult current IFRA Standards Library before formulating.

IFRA Status

Not currently restricted by IFRA standards.

RIFM Assessment

Limited safety assessment data available through RIFM.

Sustainability

As a synthetic material, this lactone’s environmental impact is primarily related to its manufacturing process. Being produced in controlled laboratory settings allows for precise quality control and reduced ecological footprint compared to some natural alternatives. The compound’s efficiency in formulations means it’s typically used at low concentrations.

Explore 5-Hydroxy-2,4-decadienoic acid delta-lactone

Browse essential oils and aroma compounds.

Browse on iHerb →

Affiliate disclosure: we may earn a small commission at no extra cost to you.

References

    Data: PubChem (NIH), PubMed, RIFM, IFRA. Last reviewed: Apr 2026.

    Report a data error

    Ingredient Data Sheet

    CAS 27593-23-3

    Physical Properties

    Molecular Weight166.22 g/mol🔬 PubChem
    LogP (Octanol-Water)3🔬 PubChem
    Boiling Point285 °C🔬 EPA CompTox
    log Kp (skin permeability)-1.584💻 Calculated
    SMILESCCCCCC1=CC=CC(=O)O1🔬 PubChem

    Volatility & Performance

    Fragrance NoteBase💻 Calculated

    Odor & Flavor

    Primary Descriptorsbutterycoconutcreamypeach• leffingwell
    Functional Groupsaromatic💻 RDKit

    Sensory Thresholds

    Odor Detection Threshold0.15 ppm📖 van Gemert
    Data Sources & Attribution
    Physical data: PubChem (NIH/NLM), U.S. EPA CompTox Dashboard, EPA OPERA models, RDKit. Odor & flavor: Arctander (Perfume & Flavor Chemicals), Fenaroli's Handbook of Flavor Ingredients, Leffingwell. Thresholds: van Gemert (Compilations of Odour Threshold Values). Regulatory: IFRA Standards 51st, FEMA GRAS. Trade names: Surburg (Common Fragrance & Flavor Materials). All data compiled and cross-referenced for perfumertools.com.

    Physicochemical Properties

    DTXSID: DTXSID0047589

    Physical Properties

    Molecular Weight 166.22 g/mol🔬 EPA CompTox
    Density 1.005 g/cm^3🔬 EPA CTX
    Boiling Point 285.5 °C🔬 EPA CTX
    Melting Point 18.861 °C📊 OPERA
    Flash Point 117.28 °C📊 OPERA
    Refractive Index 1.482 Dimensionless📊 OPERA
    Molar Volume 165.667 cm^3/mol📊 OPERA

    Partition & Solubility

    LogP (Octanol-Water) 3.023 Log10 unitless📊 OPERA
    LogD (pH 5.5) 3.023 Log10 unitless📊 OPERA
    LogD (pH 7.4) 3.023 Log10 unitless📊 OPERA
    LogKoa (Octanol-Air) 6.08 Log10 unitless📊 OPERA
    Water Solubility 0.018 mol/L📊 OPERA
    Henry's Law Constant 0 atm-m3/mole📊 OPERA

    Transport Properties

    Vapor Pressure 0.006 mmHg📊 OPERA
    Viscosity 2.703 cP📊 OPERA
    Surface Tension 33.3 dyn/cm📊 OPERA

    Molecular Descriptors

    Topological Polar Surface Area 30.21 Ų💻 Computed
    H-Bond Donors 0 count💻 Computed
    H-Bond Acceptors 2 count💻 Computed
    Rotatable Bonds 4 count💻 Computed
    Aromatic Rings 1 count💻 Computed
    Molar Refractivity 47.223 cm^3/mol📊 OPERA
    Polarizability 18.721 Å^3📊 OPERA

    Data Sources:

    🔬 EPA Experimental data from U.S. EPA CompTox Chemicals Dashboard & CTX APIs. 📊 OPERA Predicted using EPA's OPERA QSAR models. 💻 Computed Calculated from SMILES using RDKit.

    Similar Posts